鼻塞式持续呼吸道正压给氧在小儿重症肺炎合并呼吸衰竭中的临床应用价值分析

目的:探讨鼻塞式持续呼吸道正压给氧在小儿重症肺炎合并呼吸衰竭中的应用效果。方法:选取2009～2010年于该院进行治疗的38例小儿重症肺炎合并呼吸衰竭患者为研究对象,将其随机分为对照组(鼻导管给氧组)19例和观察组(鼻塞式持续呼吸道正压给氧组)19例,将两组患者总有效率、治疗前后的血气分析指标及机械通气率、家长满意率进行统计及比较。结果:观察组治疗总有效率及家长满意率均高于对照组,机械通气率低于对照组,血气分析指标改善优于对照组,P值均<0.05,有统计学差异。结论:鼻塞式持续呼吸道正压给氧在小儿重症肺炎合并呼吸衰竭中的应用效果较佳,可改善血气分析及降低机械通气率。     

白三烯受体拮抗剂联合吸入糖皮质激素治疗儿童感染后咳嗽

目的：探讨白三烯受体拮抗剂孟鲁司特联合吸入糖皮质激素治疗儿童感染后咳嗽的临床效果。方法：选取我院儿科2009年6月～2010年12月收治的178例感染后咳嗽的患儿，按其所采用的治疗方法不同分为二组，观察组89例患儿采用白三烯受体拮抗剂孟鲁司特联合吸入糖皮质激素进行治疗；对照组89例患儿采用吸入糖皮质激素治疗，比较两组患...     

纤维支气管镜肺泡灌洗术治疗儿童支原体肺炎疗效观察

目的探讨纤维支气管镜肺泡灌洗术治疗儿童支原体肺炎的临床疗效。方法选择2009年4月—2014年3月我院儿童呼吸科收治的194例肺炎患儿,病原学结果显示均为肺炎支原体感染。按入院顺序单双号分为观察组和对照组,每组97例,对照组患儿给予清热减毒、化痰止咳、大环内酯类抗生素抗感染等常规治疗,观察组在此基础上采用支气管肺泡灌洗术治疗。对比观察2组临床疗效和症状、体征改善情况。结果观察组总有效率为92．8％,对照组总有效率为77．3％,2组比较差异有统计学意义（P〈0．05）;观察组咳嗽持续时间、发热持续时间、肺部体征消失时间、肺部x线吸收时间和住院时间均显著短于对照组,差异有统计学意义（P〈0．05）。结论纤维支气管镜肺泡灌洗术治疗儿童支原体肺炎疗效显著,可以迅速改善患儿症状体征,值得进一步深入研究。     

幼年大鼠溺水应激后胰岛素信号传导变化及外源胰岛素治疗反应

Objective To explore the alteration of insulin signal transduction in drowning-induced stress hyperglycemia and to investigate therapeutic effect of insulin on it.Methods Stress hyperglycemia model was induced by drowning.Thirty-two infant rats were randomized into control,drowning,air resuscitation and air-insulin resuscitation groups.Insulin was injected abdominally into the air-insulin resuscitation rats.Fasting serum glucose and insulin were determined routinely,and protein expressions and serine phosphorylation levels of insulin receptor substrate 1(IRS-1) in muscle tissue were detected by Western blot and immunoprecipitation.The expressions of glucose transporter 4(GLUT4) in the intracellular and plasma membranes of muscle tissue were detected by Western blot.Results In the drowning group,insulin resistance index(HOMA-IR) increased significantly as compared with that of the control group,but the level of IRS-1 had no significantly change as compared with the other three groups.As compared with that of the drowning group(0.71±0.12),IRS-1 serine phosphorylation levels of the two resuscitation groups decreased significantly(0.56±0.13 and 0.46±0.08 respectively).The intracellular GLUT4 expression in the two resuscitation groups(1.82±0.11 and 1.96±0.28 respectively)increased significantly in contrast to that of the drowning group(1.45±0.15),and the air-insulin resuscitation groups showed an especially high increase of intracellular GLUT4 expression.Conclusion During the drowning-induced stress hyperglycemia,the alteration of serine phosphorylation and GLUT4 distribution is one of the important mechanism of insulin resistance.Insulin may decrease the blood glucose through decreasing serine phosphorylation levels of IRS-1 and increasing the intracellular GLUT4 expressions.     

争光霉素治疗翼状胬肉52例疗效观察

争光霉素治疗翼状胬肉５２例疗效观察苏州市第七人民医院徐惠良１９９０～１９９２年我院用争光霉素局部注射法治疗进行性翼状肉５２例，疗效满意，现介绍如下。一、病例；男２８例，女２４例。年龄３１～６１岁。二、分型标准：根据　肉大小划分，小：侵及角膜缘内＜２ｍ...     

