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排序方式: 共有97条查询结果,搜索用时 15 毫秒
1.
Hitoshi Tonomura Masateru Nagae Ryota Takatori Hidenobu Ishibashi Tomonori Itsuji Kenji Takahashi 《International journal of molecular sciences》2020,21(22)
This paper aims to provide a comprehensive review of the changing role of hepatocyte growth factor (HGF) signaling in the healthy and diseased synovial joint and spine. HGF is a multifunctional growth factor that, like its specific receptor c-Met, is widely expressed in several bone and joint tissues. HGF has profound effects on cell survival and proliferation, matrix metabolism, inflammatory response, and neurotrophic action. HGF plays an important role in normal bone and cartilage turnover. Changes in HGF/c-Met have also been linked to pathophysiological changes in degenerative joint diseases, such as osteoarthritis (OA) and intervertebral disc degeneration (IDD). A therapeutic role of HGF has been proposed in the regeneration of osteoarticular tissues. HGF also influences bone remodeling and peripheral nerve activity. Studies aimed at elucidating the changing role of HGF/c-Met signaling in OA and IDD at different pathophysiological stages, and their specific molecular mechanisms are needed. Such studies will contribute to safe and effective HGF/c-Met signaling-based treatments for OA and IDD. 相似文献
2.
Anton Pshenichnikov Saishun Yamazaki David Bottomley Yuji Nagae Masaki Kurata 《Journal of Nuclear Science and Technology》2019,56(5):440-453
In the present paper, new results using in situ video are presented regarding boiling water reactor (BWR) control blade degradation up to 1750 K at the beginning of a nuclear severe accident. Energy-dispersive X-ray spectrometry (EDS) mapping indicated stratification of the absorber blade melt with formation of a chromium and boride-enriched layer. High-content-B- and C-containing material with increased melting temperature acted like a shielding and was found to prevent further relocation of control blade claddings. The interacted layers around the B4C-granules prevented direct steam attack of residual B4C. The results provide new insights for understanding of the absorber blade degradation mechanism under reducing conditions specific to Fukushima Dai-Ichi Unit 2 resulting from prolonged steam starvation. 相似文献
3.
Kosuke Higashida Haruki Nagae Kazushi Mashima 《Advanced Synthesis \u0026amp; Catalysis》2016,358(24):3949-3954
Dinuclear triply chloro‐bridged iridium(III) complexes bearing chiral diphosphine ligands catalyze the asymmetric hydrogenation of tosylamido‐substituted pyrazines to give the corresponding chiral tetrahydropyrazines with an amidine skeleton in high yield and with high enantioselectivity. Addition of N,N‐dimethylanilinium bromide enhanced the catalytic activity of the iridium complexes and also increased the enantioselectivity of the products by trapping the hydrogenated amine products with HBr from N,N‐dimethylanilinium bromide. The amidine skeleton of the products could be transformed to give chiral piperazinones and piperazines without loss of enantioselectivity.
4.
Yusei Maruyama Tsugiko Takase Masateru Yoshida Kensuke Kogure Kenji Suzuki Kazuyuki Tohji 《Fullerenes, Nanotubes and Carbon Nanostructures》2013,21(2):211-221
Abstract Single-walled carbon nanotubes (SWCNT) prepared by a DC-Arc-Discharge and purified by a hydrothermal treatment followed by several steps of procedures including heating, burning, extracting and acid-washing are investigated by a conventional STM technique morphologically and spectroscopically. The electical resistivities of compacted pellets (mats) of SWCNT are measured as a function of temperature in the range from the room-temperature to 1.5K. The behaviors seems to be essentially originated in the metallic nature of individual SWCNT. 相似文献
5.
Masahiro Nagae Tetsuo Yoshio Yoshito Takemoto Jun Takada 《Journal of the American Ceramic Society》2001,84(5):1175-1177
For pure molybdenum nitrided at 1373 K in NH3 gas, microstructural observations of a molybdenum nitride layer were conducted through a transmission electron microscope. The molybdenum nitride layer consisted of two molybdenum nitrides: an outer one of γ-Mo2 N and an inner one of β-Mo2 N. A great number of (011)[0 1] type twins were observed in the β-Mo2 N phase, whereas the microstructure of the γ-Mo2 N phase was almost free from lattice defects except for slightly observed {111}〈112〉 type twin. 相似文献
6.
7.
Hydrogen transfer from donor solvent to coal must involve reactions such as hydrogen donation to free radicals and hydrogenation of aromatic structures. The relative reactivities of five typical hydrogen donor solvents, more reactive than tetralin, were determined using a competing elimination reaction in the liquefaction of a bituminous coal at 400 °C and a brown coal at 350 °C. 9,10-Dihydroanthracene, 9,10-dihydrophenanthrene and 1,2,3,4-tetrahydroquinoline exhibited outstanding hydrogen donating ability. Further, the relative reactivities of five mild hydrogen donor solvents such as acenaphthene and indan were determined by a similar elimination reaction using a bituminous coal at 450 °C. 相似文献
8.
