新斯的明足三里注射对原位肝移植术后腹胀患者腹内压的影响

目的: 探讨一种有效降低原位肝移植术后腹胀患者腹内压的方法.方法:原位肝移植术后腹胀患者20例, 给予新斯的明足三里注射, 分别在注射前5 min, 注射后60 min监测患者肠鸣音及腹内压变化情况, 准确记录患者排气排便时间.结果: 患者用药后排气/便时间为43±7.21 min, 足三里新斯的明注射后60 min, 患者腹内压由19.62±5.31 cmH2O下降到15.27±4.61 cmH2O, 肠鸣音由0.85±0.08次/min 增加到6.12±2.08次/min, 与注射前相比存在显著差异(P<0.01). 结论:新斯的明足三里注射可促进肠蠕动, 显著降低原位肝移植术后腹胀患者腹内压.     

电针足三里穴对应激性胃溃疡大鼠一氧化氮和儿茶酚胺的影响

本文对电针足三里穴抗“束缚－冷冻”应激性胃溃疡大鼠一氧化氮（ＮＯ）、多巴胺（ＤＡ）和去甲肾上腺素（ＮＥ）的含量进行了分析，结果如下：①应激性胃溃疡大鼠血清ＮＯ含量比对照组非常显著下降， Ｐ＜０． ０１，胃窦粘膜ＤＡ含量显著下降， Ｐ＜０． ０５，胃体粘膜ＤＡ呈增高趋势；②电针足三里穴引起应激性胃溃疡大鼠ＮＯ水平回回升，与应激组相比， Ｐ＜０．０１。电针引起胃窦和胃体粘膜ＤＡ、ＮＥ含量改变，有双向调节作用。即原降低者上升、原升高者下降，分别与应激组相比，均为Ｐ＜０． ０１。提示电针对胃粘膜的保护作用是通过对ＤＡ和 ＮＥ的双向调节，发挥了ＤＡ的调控作用，影响ＮＥ的水平，通过ＮＯ的舒血管作用，调节血流量，增强粘膜防御能力而实现的。     

电针足三里穴对兔肺缺血再灌注损伤脂质过氧化反应的影响

目的研究电针足三里穴对在体家兔肺缺血再灌注损伤的影响。方法28只新西兰家兔采用在体肺热缺血再灌注损伤模型．随机分四组（n=7）。A组：假手术组。左开胸游离支气管和肺动脉、静脉后维持通气180min。B组：缺血再灌注组，左开胸游离支气管和肺动脉、静脉后阻断左肺门60min．开放再通气120min。C组：阻断左肺门60min后．开放再通气即刻电针足三里穴旁5mm处30 min．继续双肺通气90min。D组：电针足三里穴＋缺血再灌注组，阻断左肺门60min后。开放再通气即刻电针足三里穴30min．继续双肺通气90min。观察并记录各组动物术中平均动脉压和心率的改变及实验结束时肺组织丙二醛（MDA）和髓过氧化物酶（MPO）含量以及肺组织湿/干重比（W/D）和血气变化。结果各组动物相应时间点的心率比较，均无统计学意义（P〉0.05）。自再灌注30min开始，与B组比较。C组平均动脉压显著降低（P〈0．05），D组平均动脉压与B组比较无统计学意义（P〉0．05）。B组肺组织MDA和MPO含量、W／D及PaCO2值均较A组升高．pH和PaO2值显著降低（P〈0．05或P〈0．01）；D组肺组织MDA和MPO含量、W／D及PaCO2值均较B组降低，pH和PaO2值显著升高（P〈0．05或P〈0．01）。结论电针家兔足三里穴可明显抑制肺缺血再灌注损伤时肺组织MDA和MPO的产生，减轻肺水肿的发生，改善血气变化及酸碱失衡．对在体家兔肺缺血再灌注损伤有一定的保护作用。     

针药结合治疗活动期湿热型溃疡性结肠炎疗效观察

目的:探讨针刺足三里结合口服膈下逐瘀汤治疗活动期湿热型溃疡性结肠炎的效果与相关机制.方法:活动期湿热型溃疡性结肠炎患者120例,以随机抽签方法分为观察组与对照组,各60例,对照组给予基础治疗结合口服膈下逐瘀汤治疗,观察组在此基础上给予针刺足三里,两组均治疗14天观察疗效、各症状评分以及血清白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)含量.结果:①治疗后观察组总有效率为98.3％ (59/60),明显高于对照组的86.7％(52/60,P＜0.05);②观察组溃疡、水肿、糜烂、息肉改善率明显高于对照组(均P＜0.05);③两组治疗后腹泻、脓血便、腹痛、里急后重症状评分和血清IL-1β、IL-6和TNF-α炎性因子与治疗前比较均明显下降(均P＜0.05),观察组与对照组组间比较差异有统计学意义(均P＜0.05);④治疗后随访3个月,观察组复发率为1.7％(1/59),明显低于对照组的11.5％ (6/52,P＜0.05).结论:膈下逐瘀汤结合针刺足三里治疗活动期湿热型溃疡性结肠炎能有效提高疗效,并降低复发率,缓解临床症状,促进黏膜的修复,其作用机制可能与降低炎性反应的表达有关.     

