Pregnancy by Assisted Reproductive Technology Is Associated with Shorter Telomere Length in Neonates

Telomere length (TL) influences the development of lifestyle-related diseases, and neonatal TL may influence their prevalence. Various factors have been reported to affect neonatal TL. Although the fetus is exposed to multiple conditions in utero, the main factors affecting the shortening of neonatal TL are still not known. In this study, we sought to identify factors that influence fetal TL. A total of 578 mother-newborn pairs were included for TL analysis. TL was measured in genomic DNA extracted from cord blood samples using quantitative PCR. The clinical factors examined at enrollment included the following intrauterine environmental factors: maternal age, assisted reproductive technology (ART) used, body mass index (BMI), gestational diabetes mellitus (GDM), maternal stress, smoking, alcohol consumption, preterm delivery, small-for-gestational-age, neonatal sex, and placental weight. Univariate and multivariate regression analyses were used to verify the relationship between neonatal TL and these clinical factors. The median neonatal TL to single-copy gene ratio was 1.0. Pregnancy with ART was among the 11 factors associated with shorter neonatal TL. From multiple regression analysis, we determined that neonatal TL was significantly shorter for pregnancies in the ART group than in the other groups. We conclude that pregnancy with ART is associated with shorter neonatal TL.     

Possibility of Japanese Cedar Pollen Causing False Positives in the Deep Mycosis Test

Because Japanese cedar pollen (JCP) contains beta-1,3-d-glucan (BG), there is concern that its lingering presence in the atmosphere, especially during its scattering period, may cause false positives in the factor-G-based Limulus amebocyte lysate (LAL) assay used to test for deep mycosis (i.e., G-test). Hence, we examined whether the LAL assay would react positively with substances contained in JCP by using the G-test to measure JCP particles and extracts. BG was purified from the JCP extract on a BG-specific affinity column, and the percentage extractability was measured using three different BG-specific quantitative methods. The G-test detected 0.4 pg BG in a single JCP particle and 10 fg from a single particle in the extract. The percentage extractability of JCP-derived BG was not significantly different among the three quantitative methods. As the JCP particles should technically have been removed during serum separation, they should be less likely to be a direct false-positive factor. However, given that the LAL-assay-positive substances in the JCP extract were not distinguishable by the three BG-specific quantitative methods, we conclude that they may cause the background to rise. Therefore, in Japan false positives arising from JCP contamination should be considered when testing patients for deep mycosis.     

A Terahertz Video Camera Patch Sheet with an Adjustable Design based on Self-Aligned, 2D,Suspended Sensor Array Patterning

Terahertz (THz) imaging is expected to become powerful tools for non-destructive inspections. To ensure the practical use of THz non-destructive monitoring, versatile THz imagers with adjustable designs that can eliminate the complexities and the bulkiness of the device are urgently required. Herein, a self-aligned filtration process for a 2D, free-standing carbon nanotube film array and its application to a THz video camera patch are reported. The presented techniques enable a) to freely design the camera size, sensor array pattern, and suspended shape according to its applications, b) to cut the camera patch into desired shapes, and c) to attach them to the objects that are intended to be measured. Real-time, non-destructive monitoring of various infrastructures is demonstrated. These results indicate that it can function regardless of restrictions, such as the shapes and locations of the measurement samples, thus providing a strong possibility for use in future non-destructive sensor networks.     

The Potential Role of Hepatocyte Growth Factor in Degenerative Disorders of the Synovial Joint and Spine

This paper aims to provide a comprehensive review of the changing role of hepatocyte growth factor (HGF) signaling in the healthy and diseased synovial joint and spine. HGF is a multifunctional growth factor that, like its specific receptor c-Met, is widely expressed in several bone and joint tissues. HGF has profound effects on cell survival and proliferation, matrix metabolism, inflammatory response, and neurotrophic action. HGF plays an important role in normal bone and cartilage turnover. Changes in HGF/c-Met have also been linked to pathophysiological changes in degenerative joint diseases, such as osteoarthritis (OA) and intervertebral disc degeneration (IDD). A therapeutic role of HGF has been proposed in the regeneration of osteoarticular tissues. HGF also influences bone remodeling and peripheral nerve activity. Studies aimed at elucidating the changing role of HGF/c-Met signaling in OA and IDD at different pathophysiological stages, and their specific molecular mechanisms are needed. Such studies will contribute to safe and effective HGF/c-Met signaling-based treatments for OA and IDD.     

