中国汉族正常成人视束的高分辨率MRI测量

Objective To explore the morphological characteristics of optic tracts in healthy Chinese Han adults on the high-resolution MRI and fill the database of Chinese standard brain with morphological data of optic tracts.Methods Cerebral MRI scans with T1 WI 3D MPRAGE sequence of 1000 healthy Chinese volunteers from 15 hospitals were divided into five stages, ranging in age from 18 to 70.With the technique of multi-baseline, structure and morphology of optic tracts were displayed optimally on the images with multiplanar reconstruction.Data were measured as following: transverse distance of the cisternal optic tract (TD1) and peri-crural optic tract (TD2), length from the cisternal optic tract to the peri-crural optic tract (L) ,angle between optic tract(AOT) and height of optic tract from its first segment to plane of anterior commissure (H) including H1, H2, H3, H4 and HS.The measurements of optic tracts between sexualities and among age groups were compared by anasis of covariance; those among five age groups were compared pairwisedly by least significant difference analysis (LSD); and the differences of measurements between left and right optic tracts were analyzed using paired t test.Results (1) Comparisons of optic tract structures between male and female: the mean optic tract length of male [(11.69±1.45),(11.56±1.44) mm] was significant longer than that of female [(10.58±1.29),(10.40±1.34) mm] (F=22.236, 29.703, P=0.000); the mean H1 of male [(2.56±0.28),(2.60±0.29) mm] and female [(2.57±0.31 ), (2.63±0.32) mm] were significantly different ( F =11.130,7.805, P = 0.000, 0.005).No significant differences of the other measurements were found between male and female ( P > 0.05 ).(2) Comparisons among age groups: among 5 age groups, TD1 of both sides [left TD1 :(4.64±0.51 ), (4.64±0.57), (4.55±0.58), (4.39±0.53), (4.36±0.58)mm;right TD1 :(4.84±0.53) ,(4.80±0.60), (4.77±0.65), (4.60±0.59), (4.57±0.59) mm] and the right TD2[(3.33±0.45),(3.34±0.41),(3.33±0.36),(3.23±0.38),(3.23±0.39) mm] had statistical differences ( F = 3.458, 2.735, 4.711, P = 0.008,0.028, 0.001 ).The LSD analysis found that the 50 years old group was the watershed with significant differences ( P < 0.05 ).The results also showed that the L of both sides had statistical differences among 5 age groups ( F = 14.510,14.532, P = 0.000).The LSD analysis found that the 60 years old group was the watershed with significant differences (P <0.05).Left TD2 and the H1-H5 of both sides had no significant differences among age groups ( P >0.05).(3) Comparisons of the measurements between left and right optic tracts: TD1 of bilateral optic tracts were (4.52±0.57)and(4.72±0.60) mm respectively; H1 of bilateral optic tracts were (2.56±0.30)and (2.61±0.30) mm respectively; H2 of bilateral optic tracts were (2.66±0.30)and (2.70±0.30) mm respectively; and L of bilateral optic tracts were ( 11.14±1.47 ) and ( 10.98±1.50 )mm respectively.There were significant differences in these measurements between left and right optic tracts( t =12.460, - 6.013,5.595,4.784, P = 0.000 ), while there were no significant differences in TD2, H3, H4 and H5( P > 0.05 ).Conclusions With high-resolution MR1 and 3D reconstruction, optic tract can be displayed clearly and measured accurately.There are definite differences in anterior segments of optic tracts between sexualities, sides and among ages in normal Chinese Han adults, while the posterior segments of optic tracts keep stable.Normal reference values of optic tracts in Chinese Han adults are provided to clinical practices and scientific researches, which are valuable for building of Chinese standard brain.     

