特发性肺纤维化急性加重期证候与血清生物标志物的相关性研究＊

目的 通过分析特发性肺纤维化急性加重期（AE-IPF）患者证候与血清生物标志物的关系，为中医辨证治疗提供参考。方法 采用观察性研究设计，收集2019年3月至2019年11月三个中心的AE-IPF患者76例，其中痰热壅肺证26例、痰浊阻肺证50例，并纳入健康志愿者10例作为对照。采用ELISA测定患者血清CCL18、HMGB1、KL-6、MMP-7、SP-A和SP-D水平，分析与中医证候的相关性。结果 AE-IPF患者血清CCL18、HMGB1、KL-6、MMP-7、SP-A和SP-D水平均显著高于健康对照组。血清CCL18、HMGB1、KL-6、MMP-7和SP-D水平在痰热壅肺证和痰浊阻肺证患者间无显著性差异（P＞0.05），而血清SP-A水平存在显著性差异（P＜0.05）。结论 血清SP-A与AE-IPF证候存在一定的相关性，血清SP-A的浓度升高，与痰热壅肺证关系越密切，反之，血清SP-A浓度降低，则与痰浊阻肺证关系越密切。AE-IPF痰热壅肺证患者的预后可能较痰浊阻肺证患者更差。     

国产COSTANT冠状动脉支架治疗重症冠心病的远期疗效观察

目的评价国产COSTANT冠脉支架治疗重症冠心病的安全性和远期疗效。方法回顾性分析2001-03～2003-08沈阳军区总医院和广州省人民医院2个心脏中心应用COSTANT冠脉支架治疗71例重症冠心病者即刻疗效和2年随访结果。结果共置入COSTANT支架86枚，其他支架58枚，手术成功率均为100％。院内主要不良心脏事件（MACE）共3例（其中死亡2例、1例支架内发生亚急性血栓）。69例失访6例（随访率91．3％），63例随访21～26个月中4例死亡，21例行冠脉造影复查（占30．4％），8例发生再狭窄（RS）（COSTANT支架4例，其他支架3例，1例COSTANT和其他支架均RS并死亡），5例出现新生病变。COSTANT支架RS率为7．9％（5／63）、MACE发生率12．7％（8／63）。结论2年的长期随访结果表明国产COSTANT冠状动脉支架可安全用于重症冠心病介入治疗，且长期疗效较好。     

青岛市某高校学生精神药物使用情况调查

本文采用个人自填问卷方式，对青岛市某高校三年级和五年级学生使用包括酒类、香烟在内的精神药物的情况进行调查。结果表明大学生对酒、香烟等精神药物的使用较为普遍。其中烟、酒的使用率随着年级的增长而提高，五年级学生饮酒、抽烟率明显高于三年级学生（Ｐ＜０．０５）。提示大学生中酒、香烟等精神药物的使用问题是值得注意的。     

Expression of CD68 CD45RO CD20 and proliferating cell nuclear antigen in nasal polyps]

OBJECTIVE: To study the cellular expression of CD45RO, CD20, CD68 and proliferating cell nuclear antigen (PCNA) in nasal polyps. METHODS: Nasal polyp tissues from 50 patients were evaluated for cellular expression of CD45RO, CD20, CD68 and PCNA using immunohistochemistry SP by counting the average number in 5 chosen high-power fields, Histopathological observations were combined with HE. Analyses were performed on SPSS10.0. RESULTS: CD68+ cells were expressed more in nasal polyps dominated by eosinophils than by neutrophils(P < 0.05). There was no difference between CD45RO and CD20, but both of them had negative correlation(P = 0.05). Significant correlation was found between CD68+ cells and eosinophils or PCNA positive cells on epithelium. PCNA positive cells on epithelium had significant correlation on fibroblast (P < 0.05). CONCLUSION: Inflammatory cell infiltration (eosinophilia CD45RO, CD20, CD68) and cell proliferating in epithelium cells, glandular cell and fibroblast are strongly correlated with formation of nasal polyps. The nasal polyps are not only characteristic of eosinophilia but also by lymphocytes dominated by CD45RO and CD68 positive cells. CD68 may be stem cell of nasal polyp.     

