电针足三里不同配穴对大鼠急性胃黏膜损伤修复作用的比较研究

目的通过观察电针足三里不同配穴对大鼠急性胃黏膜损伤表皮生长因子、一氧化氮、胃泌素的影响,探讨各电针组对胃黏膜损伤修复作用的差异。方法将100只大鼠随机分为10组,即空白对照组、模型组、足三里组、足三里配内关组、足三里配中脘组、足三里配公孙组、足三里配内关中脘组、足三里配内关公孙组、足三里配中脘公孙组、足三里配内关中脘公孙组。用无水乙醇灌胃,造成急性胃黏膜损伤模型。检测各组胃黏膜损伤指数、表皮生长因子、一氧化氮、胃泌素。结果各电针组能提高表皮生长因子和一氧化氮含量,降低胃泌素含量,与模型组比较有统计学意义P(<0.05或P<0.01);足三里组、足三里内关组、足三里公孙组组间比较无统计学意义,而足三里内关公孙组、足三里中脘组、足三里内关公孙中脘组与足三里组比较有统计学意义;足三里内关公孙中脘组与其他各电针组比较有统计学意义。结论电针足三里不同配穴对大鼠急性胃黏膜损伤均具有修复作用,尤以足三里配内关中脘公孙组作用最强。     

EFFECT OF ELECTROACUPUNCTURE ON GASTRIC FUNCTIONAL ACTIVITY IN THE RAT

Ｉｔｉｓｗｅｌｌｋｎｏｗｎｔｈａｔｅｌｅｃｔｒｏａｃｕｐｕｎｃｔｕｒｅ(ＥＡ)ｈａｓａｎｅｖｉｄｅｎｔｒｅｇｕｌａｔｉｖｅｅｆｆｅｃｔｏｎｔｈｅｆｕｎｃｔｉｏｎａｌａｃｔｉｖｉｔｙｏｆｔｈｅ ｇａｓｔｒｏｉｎｔｅｓｔｉｎａｌｓｙｓ ｔｅｍ[1 ] ａｎｄｈａｓｂｅｃｏｍｅａｎｉｍｐｏｒｔａｎｔｍｅａｓｕｒｅｆｏｒｔｒｅａｔｉｎｇｄｉｓｅａｓｅｓｏｆｔｈｅｇａｓｔｒｏｉｎｔｅｓｔｉｎａｌｔｒａｃｔ[2 ] .Ｂｕｔｉｔｓｍｅｃｈａｎｉｓｍｓａｒｅｓｔｉｌｌｉｎｃｏｍｐｌｅｔｅｌｙｋｎｏｗｎａｔｐｒｅｓｅｎｔ.Ｒｅ…     

针刺足三里穴对鼠红细胞免疫功能影响的实验研究

 目的探讨针刺足三里穴对机体红细胞免疫的影响.方法将小鼠随机分为对照组和针刺组,针刺组每日针刺足三里穴,对照组不予针刺.11d后采用补体致敏酵母菌血凝法,并分别测定各组小鼠的脾脏系数,检测针刺足三里穴对小鼠红细胞免疫粘附功能的影响.结果在血凝滴度为1:16时,对照组与针刺组小鼠的阳性率有显著性差异(P＜0.01);脾脏系数分别为:对照组(5.79±0.88)mgg,针刺组(7.63±0.92)mg/g,针刺组明显高于对照组(P＜0.01).结论针刺三里穴对小鼠的红细胞免疫粘附功能有增强作用.     

电针足三里应用于脑卒中后痉挛状态的可行性研究

目的探讨针灸治疗对偏瘫痉挛期患者的疗效。方法63例脑卒中偏瘫痉挛期患者随机分为电针组(31例)和对照组(32例),均予常规康复训练,电针组同时给予电针足三里。比较两组患者治疗前后的综合痉挛量表评分、H/Mmax和肌肉的顺应性。结果电针组患者治疗后的综合痉挛量表评分、H/Mmax和腓肠肌内外侧头的顺应性均优于对照组(P<0.05～0.01)。结论针灸治疗可明显降低偏瘫痉挛期患者的肌张力,提高其运动功能。     

足三里注射新斯的明治疗住院患者便秘观察

探讨采用足三里注射新斯的明对治疗住院患者便秘的疗效。将228例患者分为观察组、对照1组和对照2组，观察组采用双侧足三里注射新斯的明治疗，对照1组采用口服麻仁润肠丸治疗，对照2组采用普通针灸治疗；观察3组患者排便时间、排便顺畅程度。3组之总有效率呈显著性差异，但对照1组的治愈率低于观察组和对照2组(P＜0.05)，且其治疗费用亦为3组中最高。足三里注射新斯的明治疗便秘是一简便易行、副作用少、临床疗效令人满意的方法。     