T. Takida M. Mabuchi N. Nakamura T. Igarashi Y. Doi T. Nagae 《Metallurgical and Materials Transactions A》2000,31(3):715-721
The tensile properties of a ZrC particle-dispersed Mo, which was processed by spark plasma sintering with mechanically alloyed
powder, were investigated at room temperature and at elevated temperatures of 1170 to 1970 K. The Mo-ZrC alloy showed much
higher strength at room temperature than a fully recrystallized pure Mo. The high strength of Mo-ZrC is mainly attributed
to a very small grain size (about 3 μm). The main role of the ZrC particle is not to increase strength due to the particle-dislocation interaction, but to limit
grain growth during sintering and to attain the very small grain size. The elongation at room temperature of Mo-ZrC was much
lower than that of pure Mo. This is probably related to the higher interstitial contents. However, Mo-ZrC showed a large elongation
of 180 pct at 1970 K and 6.7×10−4 s−1. It was suggested that the ZrC particles stabilized the fine-grained microstructure yet provided no cavitation sites at 1970
K; as a result, the large elongation was attained. 相似文献
9.
Jorn A. Cheney Jonathan P. J. Stevenson Nicholas E. Durston Masateru Maeda Jialei Song David A. Megson-Smith Shane P. Windsor James R. Usherwood Richard J. Bomphrey 《Journal of the Royal Society Interface》2021,18(180)
In gliding flight, birds morph their wings and tails to control their flight trajectory and speed. Using high-resolution videogrammetry, we reconstructed accurate and detailed three-dimensional geometries of gliding flights for three raptors (barn owl, Tyto alba; tawny owl, Strix aluco, and goshawk, Accipiter gentilis). Wing shapes were highly repeatable and shoulder actuation was a key component of reconfiguring the overall planform and controlling angle of attack. The three birds shared common spanwise patterns of wing twist, an inverse relationship between twist and peak camber, and held their wings depressed below their shoulder in an anhedral configuration. With increased speed, all three birds tended to reduce camber throughout the wing, and their wings bent in a saddle-shape pattern. A number of morphing features suggest that the coordinated movements of the wing and tail support efficient flight, and that the tail may act to modulate wing camber through indirect aeroelastic control. 相似文献
10.
Antioxidant Effects of Herbal Tea Leaves from Yacon (Smallanthus sonchifolius) on Multiple Free Radical and Reducing Power Assays,Especially on Different Superoxide Anion Radical Generation Systems 下载免费PDF全文
Shintaro Sugahara Yuto Ueda Kumiko Fukuhara Yuki Kamamuta Yasushi Matsuda Tatsuro Murata Yasuhiro Kuroda Kiyotaka Kabata Masateru Ono Keiji Igoshi Shin Yasuda 《Journal of food science》2015,80(11):C2420-C2429
Yacon (Smallanthus sonchifolius), a native Andean plant, has been cultivated as a crop and locally used as a traditional folk medicine for the people suffering from diabetes and digestive/renal disorders. However, the medicinal properties of this plant and its processed foods have not been completely established. This study investigates the potent antioxidative effects of herbal tea leaves from yacon in different free radical models and a ferric reducing model. A hot‐water extract exhibited the highest yield of total polyphenol and scavenging effect on 1,1‐diphenyl‐2‐picryl hydrazyl (DPPH) radical among four extracts prepared with hot water, methanol, ethanol, and ethylacetate. In addition, a higher reducing power of the hot‐water extract was similarly demonstrated among these extracts. Varying concentrations of the hot‐water extract resulted in different scavenging activities in four synthetic free radical models: DPPH radical (EC50 28.1 μg/mL), 2,2′‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonic acid) cation radical (EC50 23.7 μg/mL), galvinoxyl radical (EC50 3.06 μg/mL), and chlorpromazine cation radical (EC50 475 μg/mL). The yacon tea‐leaf extract further demonstrated superoxide anion (O2?) radical scavenging effects in the phenazine methosulfate‐NADH‐nitroblue tetrazolium (EC50 64.5 μg/mL) and xanthine oxidase assay systems (EC50 20.7 μg/mL). Subsequently, incubating human neutrophilic cells in the presence of the tea‐leaf extract could suppress the cellular O2? radical generation (IC50 65.7 μg/mL) in a phorbol 12‐myristate 13‐acetate‐activated cell model. These results support yacon tea leaves may be a good source of natural antioxidants for preventing O2? radical‐mediated disorders. 相似文献