Central neuromechanisms underlying control of intragastric pressure through acupuncture atZusanli (ST36) in rats：the upper cervical cord is the key link between the ascending and descending pathways

Sensory inputs stimulated byZusanli (ST36) acupuncture in the abdomen are known to converge in the upper cervical cord. However, it is unclear whether these inputs are subsequently conveyed to the hypothalamic paraventricular nucleus and what kind of afferent ifbers are involved. We focused on the upper cervical cord, where afferent inputs converge, and detected c-fos expression in oxytocinergic neurons. We found thatZusanli acupuncture therapy effectively elevated intragastric pressure, but inhibited expression of c-fos in oxytocinergic neurons of the paraventricular nucleus in upper cervical cord injured rats. TheseZusanli acupuncture effects remained even after complete dorsal cord transection. However, after complete transection of the spinal cord or dorsolateral funiculus, the effects were signiifcantly at-tenuated and even disappeared. These ifndings suggest that the paraventricular nucleus is responsible for pooling and integrating signals from theZusanli acupuncture and sensory information from the intragastric pressure variation, thereby contributing to the regulation of intragastric pressure. The upper cervical cord serves as the key link between ascending and descending pathways, which conveys afferent inputs to the paraventricular nucleus through the dorsolateral funiculus.     

电针肥胖大鼠后三里或三阴交穴对脂肪代谢指标的影响

目的 观察电针单纯性肥胖大鼠的单穴后三里或三阴交穴对脂肪代谢的调节作用,探讨电针单穴减肥效应.方法 实验前后分别测定各组大鼠（每组8只）的体重、体长、Lee指数以及血清胆固醇（total cholesterol,TC）、三酰甘油（甘油三酯,triglyceride,TG）的含量变化,同时计算Lee指数,观察治疗2个疗程后的数据,用SPSS11.5软件进行数据统计处理.结果 治疗组与模型对照组、治疗组与非经非穴对照组在体重、Lee指数、TC、TG的差异均有统计学意义（P＜0.05或P＜0.01）;治疗组与普通饲料对照组体重、Lee指数、TC、TG的差异均无统计学意义（P＞0.05）.结论 电针后三里或三阴交对单纯性肥胖大鼠的治疗均具有显著性疗效,在减肥和减轻体重方面具有良性地改善调节功能,能减少Lee指数、降低血清TC、TG的浓度水平,其作用机制可能与改善和调节TC、TG代谢紊乱有关.     

Electro-acupuncture at Zusanli （ST 36） to improve lower extremity motor function in sensory disturbance patients with cerebral stroke A randomized controlled study of 240 cases

BACKGROUND： Studies have shown that sensory transduction is a way to introduce needle sensation. OBJECTIVE： To observe the influence of electro-acupuncture at the ＂Zusanll＂ （ST 36） point on lower extremity motor function in various sensory disturbance patients with cerebral stroke. DESIGN, TIME AND SETTING： A randomized, controlled, clinical study was performed at the Department of Neurological Rehabilitation, China Rehabilitation Research Centre from September 2006 to June 2008. PARTICIPANTS： Patients with first-time cerebral infarction or hemorrhage, or with a stroke history, but no neurodysfunction （single damage）, were selected for this study. The subjects were right-handed and disease state was stable. A total of 240 inpatients were randomly assigned to the following groups： electro-acupuncture （n = 124） and control （n = 116）. The two groups were further assigned into sub-groups： no sensory disturbance, superficial sensory disturbance, deep sensory disturbance, and deep and superficial sensory disturbance. METHODS： On the basis of routine limb function training, the acupoint Zusanliwas utilized in all patients from the electro-acupuncture group. Perpendicular acupuncture was 3.0-4.0 cm deep. An electric acupuncture instrument was connected when patients developed the needle sensation, deqi. A stimulation pattern consisting of distant and dense waves of 50 Hz was used to elicit slight dorsal foot extension. Acupuncture was administered 5 times per week, 30 minutes per session, for 6 weeks in total. MAIN OUTCOME MEASURES： FugI-Meyer assessment （FMA） was used to evaluate lower extremity motor function; Ver.1.0 gait analysis to estimate gait （step frequency, step speed, and step scope）; lower extremity Composite Spasticity Scale （CSS） to estimate muscle spastic degree. RESULTS： Following treatment, motor function improved in both groups. Compared with the control group, FMA score, step speed, step frequency, and step scope were increased in the electro-acupuncture group, but there was no difference in lower extremity CSS scores between the electro-acupuncture and the control groups （P 〉 0.05）. Compared with the control group, Zusanli （ST 36） electro-acupuncture improved motor function indices as follows： FMA score, step frequency, step speed, and step scope of patients with no sensory disturbance （P 〈 0.05-0.01）, step frequency of patients with superficial sensory disturbance （P 〈 0.05）, and step frequency and step speed of patients with deep sensory disturbance （P 〈 0.05）. CONCLUSION： Zusanfi （ST 36） electro-acupuncture effects on lower extremity motor function in stroke patients were improved with no muscle tone rise. Therefore, this form of treatment can be used in convalescent treatment, Moreover, effects were different according to various sensory disturbance types, which suggested that sensory input influenced acupuncture effects.     

