近10年来正清风痛宁治疗漏肩风病的研究进展

目的为了阐明正清风痛宁治疗漏肩风病的机理及临床疗效,同时也为临床更好地应用正清风痛宁治疗漏肩风病提供可靠并且有效的依据。方法通过检索中国知网、万方以及维普等全文数据库,以"正清风痛宁和漏肩风病/肩周炎/肩凝症/冻结肩"为检索式,以"篇名/主题词/关键词"为检索途径,检索了2007至2017年的相关文献,并对这些文献进行了归纳与总结。结果共检索到23篇文献,其中有关正清风痛宁的文献8篇,单独运用正清风痛宁治疗漏肩风病的文献6篇,正清风痛宁结合其他不同疗法治疗漏肩风病的文献9篇。结论正清风痛宁治疗漏肩风病是确实有效果的,值得临床上进一步推广及应用。     

Effect of moxibustion stimulation on repair of injured gastric mucosa after common peroneal nerve transection

Objective

To investigate the protective effect of moxibustion in initiating the endogenous protection information on gastric mucosa, and its relationship with the pathway of common peroneal nerve.

Methods

Forty-eight Sprague-Dawley (SD) rats were randomly divided into a normal group (group A), a model group (group B), a moxibustion model group (group C) and a moxibustion model plus surgery group (group D), 12 in each group. Except for group A, rats in the other groups were treated with dehydrated ethanol and aspirin to prepare gastric mucosal damage model. The rats in group B were not treated with any interventions; rats in group C received moxibustion at Zusanli (ST 36), twice a day for continuous 3 d. The rats in group D were subjected to preparing the gastric mucosal damage model after the common peroneal nerve transection, followed by moxibustion at Zusanli (ST 36). After a 3-day intervention, ulcer index (UI) in each group was observed, and the levels of gastric mucosa-related repair cytokines of tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4) and heat shock protein 70 (HSP70) were detected.

Results

Compared with group A, the pathological changes and UI of group B were worse (P=0.000), but TNF-α in serum and tissue was changed significantly (P=0.000, P=0.002), IL-4 in serum and tissue was improved significantly (P=0.000, P=0.000). Compared with group B, TNF-α and IL-4 in group C and group D were significantly improved (TNF-α: P=0.003, P=0.016; IL-4: P=0.000, P=0.002). Compared with group C, the changes of UI in group B and group D were poor (both P=0.000); the levels of TNF-α and IL-4 in serum were significantly decreased (TNF-α: P=0.000, P=0.025; IL-4: P=0.000, P=0.034); and tissue HSP70 levels were decreased significantly (P=0.000, P=0.033).

Conclusion

Zusanli (ST 36) can transmit information through the pathway of common peroneal nerve, regulate the release of gastric mucosal protective factors, and up-regulate the expression of cytothesis-related proteins, so as to achieve the effect in repairing gastric mucosa.

     

孤束核损毁术后艾灸足三里穴对胃黏膜损伤模型大鼠TNF-α、NO和HSP70表达的影响

目的:观察孤束核捣毁术后艾灸"足三里"穴对胃黏膜损伤模型大鼠肿瘤坏死因子α(TNF-α)、血清一氧化氮(NO)与热休克蛋白(HSP70)表达的影响,并分析在艾灸保护胃黏膜损伤的神经通路中孤束核所起的作用。方法:将SD大鼠48只随机分为正常组(A组)、模型组(B组)、艾灸+模型组(C组)、艾灸+模型+孤束核损毁组(D组),每组12只,无水乙醇灌胃造成胃黏膜损伤,并用阿司匹林混悬液连续灌胃3d维持损伤(A组予0.9%氯化钠注射液灌胃),按Guth法计算胃黏膜损伤指数(UI),采用ELISA法检测胃黏膜细胞凋亡相关因子TNF-α、NO含量,并采用Western-blot法检测大鼠胃黏膜组织中保护蛋白HSP70的含量。结果:B组胃黏膜出现明显损伤,表明采用无水乙醇灌胃及阿司匹林悬浊液灌胃法造模成功(P0.05);C、D组UI指数较B组均有不同程度的下降(P0.01,P0.05),D组UI指数较C组高(P0.01)。C、D组胃黏膜组织中TNF-α含量较B组均有不同程度的下降,NO含量均有上升(P0.05,P0.01);D组胃黏膜组织中TNF-α含量较C组高,而NO含量较C组低(P0.01)。胃黏膜保护蛋白HSP70的表达C、D组较B组均有明显上升(P0.01),同时D组的表达较C组低(P0.05)。结论:艾灸足三里穴对胃黏膜损伤有明显的保护性调节作用,而孤束核损毁后其保护效应受到明显抑制,证明对大鼠足三里穴进行温和灸后产生胃黏膜保护机制非常重要的传导中枢是孤束核。     

