血脂康与脂必妥降脂疗效比较

目的比较血脂康与脂必妥降脂疗效.方法随机将门诊60例按标准诊断的高脂血症患者分为血脂康组(治疗组)和脂必妥组(对照组)各30例.治疗组采用血脂康10 mg,3次/d;对照组采用脂必妥0.5 g,3次/d.两组疗程时间均8 wk.分别在服药前、服药4 wk、8 wk空腹抽血测定TC、TG、HDL-ch、测算TC-HDL、ch/HDL、ch比值.结果两组治疗后8 wk均有效;而两组间总有效率治疗组比对照组TC、TG、HDL-ch、TC-HDL-ch/HDL-ch分别高20.00%、10.00%、3334%、10.00%;TC降低、HDC-ch升高、TC-HDL-ch/HDL-ch比值均非常明显(P＜0.01),TG降低显著(P＜0.05).两组治疗前4 wk,TC、TG降低,HDL-ch升高,TC-HDL-ch/HDL-ch比值,治疗组在治疗4 wk后均有效(P＜0.05),而对照组仅TC降低(P＜0.05);8 wk后两组均有效,但治疗组在两组对比有效的基础上,TC降低非常显著(P＜0.01),TG降低、HDL-ch升高,TC-HDL-ch/HD-ch比值升高,均有显著改变(P＜0.05).结论血脂康降低血脂谱各项指标,升高HDL-ch比脂必妥效果好,且疗效十分可靠.     

血脂康和脂必妥治疗中老年高脂血症的比较

观察比较血脂康和脂必妥治疗中老年高脂血症病人的调脂作用，62例高脂血症病人随机分成2组，血脂康组30例，脂必妥组32例，疗程均为8周。结果两组对HDL－C上升差别有高度显著性(P＜0.01)，TG、LDL－C、（TC－HDL－c）／HDL－c下降差别有显著及高度显著性（P＜0．05及0．01），此外对TC也有不同程度的作用，未见严重副作用，表明两药皆为安全有效的调脂药物。     

血脂康与脂必妥对高胆固醇血症的调脂作用比较

目的比较两种国产中药血脂康和脂必妥的调脂作用.方法 60例高脂血症患者(实际完成57例)随机分成两组,服药前及服药后4,8周分别测血脂.结果①两种药物在4周时TC分别下降19%(P＜0.001)和11%(P＜0.05),TG分别下降21%,23%(P均＜0.01);LDL-C分别下降27%(P＜0.05),14%(P＞0.05);脂必妥在8周时LDL-C下降22%(P＜0.05) ;HDL-C 4,8周分别上升15%(P＜0.01),7%(P＞0.05).②ApoB100分别降低12%和10%(P＜0.01),而ApoAⅠ升高不明显,分别为9%和7%(P＞0.05). ③除LDL-C外,其余两者4,8周的下降幅度均无统计学意义.结论二药均有较好的调脂效果,血脂康略优于脂必妥.     

血脂康和脂必妥治疗中老年高脂血症的比较

观察比较血脂康和脂必妥治疗中老年高脂血症病人的调脂作用６２例高脂血症病人随机分成２组，血脂康组３０例，脂必妥组３２例，疗程均为８周，结果两缚对ＨＤＬ－Ｃ上升差别有高度显著性（Ｐ〈０．０１），ＴＧ，ＬＤＬ－ｃ（ＴＣ－ＨＤＬ－ｃ）／ＨＤＬ－ｃ下降差别有显著及高度显著性（Ｐ〈０．０５及０．０１）此外对ＴＣ也有不同程度的作用，未见严重副作用，表明两药皆为安全有效的调脂药物。     

脂必妥与烟酸肌醇酯治疗高脂血症的比较

高脂血症是临床上常见的中老年疾病 ,是引起动脉粥样硬化的一个主要因素 ,降低血脂水平是防治心血管疾病的重要手段之一。我们使用脂必妥与烟酸肌醇酯治疗原发性高脂血症 4 6例 ,其中用脂必妥治疗高脂血症 2 6例 ,获得满意效果 ,现报告如下。1　资料与方法1.1　病例选择　根据卫生部心血管系统药物临床研究指导原则、诊断标准 ,选择高脂血症病人 4 6例 ,随机分为两组 ,两组年龄均为 5 4± 9岁 ,其中脂必妥组 2 6人 ,男性 17例 ,女姓 9例 ,合并高血压 10例 ,冠心病 8例 ,烟酸肌醇脂组 2 0例 ,男姓 13例 ,女姓 7例 ,合并高血压 8例 ,冠心病 5…     