足三里穴化脓灸对结肠癌患者免疫功能的调节作用

目的:探讨足三里穴化脓灸对结肠癌患者免疫功能的调节作用。方法:将63例中晚期结肠癌患者随机分为治疗组31例和对照组32例。所有患者均给予化疗+扶正抑瘤肠方治疗,治疗组患者在此基础上加用足三里穴化脓灸治疗,观察周期为80 d。检测患者的免疫学指标,评价并比较两组患者的生活质量和化疗的毒副反应。结果:治疗后,对照组患者的CD4+、CD8+T细胞水平均显著降低(P0.05),治疗组患者CD8+T细胞水平显著降低(P0.05),且对照组患者的CD4+、CD8+T细胞水平低于治疗组(P0.05);治疗组患者的转化生长因子-β1(TGF-β1)水平显著降低(P0.05),且明显低于对照组(P0.05)。治疗后,对照组患者的总体生活质量评分显著降低(P0.05),且显著低于治疗组(P0.05);治疗组患者的躯体疼痛、精神健康维度评分升高(P0.05),对照组患者的躯体疼痛维度评分升高(P0.05),生理机能、总体健康、精力、精神健康维度评分降低(P0.05),且治疗组患者的总体健康、精神健康维度评分显著高于对照组(P0.05)。治疗后,治疗组患者的白细胞(WBC)水平显著升高(P0.05),且显著高于对照组(P0.05)。结论:化脓灸足三里穴结合中西医常规疗法治疗中晚期结肠癌患者,能够调节患者的免疫功能,提高患者的生活质量。     

中西医结合安全洗胃临床体会

洗胃是急诊科抢救口服药物中毒的重要措施之一,快速彻底地洗出毒物是抢救成功的关键。及时有效的彻底洗胃,导泻促进残留毒物排出,防止毒物进一步吸收是必不可少的环节。但在洗胃过程中,可能会出现一定的安全问题,如何安全有效地处理是文章所表述的。     

High-frequency electroacupuncture versus carprofen in an incisional pain model in rats

The objective of the present study was to compare the effect of electroacupuncture (EA) and carprofen (CP) on postoperative incisional pain using the plantar incision (PI) model in rats. A 1-cm longitudinal incision was made through skin, fascia and muscles of a hind paw of male Wistar rats and the development of mechanical and thermal hypersensitivity was determined over 4 days using the von Frey and Hargreaves methods, respectively. Based on the experimental treatments received on the third postoperative day, the animals were divided into the following groups: PI+CP (CP, 2 mg/kg, po); PI+EAST36 (100-Hz EA applied bilaterally at the Zusanli point (ST36)); PI+EANP (EA applied to a non-acupoint region); PI+IMMO (immobilization only); PI (vehicle). In the von Frey test, the PI+EAST36 group had higher withdrawal force thresholds in response to mechanical stimuli than the PI, PI+IMMO and PI+EANP groups at several times studied. Furthermore, the PI+EAST36 group showed paw withdrawal thresholds in response to mechanical stimuli that were similar to those of the PI+CP group. In the Hargreaves test, all groups had latencies higher than those observed with PI. The PI+EAST36 group was similar to the PI+IMMO, PI+EANP and PI+CP groups. We conclude that 100-Hz EA at the ST36 point, but not at non-acupoints, can reduce mechanical nociception in the rat model of incisional pain, and its effectiveness is comparable to that of carprofen.     

Long-term acupuncture treatment has a multi-targeting regulation on multiple brain regions in rats with Alzheimer's disease: a positron emission tomography study

The acute effect of acupuncture on Alzheimer’s disease,i.e.,on brain activation during treatment,has been reported.However,the effect of long-term acupuncture on brain activation in Alzheimer’s disease is unclear.Therefore,in this study,we performed long-term needling at Zusanli(ST36)or a sham point(1.5 mm lateral to ST36)in a rat Alzheimer’s disease model,for 30 minutes,once per day,for 30 days.The rats underwent 18F-fluorodeoxyglucose positron emission tomography scanning.Positron emission tomography images were processed with SPM2.The brain areas activated after needling at ST36 included the left hippocampus,the left orbital cortex,the left infralimbic cortex,the left olfactory cortex,the left cerebellum and the left pons.In the sham-point group,the activated regions were similar to those in the ST36 group.However,the ST36 group showed greater activation in the cerebellum and pons than the sham-point group.These findings suggest that long-term acupuncture treatment has targeted regulatory effects on multiple brain regions in rats with Alzheimer’s disease.     

针刺足三里及丰隆治疗顽固性心力衰竭30例临床观察

目的:观察针刺足三里、丰隆穴联合西药治疗顽固性心力衰竭(下称心衰)的临床疗效。方法:选取符合标准的90例顽固性心衰患者,采用随机数字表法分为针刺组、揿针组及对照组各30例,三组患者均给予基础强心利尿措施治疗,针刺组在常规西药基础上联合普通针刺足三里、丰隆,揿针组在常规西药基础上联合微型皮内针治疗,治疗4周后观察三组患者左室射血分数(LVEF)、血浆氨基末端脑钠肽前体(NT-proBNP)及明尼苏达心衰生活质量量表(MLHFQ)评分变化。结果:治疗后,三组患者的LVEF均增高,血浆NT-proBNP水平、MLHFQ评分均降低(P<0.01);针刺组的LVEF高于揿针组及对照组(P<0.01),血浆NT-proBNP、MLHFQ评分均低于揿针组及对照组(P<0.01);揿针组与对照组相比,LVEF、血浆NT-proBNP、MLHFQ评分差异均无统计学意义(P>0.05)。结论:针刺足三里、丰隆能显著改善心脏功能,提高患者的生活质量。