A Study of Hemorrheologic Changes in Patients with Severe Viral Hepatitis

The study of the micro and macro-hemorrheologic changes and theflow conditions of the nail-fold microcirculation in 30 patients with severe viralhepatitis was reported.Normal individuals,and patients with acute icterichepatitis or chronic active hepatitis were employed as the controls.The changes observed in the patients with severe viral hepatitis were asfollows:The reduced viscosity of the whole blood and the plasma viscosityincreased markedly;the dispersion rate of the values of blood viscosity increasedas the clinical state of the patient became worse;and the factors increasing theblood viscosity(i.e.increase of the immuno-globulin level,prolongation of theerythrocyte electrophoretic mobility time,and increase of RBC sedimentation rate)and those decreasing the blood viscosity(i.e.decrease of hematocrit reading,fibrinogen level and platelet aggregation ratio)existed simultaneously in thepatient.The changes of the flow conditions of the nail-fold microcirculation werein close correlation with the increase of blood viscosity and the severity of thedisease.The etiology and mechanism of the above mentioned changes were discussed     

中西医结合治疗慢性乙型重型肝炎122例观察

本文总结了中西医结合治疗122例慢性乙型重型肝炎(早、中、晚期)的经验。全部病例均用基础疗法,部分病例加用肝细胞生长因子(HGF)。中药治疗分为凉血活血解毒扶正组(凉解组)及清热解毒组(清解组)。结果总有效52例,无效70例。血清胆红素、凝血酶原活动度值及就诊时间对预后有重要影响。凉解组与清解组总的病死率及两组病例早期加与不加HGF的病死率均无差异。中期凉解组加与未加HGF的存活率有显著性差异,P<0.01;清解组加与未加HGF生存率无显著性差异,P>0.05:但中期病例凉解组与清解组加HGF的生存率有显著性差异,P<0.01。     

肝细胞治疗肝衰竭的机理及临床意义

近十余年来许多学者致力于肝细胞治疗实验性肝衰竭的研究,发现移植或输注肝细胞或再生肝胞质液(Cytosol)可显著提高肝衰动物的存活率。苏联和日本学者已将动物的肝细胞输入人体来代替失去功能的肝     

74例重症病毒性肝炎治疗分析

1980年1月至1982年12月3年间，我科共收治重症病毒性肝炎（下简称重肝）74例，就其治疗结果进行分析，探索影响治疗结果的因素，以指导今后重肝的治疗。     

30例重型病毒性肝炎的血液流变学观察

本实验对30例重肝病人血液宏观和微观流变学及甲皱襞微循环流态进行了观察,并设正常人、急黄肝和慢活肝病人为对照组。重肝病人的主要变化为:全血还原粘度和血浆粘度明显增高;血液粘度值离散度随病情加重而增大;增高和降低血液粘度的因素同时存在,即免疫球蛋白增高、红细胞电泳时间延长、血沉增速,同时红细胞压积、纤维蛋白元减少、血小板聚集功能降低;甲皱襞微循环流态和流速改变与病情和血液粘度增高程度有一定平行关系。文中对上述变化的原因和机理进行了讨论。     

重型及慢性病毒性肝炎患者血浆维生素E水平测定及其治疗作用

应用维生素Ｅ(ＶＥ)防治急性肝坏死及慢性肝损伤的实验研究国内外已有报道[1,2 ] ,但有关临床应用的研究较少。我们观察了我院部分重型肝炎 (ＳＨ )及慢性肝炎 (ＣＨ)患者血浆ＶＥ水平变化 ,并就二者辅助ＶＥ治疗的临床疗效作一总结。对象与方法1.对象 :为本院住院的部分ＳＨ (2 9例 )及ＣＨ (41例 )患者共 70例 ,男性 5 0例 ,女性 2 0例 ,年龄 19～ 71岁。诊断标准参照 1995年修订的病毒性肝炎防治方案 ,部分血清胆红素 >171μｍｏｌ/Ｌ ,但凝血酶原活动度高于 40 %而未达ＳＨ条件的病例(或经组织学检查确诊 )纳入ＣＨ。 70例中 5 7例有肝…     

应用大剂量维生素E治疗重型肝炎临床初步探讨

１　材料和方法１．１　材料　为本院住院的２９例慢性重型肝炎（ＳＨ）患者,随机分组,维生素Ｅ（ＶＥ）治疗组１２例（男９例,女３例,平均年龄４４－６岁）,对照组１７例（男１３例,女４例,平均年龄３９－９岁）．其中单纯乙型肝炎感染标志阳性者２０例,甲、乙型肝炎感染标志阳性１例,乙、丁型肝炎感染标志阳性两组各４例．诊断符合１９９５年（北京）全国传染病寄生虫病会议修订标准,两组各１０例经肝脏组织病理学检查证实．两组主要症状体征及生化指标大致相同（Ｐ＞０－０５）．献血员１１例作为健康对照．１．２　方法１．２…     

慢性肝炎151例临床与病理诊断对比分析

慢性病毒性肝炎临床表现轻重不一,单凭临床资料有时不易作出正确诊断,我们对1983年以来收治的151例慢性肝炎病人临床及病理资料进行对比分析,现报道如下。     

A Clinical Study of Plasma Fibronectin in Patients with Severe Viral Hepatitis

Plasma fibronectin was determined serially with both simpleradioimmunadiffasion and modified indirect hemoagglutination test(usinggelatin-coated sheep RBC)in 30 patients with severe viral hepatitis(SVH),100normal subjects and 30 cases of chronic active hepatitis(CAH)were also studiedto serve as controls.Liver function test,serum complement 3 and immunoglobulinwere determined simultaneously.Endotoxin was assayed with limulus lysate testin 21 cases of SVH and 14 cases of CAH.The normal value of plasma fibronectin was 284.31±45.56μg/ml and 1:30.64(geometrical mean).Plasma fibronectin level decreased significantly in SVHpatients.Obvious correlations were found between the levels of plasma fibronectinand the valuers of total serum bilirubin,prothrombin time,complement 3,immunoglobulin M,and blood platelet count.Low plasma fibronectin levels wereremarkably associated with the occurrence of endotoxemia.It is concluded that serial determination of plasma fibronectin can reflect theseverity of the illness and the prognosis of the patients with SVH.     

Platelet Aggregation in Patients with Severe Viral Hepatitis

Platelet aggregation ratio (PAR) was assessed in 45 patients with severe viralhepatitis (SVH) with Born's method.The PAR of normal individuals,patients with acuteicteric hepatitis,and those with chronic active hepatitis were also studied to serve ascontrols.It was found that PAR decreased markedly in SVH patients,which was marked in theearly stage of SVH,more marked in the intermediate stage,and most marked in the latestage.The changes of PAR were in negative correlation with those of serum total bilirubin,and in positive correlation with those of prothrombin activity.The reduction of PAR inSVH patients might be ascribed to the defect of platelets themselves as revealed bycross-over experiments.The results of this study indicate that PAR may be useful in judging the severity ofSVH patients since the degree of PAR reduction parallels closely with the severity of liverdamage.Finally,the condition of platelets in vivo and in vitro in SVH patients werediscussed.