人类白细胞抗原G在宫颈癌组织中的表达及临床意义

目的探讨人类白细胞抗原G（human leukocyte antigenG,HLA—G）在宫颈癌组织中的表达及其临床意义。方法应用S—P免疫组织化学方法检测于2006年1月-2011年12月就诊我院的98例宫颈鳞癌患者术后病理标本,并分析HLA—G的表达与病理参数之间的关系。结果HLA—G分子在宫颈癌组织中表达率为43．9％（43／98）,而在癌旁正常宫颈组织的表达率为0。HLA—G分子表达与淋巴结转移、脉管浸润有相关性（P〈0．01）。结论HLA—G分子在宫颈癌组织中表达上调,并与宫颈癌的侵袭性生长相关。HLA—G分子参与肿瘤细胞免疫逃逸过程,促进肿瘤的发生和发展。     

Ⅰ期子宫内膜样腺癌前哨淋巴结活检术学习曲线分析#br# #br#

【Abstract】?Objective?To explore learning curve of sentinel lymph node biopsy (SLNB) for stage I endometrioid adenocarcinoma. Methods?Sixty patients with stageⅠendometrioid adenocarcinoma from October 2015 to June 2018 were selected and divided into three groups according to the order of operation time: Group A (October 2015 to December 2016), Group B (December 2016 to February 2018) and Group C (February 2018 to June 2018). There were 20 patients in each group. The SLNB operation time, detection rate, and sensitivity were compared. Results?The operation time of SLNB in group C was significantly shorter than groups A and B (P<0.05). Among the 60 patients, 51 (85%) were successful SLN mapping, 43(71.67%) bilaterally SLN mapping, 47 (78.33%) were external iliac lymph nodes, 31 (51.67%) were obturator lymph nodes. The rate of group A, B, and C was 70% (14/20), 90% (18/20), and 95% (19/20), respectively. The difference between the total detection rates of three groups was statistically significant (P=0.021). The sensitivity of SLNB in group A was 50%, and the negative predictive value was 92.30%, and both groups B and C were 100%. Conclusion?There is a learning curve for SLNB. After 40 cases of SLNB, more proficient and accurate level can be achieved.     

闲话“春节”

<正> 节日,是人类社会发展到一定阶段的产物。其形成是一个历史沉淀的过程。它反映着一定时期人们的生活方式、审美情趣、价值观念和思维特征。在中国的传统节日中,最能体现这一民族文化特点的,莫过于“年文化”了。在过年的日子里,生活被     

血浆脑钠肽检测在心力衰竭诊断中的应用评价

目的:探讨血浆脑钠肽(brain natriuretic peptide,BNP)检测在心力衰竭(心衰)诊断中的应用价值。方法:选取心衰患者71例为观察组,同时选取71例健康体检者为对照组,比较两组血浆BNP、左心室射血分数(left ventricular ejection fraction,LVEF)、不同心功能分级BNP水平及阳性检出情况。结果:观察组LVEF比对照组低,血浆BNP水平比对照组高,差异均有统计学意义(P<0.05);观察组心功能Ⅰ级患者血浆BNP阳性检出率53.33%,Ⅱ级阳性检出率76.47%,Ⅲ级阳性检出率95.00%,Ⅳ级阳性检出率100.00%;心功能Ⅳ级患者血浆BNP水平高于Ⅲ级、Ⅱ级及Ⅰ级患者,差异均有统计学意义(t=36.535、24.466、19.305,均P<0.05);心功能Ⅲ级患者血浆BNP水平高于Ⅰ级患者,差异有统计学意义(t=2.732,P<0.05);但心功能Ⅱ级患者血浆BNP水平与Ⅰ级和Ⅲ级比较,差异均无统计学意义(t=1.904、1.104,均P>0.05)。结论:血浆BNP检测在心衰诊断中效果较好,有助于早期诊断,且心衰越严重其阳性检出率与检测值越高。     

注射用环磷腺苷葡胺治疗老年心力衰竭的临床疗效观察

目的观察并分析临床中运用环磷腺苷葡胺对老年心力衰竭患者进行治疗的效果。方法本院近年来共收治老年心力衰竭患者100例,并以此作为临床资料,对患者运用环磷腺苷葡胺进行治疗,观察临床效果。结果在对患者运用环磷腺苷葡胺进行治疗之后,患者的检测指标均有很大程度的提升,其中包括患者每搏输血量等。结论临床中运用环磷腺苷葡胺对老年心力衰竭患者进行治疗,能够显著提升患者的心肌功能,治疗效果较为明显。     

侵袭性和非侵袭性胸腺瘤的CT鉴别诊断

目的 :评价CT对侵袭性和非侵袭性胸腺瘤的鉴别诊断价值。方法 :由两位放射科医师采用双盲法对 2 9例侵袭性胸腺瘤和 2 4例非侵袭性胸腺瘤进行单独评价 ,分析CT诊断侵袭性或非侵袭性胸腺瘤的可靠性 ,并与手术病理结果对照。结果 :侵袭性胸腺瘤 ( 2 1例 ,占 72 %)较非侵袭性胸腺瘤 ( 7例 ,占 2 9%)有明显的分叶 (P <0 .0 5 )。侵袭性胸腺瘤囊变率 ( 2 3例 ,占 79%)较非侵袭性胸腺瘤 ( 6例 ,占 2 3 %)高 (P <0 .0 1) ;侵袭性胸腺瘤增强后较非侵袭性胸腺瘤有明显强化。结论 :肿瘤边缘分叶或不规则、囊变或坏死、增强前后CT值相差 2 0HU、纵隔脂肪线消失等CT征象提示侵袭性胸腺瘤。