高原地区人胎儿脊柱的生长发育

本文用X线摄片的方法,对西宁地区胎龄为17—36周的60例胎儿脊柱的骨化及生长动态进行了研究。结果:1、提供了高原地区人胎儿脊柱长轴生长发育的资料。脊柱各段以胸段为最长,其次为腰、颈、骶段。2、计算出胎龄与脊柱各段长度间的回归方程,据此可以胎龄推算脊柱的长度,反之亦可以脊柱的长度估计胎龄。3、报道了颈、骶、尾段亿发骨化点出现顺序的规律。     

Changes in height of choroidal melanomas after plaque therapy.

Serial ultrasonic measurements of 82 uveal melanomas treated with brachytherapy plaques (cobalt-60 and iodine-125) and followed up for up to 141 months revealed that no two patients had identical patterns of change. The mean absolute change in tumour height after treatment was 1.8 mm at six months, 5.6 mm at 48 months for large tumours, and 0.9 and 1.9 mm for medium sized tumours. Eighty of the 82 patients fell into one of three patterns of response: 57 patients had a decrease in height after treatment (type D), 13 patients had the same height after treatment (type S), and 10 patients had a progressive increase in height (type I). Life table comparison showed no correlation between survival and location of tumour, sex of patient, size of tumour when treated, or laterality. There was a slight correlation between age and survival. Patients older than 60 died more frequently from metastatic melanoma than those under 60 (p = 0.06). Life table analysis showed a significant correlation between tumour regression type and survival. At 48 months the best cumulative probability of survival was in patients with type D (88% alive) compared with those of type I (34% alive, p = 0.0004).     

兔自体神经原位移植限制创伤性神经瘤形成机理

本实验采用家兔近端正中神经和尺神经原位移植法研究预防创伤性神经瘤形成之机理。经光镜,透射电镜及免疫组化标记观察表明:(1)自体神经原位移植法能有效地抑制创伤性神经瘤形成。两神经再生的神经纤维在移植段中排列整齐,来自两神经的轴索末端髓鞘对接是抑制创伤性神经瘤形成的关键;(2)移植段中由于雪旺氏细胞增生所形成的雪旺氏鞘对近端神经轴索的再生有趋化和引导作用;(3)单纯吻合法不能抑制创伤性神经瘤的发生。     

去甲肾上腺素缩血管作用对犬冠状血管舒张的限制

在10只麻醉开胸犬的左前降支冠状动脉(LAD)恒流灌注,持续监测灌注压,并于冠脉内注入2.5mg心得宁以阻断心脏的β_1-肾上腺素能受体,观察去甲肾上腺素(NE,α-肾上腺素能刺激)对LAD内给予腺苷所致冠状血管舒张的限制作用。随着LAD内注入的腺苷量增加,冠状动脉阻力(R)咸剂量依赖性降低,分别为对照值的8.7％(2μg/min),20.6％(10μg/min)和28％(50μg/min)。而于LAD内再给予相同齐0量(6μg)的NE,则使不同剂量扩张的冠脉收缩,R成阶梯状增加,分别为对照值的17.4％(腺苷2μg/ml),23.2％(腺苷10μg/min)和34.1％(腺苷50μg/min),表现为隙苷引起的冠状血管扩张愈大,NE能刺激引起的缩血管作用愈强。这表明α-肾上腺素能缩血管作用可限制腺苷引起的冠状血管舒张,因而有助于保持冠状血管张力及其储备力。     

玻璃体切除术联合睫状体平部切口摘除球内异物

报道玻璃体切除术联合睫状体平部切口摘除球内异物的联合手术，治疗眼球后段异物８例８眼。其中，３眼为非磁性异物，５眼为磁性异物，均一次手术成功取出异物。介绍了此联合手术的方法，并对其意义、适应证以及手术前的准备进行了较为详细的讨论，对其并发症的处理和预防也作了叙述。