中国汉族正常成人岛叶体积的高分辨率MRI测量

目的 测量中国正常汉族成人岛叶体积,分析岛叶体积与年龄、性别、体重及颅脑容积的相关性,为建立中国标准脑提供可靠数据.方法 选择健康汉族成人志愿者1000名,按照年龄18～30、31～40、41～50、51～60、61～70岁分为A、B、C、D、E组,每组男、女各100名.所有受试者均行3D磁化强度预备梯度回波序列T1WI,应用3D体积分析软件手工勾绘ROI,测最健康中国成年人岛叶的体积,并进行标准化处理.双侧岛叶体积间比较采用配对t检验分析,不同性别间岛叶体积比较用两独立样本t检验分析,不同年龄段之间进行单因素方差分析.结果 标准化前1000名受试者左、右侧岛叶体积分别为(7764±1165)、(7387±1128)mm3,标准化后为(8413±1201)、(7871±1140)mm3,左侧大于右侧(t值分别为-10.565、-16.014,P值均<0.01).标准化前男性左、右侧岛叶体积分别为(8146±1181)、(7735±1113)mm3,女性左、右侧岛叶体积分别为(7393±1022)、(7050±1038)mm3,男性左、右侧岛叶体积均大于女性(t值分别为10.934、9.945,P值均<0.01).标准化后男性左、右侧岛叶体积分别为(8779±1230)、(8224±1081)mm3,女性左、右侧岛叶体积分别为(8043±1054)、(7515±1091)mm3,男性左、右侧岛叶体积均大于女性(t值分别为4.858、4.632,P值均<0.01).标准化前A、B、C、D、E组左侧岛叶体积分别为(8268±1221)、(8067±1107)、(7869±1109)、(7603±1111)、(6997±934)mm3,右侧岛叶体积分别为(8028±1156)、(7636±1075)、(7294±986)、(7249±1068)、(6717±916)mm3,5组间左、右侧岛叶体积差异均有统计学意义(F值分别为-0.361、-0.337,P值均<0.01).标准化后A、B、C、D、E组左侧岛叶体积分别为(9093±1105)、(8679±965)、(8810±1136)、(8202±980)、(7273±940)mm3,右侧岛叶体积分别为(8694±1005)、(8136±1100)、(8034±910)、(7496±990)、(6989±932)mm3,5组间左、右侧岛叶体积差异均有统计学意义(F值分别为-0.490、-0.512,P值均<0.01).岛叶体积与年龄的相关性分析:标准化前、后,左、右侧岛叶体积与年龄之间均呈负相关(标准化前:r值分别为-0.361、-0.337,标准化后r值分别为-0.490、-0.512,P值均<0.05).标准化前左、右侧岛叶体积与颅脑容积之间均呈正相关(r值分别为0.470、0.459,P值均<0.05).标准化前左、右侧岛叶体积与体重之间均呈正相关,(r值分别为0.141、0.092,p值均<0.05).结论 1.5 T MR扫描仪分辨率高,能清晰显示脑内灰白质,能明确辨别岛叶的边界,为岛叶体积测量提供依据,为正常成人岛叶体积建立提供科学数据.     

两种测量软件在杏仁核体积测量中的比较

目的 对比分析Midob(Mi)与Aquariusws(Aq)测量软件在MR图像上测量杏仁核体积的应用.方法 在T1加权三维磁化强度预备梯度回波序列大脑MR图像上,用Mi和Aq测量软件分别测量31名健康成年人双侧杏仁核的体积,并对体积指标进行标准化处理.结果 高分辨率MR三维图像应用不同的测量软件能分辨杏仁核界限,两种测量软件所得杏仁核体积差异无统计学意义(t=0.77,P>0.05).结论 Mi和Aq测量软件对杏仁核体积测量一致性高,适于临床推广应用.     

