中西医结合治疗功能性消化不良临床观察

目的评价中西医结合治疗脾虚气滞型功能性消化不良的临床疗效。方法将112例中医辨证为脾虚气滞型的功能性消化不良患者随机分为治疗组和对照组。对照组给予西医规范治疗,治疗组在对照组基础上加用中药治疗。两组疗程均为3周。观察两组患者的症状、体征、疗效。结果治疗后两组患者对比,治疗组患者的症状改善较对照组更为明显。其差异具有统计学意义(P0.05)。结论中医药能更好地改善功能性消化不良患者的临床症状,较单纯西医治疗更能获得满意的疗效。     

益智逐瘀颗粒治疗血管性痴呆48例

目的观察益智逐瘀颗粒治疗痰血瘀阻型血管性痴呆的临床疗效。方法将96例血管性痴呆患者随机分为两组,对照组48例给予西药单唾液酸四己糖神经节苷脂钠治疗,治疗组48例在西药单唾液酸四己糖神经节苷脂钠治疗的基础上加服益智逐瘀颗粒,10d为一个疗程,两组均连续治疗2个疗程后判定疗效。结果治疗组总有效率为91.67%,对照组总有效率为64.58%,两组疗效比较,差异有显著性(P0.05)。结论益智逐瘀颗粒治疗痰血瘀阻型血管性痴呆疗效显著。     

中西医结合长疗程治疗强直性脊柱炎临床分析

目的探讨在强直性脊柱炎临床治疗中运用中西医结合方法的临床效果。方法选取我院2013—2016年收治的90例强直性脊柱炎患者作为本次研究对象,按照治疗方式不同将所选病例分为采取中西医结合治疗的观察组与单纯运用西医治疗的对照组,比较两组治疗效果。结果观察组本次治疗总有效率明显高于对照组,差异有统计学意义(P0.05);治疗后两组患者ESR、CRP均有不同程度地降低,但观察组上述两项指标降低的程度显著优于对照组,差异有统计学意义(P0.05)。结论在强直性脊柱炎临床治疗中采取中西医结合治疗临床效果显著,明显降低患者ESR、CRP指标,值得临床推广应用。     

腮腺复发性多形性腺瘤的临床分析--附22例报告

目的：探讨腮腺多形性腺瘤复发、恶变的原因及临床治疗方法。方法：对22例腮腺多形性腺瘤复发患者进行回顾性分析和追踪调查。结果：多数腮腺多形性腺瘤复发病例肿块呈多灶性（18／22），手术越简单其复发率越高，复发间期越短（P＜0．05）。22人中有7例发生恶变，占31．8％，恶变与初发年龄较大有关（P＜0．05），与手术次数关系不大。末次手术分别采用浅叶切除术，腮腺全切术、扩大切除术，对7例有恶变者于术后辅以放射治疗。术后平均追踪54月，除1例多形性腺瘤恶变者于术后30月时肿瘤复发外，其余均未见复发。结论：不恰当的手术方式是导致腮腺性多形性腺瘤复发的直接原因。     

Biodistribution of a carborane-containing porphyrin as a targeting agent for Boron Neutron Capture Therapy of oral cancer in the hamster cheek pouch

Boron Neutron Capture Therapy (BNCT) is a bimodal cancer treatment based on the selective accumulation of 10B in tumors and concurrent irradiation with thermalized neutrons. The short-range, high-LET radiation produced by the capture of neutrons by 10B could potentially control tumor while sparing normal tissue if the boron compound targets tumor selectively within the treatment volume. In previous studies, we proposed and validated the hamster cheek pouch model of oral cancer for BNCT studies, proved that absolute and relative uptake of the clinically employed boron compound boronophenylalanine (BPA) would be potentially therapeutic in this model and provided evidence of the efficacy of in vivo BPA-mediated BNCT to control hamster oral mucosa tumors with virtually no damage to normal tissue. We herein present the biodistribution and pharmacokinetics of a lipophilic, carborane-containing tetraphenylporphyrin (CuTCPH) in the hamster oral cancer model. CuTCPH is a novel, non-toxic compound that may be advantageous in terms of selective and absolute delivery of boron to tumor tissues. For potentially effective BNCT, tumor boron concentrations from a new agent should be greater than 30 ppm and tumor/blood and tumor/normal tissue boron concentration ratios should be greater than 5/1 without causing significant toxicity. We administered CuTCPH intraperitoneally (i.p.) as a single dose of 32 microg/g body weight (b.w.) (10 microg B/g b.w.) or as four doses of 32 microg/g b.w. over 2 days. Blood (Bl) and tissues were sampled at 3, 6, 12, 24, 48, and 72 h in the single-dose protocol and at 1-4 days after the last injection in the multidose protocol. The tissues sampled were tumor (T), precancerous tissue surrounding tumor, normal pouch (N), skin, tongue, cheek and palate mucosa, liver, spleen, parotid gland and brain. The maximum mean B ratios for the single-dose protocol were T/N: 9.2/1 (12h) and T/Bl: 18.1/1 (72 h). The B value peaked to 20.7+/-18.5 ppm in tumor at 24h. The multidose protocol maximum mean ratios were T/N: 11.9/1 (3 days) and T/Bl: 235/1 (4 days). Absolute boron concentration in tumor reached a maximum value of 116 ppm and a mean value of 71.5+/-48.3 ppm at 3 days. The fact that absolute and relative B values markedly exceeded the BNCT therapeutic threshold with no apparent toxicity may confer on this compound a therapeutic advantage. CuTCPH-mediated BNCT would be potentially useful for the treatment of oral cancer in an experimental model.     

