鼻腔NK/T细胞淋巴瘤的CT和MRI影像学表现

目的:探讨鼻腔NK/T细胞淋巴瘤的CT和MRI影像学特征,提高诊断水平.方法:搜集经手术病理证实的鼻腔NK/T细胞淋巴瘤19例,全部病例均有CT和/或MRI资料.结果:病变位于鼻腔左侧7例,右侧11例,双侧同时侵犯1例;局限于鼻前庭或鼻前部3例,鼻腔前中部6例,中后部2例,整个鼻腔受侵8例;肿瘤向鼻前庭生长并浸润鼻翼、鼻背及邻近面颊部皮肤11例;延伸至口咽部1例,侵犯眼眶2例,伴骨质破坏9例.CT显示肿瘤呈软组织密度充填鼻腔并沿鼻黏膜蔓延,MRI显示肿瘤T1WI呈等或稍低信号,T2WI呈不均匀稍高信号,增强后呈轻到中度不均匀强化.结论:鼻腔NK/T细胞淋巴瘤的影像学表现有一定特征性,CT扫描可清晰显示骨质破坏情况,MRI能够更清晰、准确显示病变侵犯范围.确诊须依赖病理学和免疫组化检查.     

鼻腔NK/T细胞淋巴瘤的影像学诊断

目的探讨鼻腔NK/T细胞淋巴瘤的CT及MRI表现特征。材料和方法回顾性分析21例经病理证实的鼻腔NK/T细胞淋巴瘤患者的CT和MRI影像学资料及临床资料。结果本组21例中单侧7例,双侧14例,依据病变范围将本病分为局限型和弥漫型两种类型。局限型13例,主要位于鼻腔内,其中鼻腔前部11例,鼻腔后部2例;骨质改变不明显,浸润鼻旁或面部皮下组织9例,弥漫型8例,肿瘤范围广泛并向鼻腔周围结构浸润扩展,其中累及鼻旁窦7例,侵入眼眶1例、颞下窝2例,延伸至鼻咽、口咽部并累及咽旁间隙6例,骨质破坏7例,颈部淋巴结受累1例。CT显示肿瘤呈软组织密度充填鼻腔并沿鼻黏膜蔓延,增强后轻到中度不均匀强化。MRIT1WI肿瘤呈等信号,信号强度类似或稍低于肌肉;T2WI呈不均匀稍高信号,信号强度高于肌肉,但低于鼻黏膜,增强后轻到中度不均匀强化。结论鼻腔NK/T细胞型淋巴瘤影像学表现有一定特征,CT、MRI检查可提示诊断,有利于确定病变范围及临床分期。     

原发鼻腔NK/T细胞淋巴瘤CT诊断

目的:探讨原发鼻腔NK/T细胞淋巴瘤的CT表现特点,提高诊断水平。方法:搜集8例经病理证实的原发鼻腔NK/T细胞淋巴瘤,术前均行CT检查,分析其CT表现。结果:8例中双侧2例,单侧6例;3例肿块弥漫生长呈"铸型"改变,5例呈局限性肿块,其中3例位于鼻腔前庭部,2例位于后鼻孔;4例病变累及鼻翼、鼻背部及面颊部,2例肿块累及上颌窦,5例出现副鼻窦炎,2例有骨质破坏;1例出现颈部及颌下淋巴结肿大;CT平扫肿块呈较均匀的软组织密度,增强呈轻到中度强化。结论:原发鼻腔NK/T细胞淋巴瘤好发于一侧或双侧鼻腔前下部,呈局限性或弥漫性软组织肿块,往往累及鼻背、鼻翼及颌面部软组织,常伴有中线结构的骨质破坏,CT表现有一定的特征性,有助于病变的诊断。     

