| Effects of Interferon on Mitomycin C-Induced Sister Chromatid Exchanges and on Ultraviolet Induced Unscheduled DNA Synthesis |
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| 作者姓名： | 王肖鹏 蒋左庶 胡以平 程浒君 杨连生 |
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| 作者单位： | Department of Biology Second Military Medical College，Shanghai，Department of Biology，Second Military Medical College，Shanghai，Department of Biology，Second Military Medical College，Shanghai，Department of Biology，Second Military Medical College，Shanghai，Department of Biology，Second Military Medical College，Shanghai |
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| 摘 要： | This article is about the effects of interferon(IFN)on sisterchromatid exchange(SCE)frequencies induced by mitomycin C(MMC)and/or unscheduled DNA synthesis(UDS)induced by ultra-violet light(UV).The result shows that SCE frequencies in peri-pheral lymphocytes from 4 normal individuals and 3 patients withxeroderma pigmentosum(XP)treated with IFN before the additionof MMC were much lower than those of the controls.But after thetreatment of IFN followed by UV irradiation,no difference was fo-und between the UDS levels of the lymphocytes from 2 normal in-dividuals and 2 patients with XP and those from the controls.Thewriters deduce that IFN may have some effect of antimutation
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Effects of Interferon on Mitomycin C-Induced Sister Chromatid Exchanges and on Ultraviolet Induced Unscheduled DNA Synthesis |
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| Wang Xiaopeng Jiang Zuoshu Hu Yiping Cheng Hujun Yang Liansheng.Effects of Interferon on Mitomycin C-Induced Sister Chromatid Exchanges and on Ultraviolet Induced Unscheduled DNA Synthesis[J].Journal of Medical Colleges of PLA(China),1986(4). |
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| Authors: | Wang Xiaopeng Jiang Zuoshu Hu Yiping Cheng Hujun Yang Liansheng |
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| Affiliation: | Wang Xiaopeng Jiang Zuoshu Hu Yiping Cheng Hujun Yang Liansheng Department of Biology,Second Military Medical College,Shanghai |
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| Abstract: | This article is about the effects of interferon(IFN)on sister chromatid exchange(SCE)frequencies induced by mitomycin C (MMC)and/or unscheduled DNA synthesis(UDS)induced by ultra- violet light(UV).The result shows that SCE frequencies in peri- pheral lymphocytes from 4 normal individuals and 3 patients with xeroderma pigmentosum(XP)treated with IFN before the addition of MMC were much lower than those of the controls.But after the treatment of IFN followed by UV irradiation,no difference was fo- und between the UDS levels of the lymphocytes from 2 normal in- dividuals and 2 patients with XP and those from the controls.The writers deduce that IFN may have some effect of antimutation |
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| Keywords: | xeroderma pigmentosum interferfons sister chromatid exchange DNA repair mutagens |
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