氦-氖激光和深海鱼油联合治疗复发性口腔溃疡的疗效评价

目的 观察氦-氖激光和深海鱼油联合治疗复发性口腔溃疡(RAU)的临床效果。方法 将159名复发性口腔溃疡病人随机分成3组。联合治疗组(以下称联合组):用氦-氖激光局部照射和口服深海鱼油联合治疗;对照1:仅用氦-氖激光局部照射溃疡;对照2:每日早晚各口服深海鱼油1000mg。结果(1)有效率:联合组:88.68％,对照组1:73.59％,对照组2:66.04%。联合组与对照组1或对照组2均有显著的差异(x_1~2=3.95,P<0.05,x~_2=7.76,P<0.05)。(2)平均溃疡期:联合组(4.15±1.36)d,对照组1(4.55±1.41)d,对照组2(6.36±1.44)d,联合组与对照组1或对照组2均有显著的差异(t_1=2.19,P<0.05;t_2=2.35,P<0.05)。(3)疼痛指数:联合组(2.85±1.32),对照组1(3.45±1.49),对照组2(5.66±1.69),联合组与对照组1或对照组2均有显著的差异(t_1=3.07,P<0.01;t_2=2.98,P<0.01)。结论氦-氖激光和深海鱼油联合治疗复发性口腔溃疡取得了较满意的临床效果。     

口腔白色念珠菌病95 例临床分析及治疗体会

目的：探讨口腔白色念珠菌病的发病原因，提出初步治疗和预防措施。方法：对95例口腔白色念珠菌患者进行分型，并采用氟康唑、多抗甲素等药物对各型口腔念珠菌病患者进行综合治疗，观察其疗效；同时进行真菌学学涂片镜检，了解所用药物对白色念珠菌的清除情况。结果：综合治疗后，白色念珠菌病患者治愈率为35．79％，好转率为57．89％；白色珠菌清除率为80．59％。结论：白色念珠菌为条件致病菌，在全身或局部因素诱导下容易发病，氟康唑等药物能有效治疗口腔白色念珠菌病。     

颈动脉体瘤的诊断和治疗

目的:探讨颈动脉体瘤的诊治经验,提高诊断准确率和手术成功率,降低并发症发生率。方法:回顾分析1996~2005年收治的30例颈动脉体瘤患者的临床资料。结果:30例患者均行DSA检查,均诊断为颈动脉体瘤;B超检查14例,12例诊断为颈动脉体瘤;CT检查20例,16例诊断为颈动脉体瘤;MR I/MRA检查16例,14例诊断为颈动脉体瘤。22例患者行TBO检查,8例为阳性。30例患者均行手术治疗,29例患者预后良好,1例发生永久性偏瘫,随诊期间无肿瘤复发。结论:DSA检查是诊断颈动脉体瘤的最佳方法,而MR I/MRA和BUS检查在颈动脉体瘤的诊断中具有重要价值。手术切除是治疗颈动脉体瘤的首选治疗措施。DSA和TBO同时检查,能为制定手术方案提供重要参考。应做好充分的术前准备,术前常规行M atas训练。术中精细的解剖可以降低术后并发症的发生。     

A comparison of two scar massage protocols in pediatric burn survivors

The current evidence to support the use of massage for scar management is conflicting in the literature. The purpose of this study was to compare two scar massage protocols administered with pediatric burn survivors to determine if a more structured and standardized approach to scar massage could improve outcome. A retrospective review of the medical records of 100 children who received massage during the time period when two different protocols were implemented was conducted and data that was collected as part of the clinical exam regarding scar height, vascularity, pliability, itch and pain were extracted. Comparisons were made within subject for scar changes from baseline to follow up and between subjects receiving Protocol A and those receiving Protocol B for the same scar characteristics. Versions of the Vancouver Scar Scale were used to assess scars, while visual analogue scale, Itch Man Scale and Wong-Baker Faces Pain Scale were used to assess itch and pain. Results demonstrated improvements in itch and vascularity over time with both scar massage protocols. However, when comparing patients who received Protocol A to those who received Protocol B, there was no difference found in scar height, vascularity, pliability, itch or pain. Using commonly applied subjective scar assessment tools, we did not find clinically meaningful changes in scar characteristics with the implementation of a structured scar massage program compared to a general approach to massage. Further research is needed to better define the impact of massage on the recovery experience for burn survivors.     

下肢力线在盘状半月板损伤应用的研究进展

盘状半月板损伤是一种常见的运动损伤,其治疗方法有在关节镜下行盘状半月板成形术、盘状半月板次全切术、盘状半月板全切术等,虽术后短期临床效果佳,但远期临床效果不理想。目前对于盘状半月板损伤手术方式的选择,不同的学者有不同的观点。近年来众多学者研究表明术式的选择及术后下肢力线的改变与盘状半月板损伤的治疗效果相关。本文主要总结了盘状半月板损伤的治疗现状及术后下肢力线的变化情况,阐述了下肢力线的评估在盘状半月板治疗中的作用,为临床个体化治疗盘状半月板损伤提供依据。