中国汉族正常成人垂体的高分辨率MRI研究

Objective To study the morphological characteristics of pituitary glands in healthy adult of the Han nationality on the High-resolution MRI and provide morphological data of pituitary glands for the construction of database for Chinese Standard Brain.Methods This is a clinical multi-center study.Nine hundred and seventy eight Chinese healthy volunteers (age range = 18 to 70) recruited from 16 hospitals were divided into 5 groups, i.e., Group A ( age range = 18 to 30), B ( age range = 31 to 40), C ( age range = 41 to 50), D ( age range = 51 to 60 ), and E ( age range = 61 to 70).All of the volunteers were scanned by MR using T, weighted three-dimensional magnetization prepared rapid acquisition gradient echo sequence.By Multiplan reconstruction with 3D software, the pituitary gland's volume, size, and inclination of pituitary stalk were measured and the differences between sexualities and among age groups were compared by analysis of variance using SPSS13.0; those among five age groups were compared pair-wised by Tukey analysis; and the differences between male and female were analyzed by independent t test, and the differences of measurements of typing of pituitary glands were analyzed by Chi-square analysis.Results( 1 ) Volume of pituitary glands: the mean volume of male and female among 5 age groups were ( 1142±290), (996±223), (979 ±178), (971 ±174), (930 ±189) and (1247 ±210), (1199 ±216),( 1108 ± 196), ( 1059 ± 212 ), (984 ± 177 ) mm3 respectively.There were significant differences among the age groups(F = 13.811,27.091 ,P <0.01), the volume tended to decrease after 30 years old in male and 40 years old in female.Female has bigger volume than man in the same age group (P < 0.05).There were statistically correlation between sexes, age, typing, heights in middle sagittal width in coronal MR and anteroposterior diameter in middle sagittal MR.(2) The size of pituitary giands:the mean heights on middle sagittal MR images of male and female among 5 age groups were(6.6±1.5), (6.0±1.4), (5.6±1.1 ),(5.0±1.2), (4.9±1.4)and (7.9±1.6), (6.4±2.0), (5.6±1.7), (5.1±1.7), (4.4±1.4)mm respectively.There were significant difference among the age groups ( F = 24.582,62.978, P < 0.01 ).Females demonstrated larger pituitary glands than men in the age from 18 to 30 year old groups ( P < 0.01 ).The pituitary height tended to decline after 30 years old, minimum after 50 years old group in male and 40 years old in female.The heights were statistically correlated with sexes and age.The mean width in coronal MR images of male and female among 5 age groups were( 14.8± 1.8), ( 14.7 ± 1.4), ( 14.2±1.9), (14.3 ±2.1), (13.8 ±2.4) and (14.9±1.8), (15.8±1.7), (15.5±2.1), (15.6±2.2),( 14.9±2.1 ) mm respectively.There were significant difference among the age groups( F = 4.566,4.233,P<0.05),The width of pituitary before 30 years old and after 60 years old were smaller than the other groups (P <0.05 ), but man did not show this relationship.The widths were statistically correlation with sexes, age and weight.The mean anteroposterior diameter in middle sagittal images of male and female among 5 age groups were (11.2±1.2), (11.8±1.3), (11.8±1.5), (12.3±1.8), (12.2±2.0) and (11.9±1.3), (12.5±1.5), (12.4±1.5), (12.9±1.6), (12.7±1.6)mm respectively.There were significant difference among the age groups ( F = 7.270, 5.903, P < 0.01 ).Before 60 year old, the anteroposterior diameter was smaller in male than all female groups (P < 0.05 ), and there was a tendency to grow downwards with age.The anteroposterior diameter was statistically correlated with sexes and age.(3)The angle of inclination of pituitary stalks: on reconstructed coronal MRI imaging, the angle of inclination of pituitary stalk were in the middle, no significant differences in the angle measurements were found between male and female among 5 age groups ( P > 0.05).(4) The typing of pituitary glands in middle sagittal MR images : there were significant differences between each typing ( χ2 = 44.212, 107.518, P < 0.01 ), there was a tendency of pituitary upper border to depressed when age increased.Conclusions With highresolution MRI and 3D volumetric analytic software, volume and size of pituitary glands and the angle of inclination of pituitary stalks were accurately measured, and that provide morphological data of pituitary glands for the construction of database for Chinese Standard Brain.     

