炉甘石洗剂的稳定性试验及处方筛选

目的：对5种处方的炉甘石洗剂进行稳定性试验，筛选该洗剂的最佳处方。方法：测定5种处方的沉降容积比并作重新分散试验。结果：1号处方的沉降容积比最大，稳定性最好。结论：炉甘石洗剂的最佳处方应是选择CMC－Na为稳定剂，才能在贮存和使用期间达到最佳效果。     

均匀设计在炉甘石洗剂处方中的应用

目的：筛选炉甘石洗剂中羧甲基纤维素纳（CMC—Na）和吐温-80（Tween-80）的最佳用量,增加炉甘石洗剂的稳定性。方法：将均匀设计应用到炉甘石洗剂稳定剂用量的优化试验中,采用沉降容积比为指标考察其稳定性。结果：根据均匀设计优化CMC—Na和吐温-80的处方用量分别为0．12g.0．22g。结论：均匀设计方法简便,稳定性好,可用于炉甘石洗剂处方中稳定剂用量的筛选。     

炉甘石洗剂的配制及稳定性观察

本文采用分散法制备炉甘石洗剂观察其稳定性。评价几种稳定剂对炉甘石洗剂的混悬效果或絮凝效果,从中找到了适用于炉甘石洗剂较好的助悬剂或絮凝剂。     

炉甘石洗剂处方中稳定剂的改进

本文对国内目前现行炉甘石洗剂处方中的稳定剂进行改进,增加了三氯化铝作为絮凝剂,以提高炉甘石洗剂的稳定性.通过稳定性试验,证明改进后的处方其制剂稳定性比关原大为提高.(P<0.01)     

消银片联合二硫化硒洗剂治疗寻常型痤疮疗效分析

目的：探究消银片联合二硫化硒洗剂治疗寻常型痤疮的临床效果。方法随机选取该院收治的寻常型痤疮患者220例，随机分为对照组和观察组。对照组患者仅予二硫化硒洗剂进行治疗，观察组患者采用消银片联合二硫化硒洗剂进行治疗。比较两组用药后的效果和不良反应情况。结果观察组治疗总有效率明显高于对照组，不良反应发生率显著低于对照组，两组比较差异均具有统计学意义(P<0.05)。结论消银片联合二硫化硒洗剂治疗寻常型痤疮相比于单用二硫化硒洗剂，不仅疗效更优，而且能够减小不良反应的出现风险。     

穴位埋线联合中药外洗剂治疗轻中度痤疮的临床疗效观察

目的观察穴位埋线联合中药外洗剂治疗轻中度痤疮的临床疗效。方法将70例痤疮患者随机分为治疗组35例,对照组35例。治疗组采用穴位埋线联合中药外洗剂治疗,对照组采用中药外洗剂治疗,穴位埋线一周一次,3次为一个疗程,中药外洗剂每天两次,3周为一个疗程,一个疗程后观察疗效。结果治疗组总有效率88.57%,对照组总有效率57.14%,治疗组和对照组治疗前后的总有效率相对比,有统计学意义(P 0.05)。结论穴位埋线联合中药外洗剂治疗轻中度痤疮有明显疗效。     

复方炉甘石洗剂助悬剂的筛选

本实验采用正交实验设计的方法考查了炉甘石洗剂采用３种常用助悬剂和一种润湿剂对其稳定性的影响，结果表明，助悬剂羧甲基纤维素钠、淀粉、枸橼酸钠对炉甘石洗剂的稳定性有极显著影响。     

清热解毒化痰散结方对聚合性痤疮患者雄激素受体的影响

目的观察清热解毒化痰散结方对聚合性痤疮患者皮损内白细胞雄激素受体（AR）的影响。方法选取临床诊断为聚合性痤疮并符合中医痰热互结证型的患者126例,采用不平衡指数法结合患者就诊顺序分为治疗组42例,予清热解毒化痰散结方内服配合外用自拟痤疮洗剂（金银花等）;对照1组42例,予内服美满霉素治疗配合外用自拟痤疮洗剂;对照2组42例,单纯外用自拟痤疮洗剂。用免疫组化方法检测每组患者治疗前后皮损处的白细胞雄激素受体。结果治疗组治疗后的AR阳性率低于治疗前（P〈0.05）,且治疗组的AR阳性率与对照组1组、对照2组相比,差异均有统计学意义（P〈0.05）。结论清热解毒化痰散结方降低聚合型痤疮患者的AR明显优于西药组及单纯外治组,为清热解毒散结法治疗痤疮提供了依据。     

几种助悬剂对炉甘石洗剂助悬性能的考察

目的:选择配制炉甘石洗剂时最佳的助悬剂.方法:在同一剂量的处方中加入不同的助悬剂,观察炉甘石洗剂的稳定性.结果:相同时间内,沉淀高度因助悬剂不同而不同.结论:配制炉甘石洗剂时应选用羧甲基纤维素钠+硅皂土作为助悬剂.     

功能高分子微球研究分散聚合法合成μ级聚苯乙烯微球

微米级聚苯乙烯微球广泛用于临床分析、生物医学、胶体研究等领城,亦可作为电子显微镜、光散射、沉降法等测定微小物体绝对长度的基准物、色谱柱填料等。用分散聚合法可以制得微米级单分散聚苯乙烯微球。本文通过对分散聚合条件和配方的研究,以水和醇为分散介质,分子量4000的聚乙二醇为稳定剂,过氧化苯甲酰为引发剂,合成了粒径为3至4μm的单分散聚苯乙烯微球。在分散聚合体系中,随着有机溶剂、单体、引发剂等用量的增加,胶乳粒径增大,粒径分布变宽。随着稳定剂、表面张力调节剂等用量的增加,胶乳粒径减小,粒径分布变窄。有机溶剂种类改变以及聚合反应温度变化,胶乳粒径也发生变化。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Dr.Zhang Ren's Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.