幼年大鼠溺水应激后胰岛素信号传导变化及外源胰岛素治疗反应

Objective To explore the alteration of insulin signal transduction in drowning-induced stress hyperglycemia and to investigate therapeutic effect of insulin on it.Methods Stress hyperglycemia model was induced by drowning.Thirty-two infant rats were randomized into control,drowning,air resuscitation and air-insulin resuscitation groups.Insulin was injected abdominally into the air-insulin resuscitation rats.Fasting serum glucose and insulin were determined routinely,and protein expressions and serine phosphorylation levels of insulin receptor substrate 1(IRS-1) in muscle tissue were detected by Western blot and immunoprecipitation.The expressions of glucose transporter 4(GLUT4) in the intracellular and plasma membranes of muscle tissue were detected by Western blot.Results In the drowning group,insulin resistance index(HOMA-IR) increased significantly as compared with that of the control group,but the level of IRS-1 had no significantly change as compared with the other three groups.As compared with that of the drowning group(0.71±0.12),IRS-1 serine phosphorylation levels of the two resuscitation groups decreased significantly(0.56±0.13 and 0.46±0.08 respectively).The intracellular GLUT4 expression in the two resuscitation groups(1.82±0.11 and 1.96±0.28 respectively)increased significantly in contrast to that of the drowning group(1.45±0.15),and the air-insulin resuscitation groups showed an especially high increase of intracellular GLUT4 expression.Conclusion During the drowning-induced stress hyperglycemia,the alteration of serine phosphorylation and GLUT4 distribution is one of the important mechanism of insulin resistance.Insulin may decrease the blood glucose through decreasing serine phosphorylation levels of IRS-1 and increasing the intracellular GLUT4 expressions.     

幼年大鼠溺水应激后胰岛素信号传导变化及外源胰岛素治疗反应

Objective To explore the alteration of insulin signal transduction in drowning-induced stress hyperglycemia and to investigate therapeutic effect of insulin on it.Methods Stress hyperglycemia model was induced by drowning.Thirty-two infant rats were randomized into control,drowning,air resuscitation and air-insulin resuscitation groups.Insulin was injected abdominally into the air-insulin resuscitation rats.Fasting serum glucose and insulin were determined routinely,and protein expressions and serine phosphorylation levels of insulin receptor substrate 1(IRS-1) in muscle tissue were detected by Western blot and immunoprecipitation.The expressions of glucose transporter 4(GLUT4) in the intracellular and plasma membranes of muscle tissue were detected by Western blot.Results In the drowning group,insulin resistance index(HOMA-IR) increased significantly as compared with that of the control group,but the level of IRS-1 had no significantly change as compared with the other three groups.As compared with that of the drowning group(0.71±0.12),IRS-1 serine phosphorylation levels of the two resuscitation groups decreased significantly(0.56±0.13 and 0.46±0.08 respectively).The intracellular GLUT4 expression in the two resuscitation groups(1.82±0.11 and 1.96±0.28 respectively)increased significantly in contrast to that of the drowning group(1.45±0.15),and the air-insulin resuscitation groups showed an especially high increase of intracellular GLUT4 expression.Conclusion During the drowning-induced stress hyperglycemia,the alteration of serine phosphorylation and GLUT4 distribution is one of the important mechanism of insulin resistance.Insulin may decrease the blood glucose through decreasing serine phosphorylation levels of IRS-1 and increasing the intracellular GLUT4 expressions.     

幼年大鼠溺水应激后胰岛素信号传导变化及外源胰岛素治疗反应

目的 探讨溺水应激大鼠的胰岛素信号转导变化及外源胰岛素治疗反应.方法 采用溺水的方法建立应激性高血糖动物模型,32只幼年大鼠随机分为对照组、溺水窒息组、空气复苏组、空气复苏联合胰岛素治疗组.空气复苏联合胰岛素治疗组在复苏时注射胰岛素.在溺水并复苏过程中测定大鼠血糖、胰岛素、骨骼肌胰岛素受体底物1(IRS-1)及其丝氨酸磷酸化水平,检测骨骼肌内外膜的葡萄糖转运体4(GLUT4)蛋白含量.结果 溺水组胰岛素抵抗指数升高,产生严重的胰岛素抵抗,IRS-1含量无显著改变;空气复苏组与空气复苏联合胰岛素治疗组的IRS-1丝氨酸磷酸化水平(分别为0.56±0.13、0.46±0.08)均低于溺水窒息组(0.71±0.12),差异有显著性(P＜0.05);外膜的GLUT4蛋白含量(分别为1.82±0.11、1.96±0.28)显著高于溺水窒息组(1.45±0.15),尤以空气复苏联合胰岛素治疗组的变化更为显著.结论 在溺水窒息导致的应激性高血糖过程中,IRS-1丝氨酸磷酸化、GLUT4表达异常是胰岛素抵抗的重要调控点之一.胰岛素能改善IRS-1丝氨酸磷酸化及GLUT4内外膜分布,达到降低血糖的作用.     

思密达治疗新生儿高胆红素血症30例疗效观察

新生儿高胆红素血症(下简称高胆)常见原因为感染、新生儿溶血、母乳性黄疸、新生儿窒息。为寻求方便而有效的治疗方法,1998年我院采用思密达治疗30例,疗效满意,报道于下。1　临床资料1.1　病例　60例,思密达治疗组和对照组各30例。皆符合高胆的诊断标准[1]:足月新生儿血清...     

法英替丁治疗眼部带状疱疹28例疗效观察

法英替丁治疗眼部带状疱疹２８例疗效观察苏州市第七人民医院徐惠良法莫替了为新型的组胺Ｈ２受体阻滞剂，作用强度超过西米替了和雷尼替丁，其不良反应甚少［１］．近年来作者用法莫替丁治疗眼部带状疱疹２８例，效果较好，报告如下。一、病例：４８例是随机分为２组。治...