Verification of Iron Loss Calculation Method Using a High‐Precision Iron Loss Analyzer

Because of the improved performance of power devices, the volume of the ac filter inductors used in high‐frequency PWM inverters has been reduced. However, the temperature rise in the filter inductor due to this miniaturization has become more pronounced. Therefore, we have proposed an iron loss calculation method for the ac filter inductor. However, the accuracy of the value calculated via the loss map method cannot be verified, because the iron loss arising during each switching period cannot be measured with conventional power measuring instruments. In order to resolve this problem, we developed an inductor loss analyzer (ILA), which allows precise measurement of the iron loss in the inductor during each switching period. The accuracy of the calculation of iron loss in the filter inductor by the loss map method was verified with the ILA. We found that the value calculated by the loss map method differed slightly from the value measured with the ILA. However, these differences can be reduced if we take into account the accurate flux density calculation and the effect of the duty ratio of PWM pulses on the loss. Finally, we verified that the loss map method can provide accurate iron loss calculations.     

Fundamental Evaluation of Power Supply and Rectifiers for Wireless Power Transfer Using Magnetic Resonant Coupling

This paper provides a fundamental analysis of a power supply and rectifiers for wireless power transfer using magnetic resonant coupling (MRC). MRC enables efficient wireless power transfer over middle‐range transfer distances. MRC for wireless power transfer should operate at a high frequency in the industry science medical band, such as 13.56 MHz, because the size of the transfer device decreases at higher transfer frequencies. Therefore, the output frequency of the power supply on the transmitting side should be 13.56 MHz. In addition, the rectifier on the receiving side is operated at a high frequency. This paper focuses on the reflected power in the power supply and rectifiers. Thus, the parametric design method is clarified for the power supply, including a low‐pass filter to match the output, the impedance of the power supply with the characteristic impedance of the transmission line. In addition, the effects on the rectifiers of silicon carbide and gallium nitride diodes are confirmed by performing an experiment and a loss analysis.     

Modeling thermal behaviors of window flame ejected from a fire compartment

A series of reduced-scale experiments were carried out in order to investigate thermal behaviors of window flame, which exposes the upper floors as well as the adjacent buildings to potential risks of fire spread. A stainless pan filled with alcohol was used as the fire source and was placed inside a cubic compartment of 900 mm side. Temperatures and velocities at various points inside and outside of the compartment were measured. The compartment was pressurized during the experiment by mechanically supplying air at several mass inflow rates through an inlet duct set at the bottom part of the compartment. This was for simulating fire conditions under the effect of external wind pressure. On the basis of the experimental observation, line (i.e., two-dimensional) heat source assumption was adopted for developing a model of window flame behavior. A dimensionless parameter Q^′*${Q^{\prime }}^{*}$ was derived from the governing differential equations in order to generalize the measurement results. Expressions for temperature rise along the trajectory ΔT_m and characteristic flame width b_T were developed incorporating the parameter Q^′*${Q^{\prime }}^{*}$.     

A Study of Mutual Coupling between Vertical Grounding Electrodes

This paper investigates the mutual grounding impedance between vertical grounding electrodes based on field measurements and FDTD simulations. In the case of vertical electrodes, the mutual impedance between the electrodes is almost completely independent of the electrode length, and thus the induced voltage is nearly constant as the electrode length becomes longer. This characteristic is different from that of an overhead conductor, where the electromagnetic‐induced voltage is proportional to the conductor length. The greater the separation distance between the electrodes, the smaller the induced voltage, as in the case of an overhead conductor. The propagation speed increases as the separation increases. It is found that the speed is not necessarily proportional to the inverse of the relative permittivity of the earth.