可弯曲内科胸腔镜对不明原因胸腔积液的诊断价值

目的 评价可弯曲内科胸腔镜对不明原因胸腔积液的诊断价值。方法 回顾性分析我科2006年1月至2008年9月51例不明原因胸腔积液患者的胸腔镜检查。结果 26例患者确诊为结核性胸膜炎,16例为恶性肿瘤胸膜转移,恶性胸膜间皮瘤及化脓性胸膜炎各1例, 2例病理结果阴性、经临床随访排除其他疾病确诊为全身性疾病引起的漏出液,5例未明确诊断,总的确诊率为86.3%。结论 可弯曲内科胸腔镜对不明原因胸腔积液的诊断具有较高的诊断价值,可作为不明原因胸腔积液患者的常规检查方法。     

72例不明原因胸腔积液的内科胸腔镜诊治分析

目的：探索不明原因腔积液的病因及可弯曲内科胸腔镜的诊断及治疗价值。方法选取该院2013年1月-2015年12月收治的胸腔积液原因待查的患者72例为研究对象,采用可弯曲内科胸腔镜对72例不明原因胸腔积液患者进行胸腔镜检查术,观察镜下表现、直视下取病理检查,分析病因并观察手术的安全性。结果72例不明原因胸腔积液中确诊66例,确诊率达91.7%,包括胸膜转移癌34例,结核性胸膜炎30例,诊断为胸膜转移瘤的年龄显著高于结核性胸膜炎患者;积液表现为黄色和血性2种,黄色胸腔积液患者以良性病变为主,血性胸腔积液均为恶性病变;镜下表现为粟粒样结节的结核性胸膜炎特异性最高,恶性病变镜下主要表现为单发、多发肿块及大小不等的结节,其他胸膜充血、糜烂、粘连主要为结核及非特异性炎性改变;胸腔镜下分离粘连带,可显著增加患者的肺活量、肺总量;所有患者未见严重并发症。结论不明原因胸腔积液病因以胸膜转移瘤及结核性胸膜炎为主,患者的年龄、胸水的颜色、镜下表现对诊断具有指导意义,通过镜下粘连带分离可以改善患者肺功能,内科胸腔镜检查术是一种安全、高效的诊治技术,可做为不明原因胸腔积液的常规诊断方法。     

内科胸腔镜在不明原因胸腔积液诊断中的应用

目的 初步探讨可弯曲式内科胸腔镜在不明病因胸腔积液诊断中的应用价值.方法 应用内科胸腔镜对26例通过胸腔积液常规、生化、微生物及细胞学等实验室方法仍不能明确病因的胸腔积液患者进行检查.结果 结核性胸膜炎8例(30.8%),肺癌胸膜转移11例,乳腺癌胸膜转移2例,恶性胸膜间皮瘤2例.3例(11.5%)病理为阴性结果,恶性...     

内科胸腔镜在疑难性胸腔积液诊断中的应用

目的:探讨内科胸腔镜对疑难性胸膜疾病的诊断价值.方法:回顾性分析36例原因不明的胸腔积液患者内科胸腔镜检查诊断结果及并发症.结果:36例不明原因的胸膜疾病患者,通过内科胸腔镜检查,确诊了35例,阳性率达97.2%.结论:内科胸腔镜检查对不明原因的胸腔积液的病因诊断是一种易操作、较安全的诊断方法,其阳性率高,无严重并发症.     

内科电子胸腔镜早期诊断不明原因胸腔积液40例

目的对不明原因胸腔积液患者40例行内科胸腔镜检查,早期取得病理结果,探讨其临床价值。方法新乡市中心医院于2010年2月至2011年3月采用日本OlympusLTF240型电子内科胸腔镜对不明原因胸腔积液患者40例行内科胸腔镜检查。术后行胸片了解置管位置及胸腔变化,术中密切观察神志及血压、呼吸、心率、心律及血氧饱和度变化。结果胸腔积液患者经胸腔镜检查及活检病理明确诊断：肺癌胸膜转移28例（70％）,结核性肉芽肿12例（30％）。手术并发症少。胸水癌胚抗原高于正常的患者,胸腔镜应全面仔细寻找恶性根据。结核性胸腔积液患者做胸腔镜时均可找到结核结节病灶,病理明确诊断。对结核变态反应可引起胸腔积液的机制不太支持。结论内科胸腔镜作为一项呼吸内科医生可操作的安全、有效的微创诊疗技术,对不明原因胸腔积液患者的早期诊断和治疗具有重要的临床应用价值。     