中国汉族正常成人视束的高分辨率MRI测量

Objective To explore the morphological characteristics of optic tracts in healthy Chinese Han adults on the high-resolution MRI and fill the database of Chinese standard brain with morphological data of optic tracts.Methods Cerebral MRI scans with T1 WI 3D MPRAGE sequence of 1000 healthy Chinese volunteers from 15 hospitals were divided into five stages, ranging in age from 18 to 70.With the technique of multi-baseline, structure and morphology of optic tracts were displayed optimally on the images with multiplanar reconstruction.Data were measured as following: transverse distance of the cisternal optic tract (TD1) and peri-crural optic tract (TD2), length from the cisternal optic tract to the peri-crural optic tract (L) ,angle between optic tract(AOT) and height of optic tract from its first segment to plane of anterior commissure (H) including H1, H2, H3, H4 and HS.The measurements of optic tracts between sexualities and among age groups were compared by anasis of covariance; those among five age groups were compared pairwisedly by least significant difference analysis (LSD); and the differences of measurements between left and right optic tracts were analyzed using paired t test.Results (1) Comparisons of optic tract structures between male and female: the mean optic tract length of male [(11.69±1.45),(11.56±1.44) mm] was significant longer than that of female [(10.58±1.29),(10.40±1.34) mm] (F=22.236, 29.703, P=0.000); the mean H1 of male [(2.56±0.28),(2.60±0.29) mm] and female [(2.57±0.31 ), (2.63±0.32) mm] were significantly different ( F =11.130,7.805, P = 0.000, 0.005).No significant differences of the other measurements were found between male and female ( P > 0.05 ).(2) Comparisons among age groups: among 5 age groups, TD1 of both sides [left TD1 :(4.64±0.51 ), (4.64±0.57), (4.55±0.58), (4.39±0.53), (4.36±0.58)mm;right TD1 :(4.84±0.53) ,(4.80±0.60), (4.77±0.65), (4.60±0.59), (4.57±0.59) mm] and the right TD2[(3.33±0.45),(3.34±0.41),(3.33±0.36),(3.23±0.38),(3.23±0.39) mm] had statistical differences ( F = 3.458, 2.735, 4.711, P = 0.008,0.028, 0.001 ).The LSD analysis found that the 50 years old group was the watershed with significant differences ( P < 0.05 ).The results also showed that the L of both sides had statistical differences among 5 age groups ( F = 14.510,14.532, P = 0.000).The LSD analysis found that the 60 years old group was the watershed with significant differences (P <0.05).Left TD2 and the H1-H5 of both sides had no significant differences among age groups ( P >0.05).(3) Comparisons of the measurements between left and right optic tracts: TD1 of bilateral optic tracts were (4.52±0.57)and(4.72±0.60) mm respectively; H1 of bilateral optic tracts were (2.56±0.30)and (2.61±0.30) mm respectively; H2 of bilateral optic tracts were (2.66±0.30)and (2.70±0.30) mm respectively; and L of bilateral optic tracts were ( 11.14±1.47 ) and ( 10.98±1.50 )mm respectively.There were significant differences in these measurements between left and right optic tracts( t =12.460, - 6.013,5.595,4.784, P = 0.000 ), while there were no significant differences in TD2, H3, H4 and H5( P > 0.05 ).Conclusions With high-resolution MR1 and 3D reconstruction, optic tract can be displayed clearly and measured accurately.There are definite differences in anterior segments of optic tracts between sexualities, sides and among ages in normal Chinese Han adults, while the posterior segments of optic tracts keep stable.Normal reference values of optic tracts in Chinese Han adults are provided to clinical practices and scientific researches, which are valuable for building of Chinese standard brain.     

