Effects of Interferon on Mitomycin C-Induced Sister Chromatid Exchanges and on Ultraviolet Induced Unscheduled DNA Synthesis

This article is about the effects of interferon(IFN)on sisterchromatid exchange(SCE)frequencies induced by mitomycin C(MMC)and/or unscheduled DNA synthesis(UDS)induced by ultra-violet light(UV).The result shows that SCE frequencies in peri-pheral lymphocytes from 4 normal individuals and 3 patients withxeroderma pigmentosum(XP)treated with IFN before the additionof MMC were much lower than those of the controls.But after thetreatment of IFN followed by UV irradiation,no difference was fo-und between the UDS levels of the lymphocytes from 2 normal in-dividuals and 2 patients with XP and those from the controls.Thewriters deduce that IFN may have some effect of antimutation     

干扰素对丝裂霉素C诱发的姊妹染色单体互换和紫外线诱发的DNA修复合成影响的研究

本文报告了关于干扰素对丝裂霉素C诱发的姊妹染色单体互换频率和(或)对紫外线诱发的非合成期DNA合成的影响的研究。结果发现,4例正常人和3例着色性干皮病病人的淋巴细胞经干扰素处理后再用丝裂霉素C所诱发的姊妹染色单体互换频率显著地低于对照组,而2例正常人和2例着色性干皮病病人的淋巴细胞经干扰素处理后再用紫外线所诱发的非合成期DNA合成水平则与对照组相似。作者认为,干素扰可能具有抗变效应。     

50例正常人外周血淋巴细胞姐妹染色单体互换率(摘要)

近年来,关于姐妹染色单体互换(Sister Chromatid Exchange,以下简称SCE)的研究日益增多。普遍认为可利用SCE作为研究细胞动力学和检测环境致突变物或致癌物的灵敏指标。某些因素可对SCE频率有影响,如吸烟、饮酒、服药以及一些遗传性疾病,都能使SCE频率显著增加。本文