益母草的化学、药理和临床研究进展

查阅近20年有关文献，对益母草的化学成分、药理作用、临床应用研究进展进行综述。益母草主要含有生物碱类、黄酮类、二萜类、脂肪酸类、挥发油类等化合物；药理作用研究证明其具有调经止血、保护心肌缺血再灌注损伤、抗血小板聚集、降低血液黏度等作用；在临床上常用来治疗流产后出血、冠心病、心肌缺血、高黏血症、痛经等疾病。益母草具有广泛的药理活性，对其药效学物质基础进行深入研究和开发，将具有重要意义。     

Inhibitory effect of diosgenin on experimentally induced benign prostatic hyperplasia in rats

This study investigated the effect of diosgenin, a natural sapogenin possessing various pharmacological activities, on benign prostatic hyperplasia (BPH) in rats and the possible mechanisms. BPH was established in the castrated rats by subcutaneous injection of testosterone propionate. Animals were randomly divided into four groups (n=10 each): model group (0.5% sodium carboxymethyl cellulose); positive control group (3 mg/kg finasteride); two diosgenin groups (50 and 100 mg/kg). The drugs were intragastricaly given in each group for consecutive 3 weeks. Another 10 rats with no testicles cut off served as negative controls and they were subcutaneously injected with 0.1 mL olive oil per day and then treated with 0.5% sodium carboxymethylcellulose. After 3-week administration, the prostate index and serum PSA level were determined, and histopathological examination was carried out. The levels of MDA, SOD and GPx in prostates were also measured. Additionally, the expression of Bcl-2, Bax and p53 was examined using Western blotting. The results showed that the prostate index and serum PSA level were significantly decreased, and the pathological changes of the prostate gland were greatly improved in diosgenin groups as compared with the model group. Elevated activities of SOD and GPx, and reduced MDA level were also observed in diosgenin-treated rats. In addition, the expression of Bcl-2 in prostates was down-regulated, whereas that of Bax and p53 was up-regulated in diosgenin-treated rats. These results indicated that diosgenin was effective in inhibiting testosterone propionate-induced prostate enlargement and may be a candidate agent for the treatment of BPH.     

试论微米中药

本文作者首次提出微米中药的概念,阐述了微米中药的特点、优势及其应用前景,分析了开发微米中药的技术难点及其对策,并指出微米中药的研制与生产将为中药现代化和中药科技产业化开辟新领域。     

三白脂素-8的抗炎作用

三白草木脂素类化合物三白脂素－8（Saucemetilignan-8)对角叉菜胶所致的大鼠急性炎症和棉球肉芽肿,均具有明显地抗炎活性。     

赤芍化学成分和药理作用的研究进展

赤芍含有丰富的苷类化合物。药理作用研究证明其具有抑制血小板和红细胞聚集、抗凝和抗血栓、抗动脉粥样硬化、保护心脏和肝脏、抗肿瘤等作用 ,具有广泛的药理活性。对其与药理作用相关的药效学物质基础进行深入地研究和开发 ,具有重要意义     

香附的研究进展

香附为双子叶植物莎草科植物莎草(Cyperus rotundus L.)的干燥根茎,别名莎草根、香附子、香附米等,性平,味辛微苦,入肝、三焦二经,功能调经止痛、疏肝理气,常用于肝郁气滞,胸、胁、脘腹胀痛,月经不调等症.印度民间用于发热、痢疾、荨麻疹、疼痛等疾病[1].该中药在我国民间广泛应用,现已被开发成制剂投入市场,本文综述了近年来国内外对香附药化、药理、临床应用等多方面的研究情况,为该植物的进一步开发研究提供参考.     

指纹图谱技术在中药研究中的应用

综述各种指纹图谱的特点以及各自的发展现状,简要阐述国内外天然药物和中药研究应用指纹图谱的情况,介绍关于计算机辨识技术在中药指纹图谱上的发展以及中药指纹图谱在中药生产及科研领域的发展前景.     

HPLC法测定宫廷补酒中丹参酮ⅡA的含量

目的：建立宫廷补酒中丹参酮ⅡA的含量测定方法。方法：C19柱，甲醇-水(90：10)为流动相，流速为lmL／min，UV检测波长为270nm。结果：此方法线性关系良好，平均加样回收率为102．99％，(n=5)。结论：本法结果准确可靠，为控制宫廷补酒的质量提供了依据。     

小儿化痰止咳颗粒质量标准研究

目的制定小儿化痰止咳颗粒质量标准。方法采用薄层色谱法对处方中的麻黄碱、吐根、桔梗进行定性鉴别；采用高效液相色谱法对盐酸麻黄碱进行含量测定。结果样品浓度在0.04～0.20 μg·mL^-1范围内，浓度与峰面积比有良好的线性关系，重现性RSD＝0.71%，稳定性RSD＝0.66%，平均加样回收率为99.44% (n＝6)。结论该方法简单、快速、准确，可作为小儿化痰止咳颗粒的质量控制方法。