尖端可弯曲内科胸腔镜在不明原因胸腔积液中的诊断价值

目的 了解尖端可弯曲内科胸腔镜在不明原因的胸腔积液诊断中的应用价值.方法 选取2007年10月-2008年12月在上海交通大学附属胸科医院呼吸内科住院的60例胸腔积液患者,男35例,女25例.所有患者通过胸腔积液常规、生化、微生物学及细胞学等实验室检查均未能明确病因,而行尖端可弯曲的内科胸腔镜检查.结果 60例胸膜疾病患者中,结核29例(48.3%),恶性肿瘤18例(30.0%),慢性炎症6例(10.0%),乳糜胸1例(1.7%),胸腔内异位肝1例(1.7%),胸膜结缔组织病变1例(1.7%),诊断阳性率为93.3%(56/60).术后发生疼痛及发热各1例,未发生其他严重不良事件.结论 尖端可弯曲的内科胸腔镜是一项简单、安全、有效的检查方法,可帮助我们进一步明确不明原因的胸腔积液的病因.     

可弯曲式内科胸腔镜对不明原因胸腔积液的诊断价值

目的探讨可弯曲式内科胸腔镜在不明原因胸腔积液诊断中的应用价值。方法2009年4月～2010年5月,应用可弯曲式内科胸腔镜对我院呼吸科病房中63例通过胸腔积液常规、生化、微生物学及细胞学等实验室检查或通过诊断性抗结核治疗仍不能明确积液原因的患者进行内科胸腔镜检查,其中男38例,女25例。结果63例不明原因的胸腔积液患者中恶性肿瘤21例（33．33％）,结核28例（44．45％）,脓胸6例（9．52％）,肺炎合并胸膜炎4例（6．35％）,心力衰竭合并胸膜漏出液4例（6．35％）。结论可弯曲式电子内科胸腔镜是一种简单、安全、有效的检查工具,可帮助我们进一步明确胸腔积液的病因,尤其是对于不明原因的胸腔积液的病因学诊断具有极大意义。     

胸腔镜在胸腔积液诊断及治疗中的作用

目的 分析内科胸腔镜在不明原因胸腔积液诊断及治疗中的作用.方法 收集2015年5月—2016年5月我院收治的不明原因胸腔积液患者54例作为研究对象,使用内科胸腔镜进行临床诊断与治疗.结果 54例患者中51例经过内科胸腔镜检查与病理活检得到明确诊断,确诊率为94.44%;另外3例胸膜粘连严重无法进行检查与诊断.51例使用滑石粉喷洒胸膜固定术,成功率为84.31%(43/51),均无严重并发症发生.结论 内科胸腔镜诊断和治疗胸腔积液,对患者创伤小、诊断率高,术后并发症少,在诊断以及治疗恶性胸腔积液中有明显优势,具有良好的临床应用价值.     

内科胸腔镜检查单侧不明原因胸腔积液11例并文献复习

目的 探讨内科胸腔镜在单侧不明原因胸腔积液中的诊断价值及安全性评估.方法 对11例通过无创检查手段仍不能明确病因的单侧胸腔积液患者行局麻下内科胸腔镜检查,并对胸膜上病灶钳夹行病理活检.结果 所有检查患者镜下均发现所在胸膜腔内胸膜上有数量、大小、颜色不等的结节样病变,其中9例经病理证实为结核性胸膜炎,1例病理证实为胸膜间皮瘤,1例回报少量间皮细胞及成纤维细胞.结论 内科胸腔镜检查对于单侧不明原因胸腔积液是一项简单、安全、高效的检查方法,适合有相应条件的基层医院推广.     

内科胸腔镜检查在胸腔积液诊断中的应用

目的：探讨内科胸腔镜检查在不明原因胸腔积液诊断中的价值。方法：55例胸腔积液患者行内科胸腔镜检术,直视下取病变组织行病理检查。结果：胸腔镜下可见胸膜多发乳白色结节31例,胸膜增厚纤维分隔形成7例,充血水肿6例,弥漫性粟粒样乳白色结节4例,多发结节伴胸膜黏连4例,胸膜白斑2例,无异常发现1例。病理诊断示胸膜结核28例,胸膜转移癌17例,慢性非特异性炎症7例,胸膜间皮瘤1例,胸膜转移癌伴结核性胸膜炎1例,正常胸膜组织1例。55例不明原因胸腔积液患者,经胸腔镜检查,确诊47例。所有病例无严重并发症。结论：内科胸腔镜检查对胸腔积液是一种安全、有效、诊断率高的检查方法。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.