苯那普利与卡维地洛治疗原发性高血压的比较

目的比较苯那普利与卡维地洛治疗高血压的疗效和安全性。方法将129例原发性高血压患者随机分为苯那普利组65例(男42例,女23例,年龄55±9岁),用苯那普利5 mg～10mg,po,qd:卡维地洛组64例(男41例,女23例,年龄54±10岁),以卡维地洛10 mg～20 mg,po,Bid,2组疗程均为4wk。结果治疗4wk 后,两组血压下降差别均有非常显著意义(P<0.01);苯那普利组的总有效率为91%,卡维地洛组为92%,两组疗效差别无显著意义(P>0.05)。苯那普利与卡维地洛均无严重不良反应。结论苯那普利与卡维地洛治疗原发性高血压疗效均好,较安     

京必舒新与舒降之治疗高脂血症及对血液流变学影响的比较

目的　比较国产辛伐他汀 (京必舒新 )与合资辛伐他汀 (舒降之 )治疗高脂血症及对血液流变学的影响及不良反应。方法　 39例高脂血症患者 (男性 2 1例 ,女性 1 8例 ,年龄 56土 1 0a) ,用京必舒新 2 0mg,p .o ,qd ,× 4wk ,另38例高脂血症患者 (男性 2 2例 ,女性 1 6例 ,年龄 55 +9a)用舒降之 2 0mg ,p .o,qd× 4wk ,结果　京必舒新降低TC ,TG ,LDL -C为 2 8.1 % ,1 7.2 % ,2 6 .7%及升高HDL -C2 0 % ;舒降之降低TC ,TG ,LDL -C为 2 9.8% ,2 3 .3 % ,32 .3 %及升高 2 6 .7% ,2组组间比较 ,差别无显著意义 (P >0 .0 5) ,2组对血液流变学各项指标影响比较 ,差别亦无显著意义 (P >0 .0 5)。结论　国产辛伐他汀 (京必舒新 )与合资辛伐他汀 (舒降之 )均为有效的调脂药物 ,疗效相同 ,对血液流变学的影响相同。     

脂必妥与多烯康治疗高脂血症的比较

<正> 高脂血症是发生冠心病的主要因素之一,治疗高脂血症对防治冠心病很重要。脂必妥是降血脂新药,主要成份为红曲,富含HMG—COA还原酶抑制剂,能降低胆固醇(TC)和低密度脂蛋白(LDL—ch),升高高密度脂蛋白(HDL—ch),以达到降脂作用。多烯康含有二十碳五烯酸和二十二碳六烯酸,它们降低三酰甘油(TG,昔名甘油三脂),并抑制血小板的聚集,保护血管内皮细胞,预防动脉粥样硬化的发生。现将近年脂必妥与多烯康对比治疗高脂血症47例的情况报告如下。1.资料与方法1·1 一般资料 高脂血症病人,其血清胆固醇TC≥5.8mmol/L,TG≥1.58mmol/L,HDL—ch男≤1.04mmol/L,女性≤1.17mmol/L,具备2项以上者入选。高脂血症47例随机分2组。脂必妥组24例(男性     

脂必妥治疗冠心病合并高脂血症临床观察

目的 探讨脂必妥治疗冠心病合并高脂血症患者的临床疗效.方法 选择冠心病合并高脂血症患者68例,随机分为对照组和治疗组,对照组应用常规治疗(极化液、消心痛等).治疗组在常规治疗基础上,加用脂必妥(成都地奥制药厂生产)每次3片(0.35g/片),每天2次饭后口服,连续用药观察4周.结果 治疗组显效18例,有效12例,无效3例,加重1例,总有效率88.1%.对照组显效10例,有效13例,无效8例,加重3例,总有效率67.1%.可见治疗组优于对照组.结论 脂必妥调脂疗效确切,无明显不良反应,对血糖、肝肾功能无影响,用药安全,耐受性良好,是可供临床选用的治疗高脂血症合并冠心病的理想药物.     

两种他汀类药物降血脂作用的临床比较

目的比较地奥脂必妥和洛伐他汀降低血脂的疗效和不良反应。方法152例高脂血症患者随机分成治疗组和对照组各76例,治疗组口服地奥脂必妥0.1g,2次/d;对照组口服洛伐他汀20mg,1次/d;疗程均为12周。结果治疗组和对照组降低血脂疗效相当(P>0.05),但治疗组不良反应发生率为7.8%,对照组不良反应发生率为53.9%,两组比较差异有显著性(P<0.05)。结论地奥脂必妥降脂疗效和洛伐他汀相当,但不良反应发生率低,是一种安全、有效的天然他汀类降脂药物。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.