浮针配合董氏奇穴治疗腰背筋膜炎35例

目的:观察浮针配合董氏奇穴治疗腰背筋膜炎的临床疗效。方法:选取2014年1月至2016年1月长沙市按摩骨科医院特色门诊部收治的腰背筋膜炎患者35例,所有患者均给予浮针配合董氏奇穴治疗。结果:35例患者中,治愈22例,显效8例,好转3例,无效2例,有效率为94.4%。结论:浮针配合董氏奇穴治疗腰背肌筋膜炎临床疗效显著。     

艾灸“足三里”对胃黏膜损伤大鼠内源性保护因子含量及相关蛋白表达的影响

目的观察艾灸"足三里"穴对孤束核损毁术后胃黏膜损伤大鼠内源性保护因子含量及相关蛋白的表达,探讨孤束核在艾灸保护胃黏膜损伤神经通路中的作用。方法按随机数字表法将48只健康SPF级SD大鼠分为4组:正常对照组,模型组,艾灸+模型组(艾灸组),艾灸+模型+孤束核损毁组(艾灸加孤束核损毁组),每组各12只。其中艾灸加孤束核损毁组予双侧孤束核损毁,护理3 d后,模型组和艾灸组大鼠均以无水乙醇(6 m L/kg)灌胃造模,并用阿司匹林混悬液(200 mg/kg)连续3 d灌胃以维持胃黏膜损伤,正常对照组用等量生理盐水灌胃,第4天进行艾灸"足三里"处理(正常对照组和模型组只绑不灸),每日2次,连续3 d。取血清及胃组织,计算胃黏膜损伤指数(UI),用ELISA法检测胃黏膜组织中表皮生长因子(EGF)、一氧化氮(NO)含量,用Western-blot法检测胃黏膜组织中抗凋亡蛋白(Bcl-2)、凋亡蛋白(Bax)的蛋白表达情况。结果与正常对照组比较,模型组胃黏膜损伤明显(P0.05);艾灸组UI较模型组下降(P0.05)。与模型组比,艾灸组血清、胃组织EGF、NO含量明显升高(均P0.05);艾灸加孤束核损毁组血清、胃组织EGF、NO含量较艾灸组低(均P0.05)。艾灸组和艾灸加孤束核损毁组Bcl-2蛋白表达较模型组有明显上升,而Bax表达明显下降(P0.05),细胞凋亡指数(AI)比值上升(P0.05)。结论艾灸足三里穴可调节机体内源性保护因子及蛋白的表达,保护胃黏膜,并受孤束核损毁的影响。证明孤束核是艾灸足三里穴产生胃黏膜保护效应信号传导通路中的重要调节部位。     

针灸治疗神经根型颈椎病研究概况

正颈椎病是一种颈椎退行性疾病,颈椎间盘及颈椎附件退变是本病的内因,各种急慢性颈部外伤和受寒是导致本病的外因。颈椎病属中医学"眩晕""痹症"等范畴,其发生常与伏案久坐、跌扑损伤、外邪侵袭或年迈体弱、肝肾不足等有关~([1])。临床上颈椎病通常分为4型:神经根型、脊髓型、椎动脉型、交感神经型。神经根型颈椎病是颈椎病四型     

刃针与浮针治疗腰三横突综合征的研究进展

正腰三横突综合征(Third lumbar trans-verse process syndrome)主要表现为第三腰椎横突周围组织的损伤,导致慢性腰痛,第三腰椎横突处明显压痛~([1-2])。腰椎横突中L3横突最长且L3椎体位于5个椎体中心,是腰椎前屈后伸及左右旋转的活动枢纽,在超负荷负重及扭挫伤时,极易使附着的韧带、肌肉、筋膜受到损伤,导致痛性肌痉挛,进而刺激或压迫脊神经后支的外侧支,引起横突部及臀、股部的疼     

湖湘针推学派“推五经,调五脏”治疗小儿盗汗

湘西刘氏小儿推拿是我国小儿推拿重要流派之一,其源于湖南省湘西著名老中医刘开运教授祖传苗医小儿推拿技术,主要学术特色是"五经推治,五经配伍,推经治脏"。刘氏小儿推拿在治疗小儿盗汗的临床疗效显著,治疗时多用到清或者补五脏经的手法,具有滋补肾水、养心清火、健脾益气、调和营卫等功效。同时小儿推拿作为中医儿科最常见的一种绿色疗法,免去服药困难,同时具有疗程短,操作简便疗效高,费用低,无不良反应的特点,容易被患者接受的特点,对中医学治疗小儿盗汗有深远意义。