鼻腔原发淋巴瘤的CT诊断

目的:总结鼻腔原发淋巴瘤的CT表现特点,探讨鼻腔淋巴瘤相对特异的CT征象,提高诊断水平。方法:回顾性分析16例病理证实的鼻腔淋巴瘤的临床、病理及CT资料。结果:16例鼻腔淋巴瘤病理上均为非何杰金淋巴瘤(NHL),其中15例为NK/T细胞淋巴瘤,1例为弥漫性大B细胞淋巴瘤。CT表现:(1)发病部位:均为单侧发病,15例发生于鼻腔前部外侧壁,主要累及中下鼻甲,肿块多沿鼻甲形状蔓延生长,1例肿瘤主要位于鼻后孔;(2)密度:14例密度均匀,2例密度不均。增强扫描轻中度强化;(3)临近结构改变:①鼻前庭皮肤受累10例;②骨质破坏:15例NK/T细胞淋巴瘤未见明显骨质破坏,1例弥漫性大B细胞淋巴瘤中鼻甲及钩突骨质部分吸收;③鼻窦受累:9例表现为鼻窦粘膜增厚或鼻窦内软组织肿块影;④1例侵犯眶内。结论:CT发现单侧鼻腔前部肿物,主要位于中下鼻甲,密度均匀,增强扫描轻~中度强化;骨结构破坏不明显;鼻前庭皮肤受侵;应考虑鼻腔原发淋巴瘤的可能。CT能直接全面地显示病变的侵犯范围及程度,为临床治疗提供依据。     

鼻NK/T细胞淋巴瘤同鼻息肉、内翻乳头状瘤的CT对比分析

目的 分析鼻NK/T细胞淋巴瘤的CT表现.方法 回顾性分析11例鼻NK/T细胞淋巴瘤、134例鼻息肉、24例鼻内翻乳头状瘤的CT征象,将相应征象在3类疾病中出现的差异用Fisher精确检验比较.结果 较鼻息肉,鼻NK/T细胞淋巴瘤多单侧鼻腔发病,表现为结节肿块或铸型生长,易侵犯鼻前庭、鼻翼及鼻背部皮肤、鼻咽侧壁、鼻中隔或鼻底部黏膜、周围骨质破坏;较鼻内翻乳头状瘤,鼻NK/T细胞淋巴瘤病变易侵犯鼻前庭、鼻翼及鼻背部皮肤、后鼻孔及鼻咽腔、鼻中隔或鼻底部黏膜.结论 鼻NK/T细胞淋巴瘤多发生于单侧鼻腔,密度均匀,沿侧壁匍匐生长,易侵及鼻黏膜及前后组织结构,早期骨质破坏轻微.     

鼻腔NK/T细胞淋巴瘤的CT诊断

目的探讨鼻腔NK/T细胞淋巴瘤的表现特征。方法回顾性分析26例经病理证实的鼻腔NK/T细胞淋巴瘤患者的CT表现,评价其诊断意义。结果 CT表现:①21例发生于鼻腔前部;②15例出现鼻背部及面颊部软组织肿胀,皮下脂肪消失;③8例出现骨质破坏,其中7例破坏较轻微;④6例出现咽淋巴环增厚;⑤5例增强扫描表现为轻度强化。结论鼻腔NK/T细胞淋巴瘤具有相对特异性的CT表现,咽淋巴环增厚具有一定诊断价值,CT检查对本病诊断具有重要意义。     

鼻腔T/NK细胞型淋巴瘤的影像学诊断

目的探讨鼻腔T/NK细胞型淋巴瘤的CT和MRI特点。方法回顾性分析35例经组织学证实鼻腔T/NK细胞型淋巴瘤的影像学资料。结果根据病变的范围分为局限型和弥漫型2种类型。CT表现:局限型25例,位于鼻腔前部23例,后部2例,向前浸润鼻前庭、鼻翼、鼻背及邻近面颊部皮肤23例;病灶密度均匀8例,不均匀17例,增强后低度强化6例,中度强化3例;中下鼻甲、鼻中隔轻微浸润性破坏2例。弥漫型10例,表现为鼻腔中线区骨质破坏伴软组织肿块,9例侵犯邻近鼻窦及面颊部软组织,6例蔓延到眼眶、颞下窝、翼腭窝,4例浸润颅底骨髓,3例破坏硬腭。MRI表现:T1WI低信号5例(与肌肉比较,以下同),等信号3例;T2WI高信号6例,等信号2例;病变低度强化2例,中度强化4例。3例沿翼腭窝神经周围蔓延。结论大多数鼻腔T/NK细胞型淋巴瘤有特征影像学征象,可提示诊断。     