电针正常人足三里和关元穴中枢效应的fMRI脑功能成像比较

目的:利用fMRI脑功能成像,比较电针时位于肢体的足三里穴及腹部的关元穴激活的脑功能区及其功能区网络连接的异同。方法:21名健康志愿者参加电针足三里穴、关元穴时的fMRI试验。分别在针刺前静息状态、留针、电针(15Hz,3次30s,间隔1min)、拔针后静息态采集fMRI脑功能数据,并记录电针任务时针感。采用t检验及卡方检验分析针感,SPM 2、短程和长程"中心度"法分析脑激活功能区及其之间的功能网络连接。结果:在电针电流无显著性差异条件下,电针足三里穴较关元穴诱导出了更强的胀满感及麻木感。电针两穴均产生了相似的前下扣带回-额叶内侧回网络的显著负激活效应,留针及电针能改变脑静息态脑功能默认功能模式,于额叶内侧回、扣带前回前下部短程脑功能网络出现了明显的即时针刺后效应。足三里穴较关元穴产生了更强的短程脑功能网络连接。结论:针刺足三里、关元穴具有显著相似的对脑边缘叶-额叶内侧皮层脑网络的调制作用,但也存在小的差异,体现穴位脑效应的相对特异性。     

电针“足三里”对失血性休克延迟补液大鼠肝组织缺血性损伤的影响

目的:研究电针“足三里”对失血性休克延迟补液大鼠肝组织血流量、含水率以及血浆谷丙转氨酶(ALT)的作用,为电针足三里治疗失血性休克提供依据.方法:取40只SD雄性大鼠按全血容量的40％放血制成失血性休克模型,再随机分为4组,模型对照组(NT),立即补液组(IFR),电针足三里延迟补液组(EA/DFR)和电针非经穴延迟补液组(SEA/DFR),每组10只.NT组造模后不做任何治疗处理;IFR组于失血后10 min即行补液;EA/DFR组于失血后10 min电针“足三里”穴,SEA/DFR组于失血后10 min电针非经穴部位,其他操作同EA/DFR组,两组均失血后3h实施延迟补液.测定失血前及失血后3h、12 h的肝组织血流量、ALT含量及失血后12h的肝组织含水率.结果:失血后IFR组和EA/DFR组各指标与NT组比较均有显著改善(均P＜0.05),而SEA/DFR组与NT组间各指标无显著差异.失血后3h,IFR组的肝组织血流量显著高于NT组、EA/DFR组及SEA/DFR组(均P＜0.05),血浆ALT显著低于NT组、EA/DFR组及SEA/DFR组(均P＜0.05),EA/DFR组血浆ALT水平显著低于NT组、SEA/DFR组(均P＜0.05),而肝组织血流量与SEA/DFR组比较无显著差别(P＞0.05).失血后12 h,EA/DFR组和IFR组血浆ALT水平和肝组织含水率均显著低于NT组、SEA/DFR组(均P＜0.05),肝组织血流量均显著高于NT组、SEA/DFR组(均P＜0.05);而IFR组的血浆ALT显著低于EA/DFR组(P＜0.05),肝组织血流量显著高于EA/DFR组(P＜0.05).结论:电针“足三里”穴对失血性休克延迟补液大鼠肝组织缺血性损伤具有一定保护作用.     

穴位敷贴对运动性疲劳运动员生化指标及主观体力感觉评分的影响(英文)

目的:观察穴位敷贴治疗对运动性疲劳者生化指标及主观体力感觉评分(Rating of Perceived Exertion,RPE)的影响。方法:将35名足球运动员随机分成3组,即空白组、对照组、观察组。空白组不予治疗,观察组予穴位敷贴治疗,对照组口服西洋参。每天记录受试者RPE,试验前后检测受试者血红蛋白(Hemoglobin,Hb)、红细胞计数(Red Blood Cell Count,RBC)、血尿素氮(Blood UreaN itrogen,BUN)和血糖(Blood Glucose,BG)。结果:空白组RPE值呈上升趋势,观察组和对照组的RPE值都呈先上升后下降的趋势,观察组的RPE值比对照组对应值小。试验前后比较,空白组Hb、RBC和BG降低,BUN增高。观察组和对照组Hb、RBC和BG升高,BUN降低。结论:穴位敷贴能缓解运动性疲劳的临床症状。