基于高分辨率MRI的正常中国成人杏仁核体积测量

目的 应用高分辨率磁共振和三维体积分析软件(Aquariusws)测量中国正常成人杏仁核的体积.方法 对43例健康成年中国人行大脑T1加权三维磁化强度预备梯度回波序列扫描,应用Aquariusws软件确定和测量杏仁核边界和体积.结果 经Aquariusws软件对高分辨率MRI图像进行三维重建后,能清楚显示杏仁核的边界.杏仁核平均体积:右侧1596.525 mm3 (男1566.773 mm3女1604.877 mm3),左侧1564.318 mm3(男1623.987 mm3,女1545.244 mm3).双侧、男女杏仁核体积无统计学差异(P>0.05).结论 基于高分辨率磁共振图像和三维体积分析软件(Aquariusws)可以动态三维确认杏仁核轮廓,进而准确测定其体积.     

高分辨力MRI测量中国汉族正常成人豆状核

目的测量中国汉族正常成人豆状核体积,为建立中国成人数字标准脑提供基础数据。方法采用多中心临床研究形式,选取18~80岁健康志愿者1000名,按照年龄18~30、31~40、41~50、51~60、61~80岁进行分组,每组男、女各100名。采用三维磁化强度预备梯度回波T1 W序列扫描获取图像,应用三维体积分析软件手工勾绘ROI,测量豆状核的体积,探讨豆状核体积与年龄的相关关系。结果 1000名正常成人左、右侧壳核体积分别为(4811.59±588.99)mm3和(4763.11±587.59)mm3,左侧壳核体积大于右侧(t=10.134,P<0.0001);左、右侧苍白球体积分别为(1591.31±226.81)mm3、(1627.28±235.06)mm3,左侧苍白球体积小于右侧(t=-9.877,P<0.0001)。男性左、右侧壳核体积和苍白球体积分别为(4962.72±598.49)mm3、(4909.83±600.54)mm3、(1623.24±234.16)mm3和(1663.18±243.56)mm3;女性左、右侧壳核及苍白球体积分别为(4663.65±540.49)mm3、(4619.28±537.59)mm3、(1560.00±215.04)mm3、(1592.09±221.06)mm3,男性体积均大于女性(P均<0.0001)。左、右侧壳核及左、右侧苍白球体积均随年龄增长而减低。结论正常成人豆状核中,壳核体积左侧大于右侧,苍白球体积右侧大于左侧;男性豆状核体积大于女性。豆状核体积均随年龄增大而减小。     

中国汉族正常成人内囊体积的高分辨率MRI测量

目的 测量中国正常汉族成人内囊体积,分析内囊体积与年龄、体质量及颅脑容积的相关性.方法 选择健康汉族成人志愿者1000名,按照年龄18 ～ 30、31～40、41 ～ 50、51 ～ 60、61～80岁分为5组,每组男、女各100名.所有受试者均行3D磁化强度预备梯度回波序列T1WI,应用3D体积分析软件手工勾绘ROI,测量受试者内囊体积,并进行标准化处理.双侧内囊体积间比较采用配对t检验分析,不同性别间内囊体积比较用两独立样本t检验分析,不同年龄段之间内囊体积的比较采用单因素方差分析,并对内囊体积和年龄、体质量、颅脑容积的相关性做积差相关分析.结果 1000名受试者左、右侧内囊体积分别为(2809±393)、(2677±343) mm3,左侧大于右侧(t=12.078,P＜0.05).男性左、右侧内囊体积分别为(2863±396)、(2744±358)mm3,女性分别为( 2754±385)、( 2609±314 )mm3,男性左、右侧内囊体积均大于女性(t值分别为1.982、2.851,P值均＜0.05).5组上述不同年龄志愿者左侧内囊体积分别为(3273±361)、(2943±299)、(2777±255)、(2607±199)、(2444±213)mm3,右侧分别为(2993±361)、(2814±270)、(2682±239)、(2543±219)、(2351±210)mm3,5组间左、右侧内囊体积差异均有统计学意义(F值分别为55.244、34.493,P值均＜0.05).左、右侧内囊体积均与年龄呈负相关(r值分别为-0.718、-0.637,P值均＜0.05).结论1.5 TMR扫描仪能明确辨别内囊的边界,精确测量内囊体积;内囊体积与年龄呈负相关.     