口咽部非霍奇金淋巴瘤的CT诊断

目的 分析口咽部非霍奇金淋巴瘤(non-Hodgkin's lymphoma,NHL)的CT表现特征,探讨各种不同病理类型NHL的CT表现特点. 资料与方法 回顾性分析33例经病理证实的口咽部NHL患者的CT表现. 结果 33例中,B细胞来源18例(54.5%),T和NK细胞来源15例(45.5%).病变分布:扁桃体14例(弥漫性大B细胞淋巴瘤8例、NK/T细胞淋巴瘤5例、套细胞淋巴瘤1例);舌根10例(弥漫大B细胞淋巴瘤5例、滤泡性淋巴瘤3例、血管免疫母细胞性T细胞淋巴瘤1例、周围T细胞淋巴瘤1例);软腭2例(NK/T细胞淋巴瘤1例,结外边缘区B细胞淋巴瘤1例);累及两个以上口咽部位7例,均为NK/T细胞淋巴瘤.33例中,肿块型18例,其中13例为弥漫大B细胞淋巴瘤;弥漫型10例,其中8例为NK/T细胞淋巴瘤;无明显异常CT表现者5例. 结论 口咽NHL多发生于腭扁桃体及舌根,病理类型以弥漫大B细胞淋巴瘤和NK/T细胞淋巴瘤为主;CT对于NHL的鉴别诊断和病变范围的判断有重要价值.     

PET-CT、CT及MRI诊断原发性鼻腔恶性淋巴瘤的临床价值分析

目的探讨原发性鼻腔恶性淋巴瘤PET-CT、CT及MRI诊断价值。方法回顾性分析32例原发性鼻腔恶性淋巴瘤患者PET-CT、CT及MRI影像学表现,并与手术及病理结果进行比较。结果 1)32例患者后均经病理证实为非霍奇金淋巴瘤,其中明确诊断为NK/T细胞淋巴瘤27例;2)PET-CT的符合率为93.7%,显著高于单独应用CT、MRI符合率的71.9%、75.1%,差异均有统计学意义(X~2=7.2346,P=0.0032;X~2=6.9538,P=0.0037)。结论原发性鼻腔恶性淋巴瘤的PET-CT表现有一定的特征性,结合其影像表现及病理检查,可提高该病诊断的敏感性和准确性,并显示鼻腔恶性淋巴瘤侵犯范围及程度。     

上呼吸道淋巴瘤的MRI征象初探

目的 探讨上呼吸道淋巴瘤(upper respiratory tract lymphoma,URTL) MRI特点.方法 选取URTL 19例,其中10例NK/T细胞淋巴瘤(NK/T cell lymphoma,NK/TCL)和9例B细胞性淋巴瘤(B cell lymphoma,BCL).18例行MRI平扫+增强,1例...     

Primary nasal lymphoma, NK/T-cell type: report of two cases with similar presentation but different outcome

Two cases of natural killer (NK)/T-cell primary nasal lymphoma with similar clinical presentations are reported, for comparison and contrast, to highlight the clinical issues and challenges posed by this unusual disease, its aggressiveness being matched only by its rarity. Presenting as a lesion in the nasal cavity with histological features of malignant lymphoma, primary nasal lymphoma is an uncommon extranodal lymphoma, which poses problems in both diagnosis and management. In people of oriental descent, the common cell subtype is NK/T-cell. Although it is generally thought that combination treatment with chemotherapy and radiation is the best management for early stage non-Hodgkin's lymphoma (NHL), there is still debate as to whether combined therapy is optimal treatment for this particular subtype of NHL, given that it responds less well to conventional chemotherapy. Herein we report two patients to illustrate these controversies.     

Primary peripheral T-cell lymphoma of the face other than mycosis fungoides. Computed tomography and magnetic resonance findings

OBJECTIVE: To describe the radiologic findings of primary peripheral T-cell lymphoma (PTCL) of the face other than mycosis fungoides. METHODS: Computed tomography (CT) and magnetic resonance imaging (MRI) findings of 5 consecutive patients with pathologically proven primary facial PTCL other than mycosis fungoides were retrospectively evaluated. Patients with PTCL involving the sinonasal cavity or lymph nodes were excluded. RESULTS: Diagnoses of patients included in this study consisted of natural killer/T-cell lymphoma (n = 2), subcutaneous panniculitis-like T-cell lymphoma (n = 1), anaplastic large cell lymphoma (n = 1), and PTCL not otherwise specified (n = 1). Infiltration or swelling of the superficial space of the face was noted on both CT and MRI, mimicking inflammation or infection. Also seen were well-enhancing small nodular (n = 2) or infiltrative mass-like lesions (n = 2) within the areas of infiltration, which showed intermediate signal intensity on T2-weighted images. One patient demonstrated infiltration and swelling alone. CONCLUSIONS: Primary facial PTCL is a rarely encountered tumor and demonstrates infiltration or swelling mimicking inflammation or infection. Nodular or infiltrative mass-like lesions may be helpful for its diagnosis.     