中国汉族正常成人海马体积的高分辨率MRI测量

目的 测量中国汉族成人海马体积的正常值范围,为各种导致海马结构改变疾病的临床诊断和科学研究提供基础性数据.方法 采用全国多中心临床研究形式,选取18～70岁健康志愿者1000名,按照年龄18～30、31～40、41～50、51～60、61～70岁进行分组,每组男、女各100名.所有受试者均行3D磁化强度预备梯度回波序列T1WI,应用3D体积分析软件手工勾绘ROI,测量健康中国成年人海马的体积.采用多元线性回归方法探讨海马体积与性别、年龄、体重和身高的关系.不同性别、侧别间海马体积的差别采用两独立样本t检验.不同性别和年龄分组间采用方差分析.结果 左、右侧海马体积分别为(4752±659)、(5032±660)mm3,与性别和年龄相关(左、右侧r值分别为0.283和0.311,F值分别为30.127和37.050,P值均<0.01),而与身高和体重不相关(P<0.05).男性左、右侧海马体积分别为(4897±670)、(5192±667)mm3,女性左、右侧海马体积分别为(4647±624)、(4904±630)mm3,右侧海马体积均大于左侧(t值分别为7.030、6.696,P值均<0.05),男性左、右海马体积均大于女性(t值分别为6.586、7.326,P值均<0.05).男性5组左侧海马体积分别为(4981±684)、(5003±609)、(4976±657)、(4841±631)、(4631±681)mm3,右侧海马体积分别为(5340±647)、(5276±582)、(5264±620)、(5133±661)、(4894±699)mm3,5组间差异均有统计学意义(左、右侧F值分别为5.737和7.607,P值均<0.01),其中男性两侧海马结构在18～30、31～40、41～50岁组分别与61～70岁组比较,差异均有统计学意义(P值均<0.05),其余各组间差异无统计学意义(P>0.05).女性不同组别的海马体积差异无统计学意义(P>0.05).结论 采用高分辨率MRI获得中国汉族正常人不同年龄段的海马体积数据,为进一步研究海马相关疾病提供了基础性数据.     

中国汉族成人额叶体积的高分辨率MRI测量

目的 测量中国汉族正常成人大脑额叶体积,为建立中国成人数字标准脑提供基础数据.方法 采用全国多中心临床研究形式,选取18～70岁健康志愿者200名,按照年龄18～30、31～40、41～50、51～60、61～70岁进行分组,每组男、女各20名.所有受试者均行3D磁化强度预备梯度回波序列T1WI采集额叶体积,通过人工勾画ROI法分别测量志愿者左、右侧额叶体积,并对测量数据进行统计学分析.男、女性别间比较采用独立样本t检验;左、右侧别间比较采用配对样本t检验;年龄与额叶体积进行相关与回归分析.结果 200名志愿者大脑额叶总体积为(563±73)cm3.100名男性左、右侧额叶体积值分别为(288±42)、(292±41)cm3;100名女性左、右侧额叶体积值分别为(273±30)、(274±30)cm3.大脑额叶总体积男、女性别间差异有统计学意义(t=3.334,P<0.05).男性左、右侧额叶体积差异有统计学意义(t=-3.09,P<0.05),女性左、右侧额叶体积差异无统计学意义(t=-1.304,P>0.05).男性及女性大脑额叶总体积均与年龄呈负相关(r值分别为-0.586、-0.498,P值均<0.01).结论 健康国人男性额叶总体积大于女性.男性右侧额叶体积大于左侧,而女性双侧额叶体积差异无统计学意义.随着年龄的增长,男性及女性的额叶总体积均呈现逐渐缩小的趋势,男性额叶缩小的趋势比女性明显.