^18F-FDG PET／CT在自然杀伤／T细胞淋巴瘤显像诊断及分期中的应用

目的探讨^18F-脱氧葡萄糖（FDG）PET／CT在自然杀伤（NK）／T细胞淋巴瘤的病灶检测及分期中的价值。方法13例初诊和2例复发NK／T细胞淋巴瘤患者行全身^18F-FDGPET／CT显像。病灶处出现^18F-FDG异常浓聚为阳性。^18F-FDG摄取采用最大标准摄取值（SUVmax）进行定量。所有受检者随访时间均〉6个月。统计学比较用t检验。结果（1）15例NK／T细胞淋巴瘤患者^18F-FDG PET／CT显像均为阳性。11例鼻型患者中,10例PET／CT于鼻腔或鼻咽部探测到肿瘤病灶,且6例突出鼻腔外侵及鼻旁周围组织,7例PET／CT显像于鼻腔外发现1处或多处淋巴瘤受侵病灶。4例非鼻型患者,PET／CT于鼻腔外发现多部位肿瘤侵犯。鼻内、鼻外病灶的SUVmax分别为12．42±9．25和9．54±7．12,两者差异无统计学意义（t=1．120,P〉0．05）。（2）15例中有2例显像前不明原因发热者在PET／CT引导下行病理检查,明确诊断。13例诊断已明确者,7例PET／CT发现更多淋巴瘤病灶,6例因PET／CT检查改变分期。Ⅰ～Ⅱ期患者的SUVmax;稍低于Ⅲ～Ⅳ期者,分别为8．44±5．56和10．32±7．80,但差异无统计学意义（t=0．757,P〉0．05）。结论NK／T细胞淋巴瘤病灶呈^18F-FDG高摄取;在其病灶检测和分期方面,PET／CT显像有优势。     

MR imaging of nasal T-cell/natural killer cell lymphoma

OBJECTIVE: Nasal T-cell/natural killer cell lymphoma is a distinct clinicopathologic entity derived from natural killer cells. The purpose of the study was to describe the MR features of this rare nasal cavity tumor and correlate MR findings with stage of disease. CONCLUSION: Nasal T-cell/natural killer cell lymphoma frequently exhibits diffuse invasion of the nasal cavity with necrosis, midline destruction, and extension into the nasopharynx. These features may be seen in both early- and late-stage disease.     

鼻腔原发性恶性黑色素瘤的影像学表现及鉴别诊断

目的:探讨鼻腔原发性恶性黑色素瘤的影像学表现及鉴别诊断.方法:回顾性分析经病理证实的9例鼻腔原发性恶性黑色素瘤的影像学表现.结果:9例患者主要CT表现为单侧(8例)或双侧(1例)鼻腔内密度均匀、形态不规则的软组织肿块,无钙化,8例(8/9)伴邻近结构的侵犯,2例增强后肿瘤不均匀明显强化,MRI表现:1例表现为典型的T1...     

鼻腔淋巴瘤的CT诊断

目的：探讨原发鼻腔淋巴瘤的CT诊断。材料和方法：回顾性分析34例鼻腔淋巴瘤的CT表现,对肿瘤范围、密度、形态边缘和骨质情况进行分析。结果：肿瘤侵犯外鼻及鼻旁皮下20例、上颌窦17例、筛窦16例、鼻咽12例、眼眶10例、蝶窦7例、额窦4例、对侧鼻腔5例,个别病例侵犯颞下窝、颅前窝、颞窝、上腭和眶下裂。肿瘤分期：一期6例,二期10例,三期16例,四期2例。大多数病例病灶呈弥漫浸润状,边缘不清楚,密度均匀23例,稍不均匀11例,多数呈轻度强化。22例伴有骨质吸收破坏,12例无骨质异常。结论：鼻腔T细胞型淋巴瘤的CT表现具有一定特征,CT对其诊断具有较大的价值。