南岭前胡素A的结构鉴定

从前胡属新种植物南岭前胡(Peucedanum longshengense Shan et Sheh)根中首次分离得到2个单体化合物,经理化常数、波谱数据解析,分别鉴定为南岭前胡素A(I)和甘露醇(II)。晶I为一新化合物,通过和凯林内酯的化学沟通确定其绝对构型,化学结构为(-)-3′(S)-乙酰氧基-4′(S)-当归酰氧基-3′,4′-二氢邪蒿内酯。     

前胡香豆素B和前胡香豆素C的分离和鉴定

从中药白花前胡(Peucedanum praeruptorum)根中分离和鉴定了5个化合物,经理化常数测定,波谱数据解析及化学反应,分别鉴定为3′-angeloyloxykhellactone(Ⅸ)、前胡香豆素B(Ⅹ)、前胡香豆素C(Ⅺ)、Pd-Ⅲ(ⅩⅢ)和peucedanocoumarin Ⅲ(ⅩⅤ)。其中化合物Ⅹ和Ⅺ为两个新化合物,通过和凯林内酯的化学沟通确定了其绝对构型。其化学结构分别为3′(S)-乙酰氧基-4′(S)-羟基-3′,4′-二氢邪蒿内酯(Ⅹ)和3′(S)-羟基-4′(S)-乙酰氧基-3′,4′-二氢邪蒿内酯(Ⅺ)。Ⅸ为首次报道自天然物中分得。     

中药白花前胡根中香豆素白花前胡素(E)的分离鉴定

从白花前胡(Peucedanum praeruptorum Dunn)根的醚提取物中除分得已知香豆素白花前胡丙素和另一种结晶外,还分得一种具有生理活性的香豆素单体,命名为(+)白花前胡素(E)[(+)praeruptorin E]。经元素分析、紫外、红外、质谱、核磁、气相及水解产物的鉴定,证明白花前胡素(E)为(+)3′-当归酰基-4′-异戊酰基-顺式-凯林酮(+)3′-angeloyl-4′-isovalerylcis-khellactone,此香豆素对小白鼠具有耐缺氧作用。关于其他成分,将另有报告。     

马尾松松针化学成分的研究

目的　研究松科植物马尾松(P.massoniana Lamb .)松针的化学成分。方法　利用色谱技术分离纯化,根据化合物的理化性质和光谱数据进行结构鉴定。结果　从马尾松针水煎液的正丁醇部位分离得到3个化合物,分别鉴定为:莽草酸(shikimicacid ,1) ,cedrusin [(7S ,8R)-3′,4 ,9,9′-四羟基-3- 甲氧基-7,8-二氢苯并呋喃-1′-丙醇基新木脂素,2],massonianoside B [(7S ,8R)-3 ,9,9′-三羟基-3-甲氧基-7,8-二氢苯并呋喃-1′-丙醇基新木脂素-4-O-α-L-鼠李糖苷,3]。结论　化合物3为新化合物,化合物1和2是首次从本植物中分离得到。     

海风藤中新木脂素类PAF拮抗活性成分的研究

自中药海风藤[Piper kadsura (Choisy)Ohwi]的藤茎中又分离得到四个macrophyllin型双环[3,2,1]辛烷类新木脂素,经光谱分析及衍生物的制备,确定化合物Ⅰ和Ⅲ为新结构,命名为风藤素K(kadsurenin K)和风藤素L(kadsurenin L),其化学结构分别为7R,8R,3′R,5′R-△^8′-3,5′-二甲氧基-4-羟基-2′,3′,4′,5′-四氢-2′,4′-氧-7.3′,8.5′-新木脂素(Ⅰ)和7R,8R,3′S,4′R,5′R-△^8′-3,4,5′-三甲氧基-4′-乙酰氧基-2′,3′,4′,5′-四氢-2′-氧-7.3′,8.5′-新木脂素(Ⅲ)。化合物Ⅱ和Ⅳ分别为已报道过的风藤素C和风藤素B。化合物Ⅰ～Ⅳ均有明显的PAF受体拮抗活性。     

前胡香豆素A的分离和结构鉴定

从中药白花前胡(Peucedanum praeruptorum Dunn)根中分离得到7个化合物,经理化常数和波谱数据的测定以及化学反应,鉴定为补骨脂素(Ⅱ)、5-甲氧基补骨脂素(Ⅲ)、8-甲氧基补骨脂素(Ⅳ)、北美芹素(Ⅴ)、peucedanocoumarin Ⅱ(Ⅵ)、β-谷甾醇(Ⅶ)和前胡香豆素A(Ⅷ)。Ⅷ为一新化合物,通过和凯林内酯的化学沟通确定了其绝对构型,化学结构为3′(R)-羟基-4′(E)-惕各酰氧基-3′,4′-二氢邪蒿内酯。Ⅱ～Ⅳ和Ⅶ为首次从白花前胡中分离得到。     

紫花松果菊水溶性成分研究

目的研究紫花松果菊的化学成分。方法用色谱法分离化合物，用波谱法鉴定其结构。结果从紫花松果菊分离得到5个化合物,其结构分别鉴定为2-(4-羟基苯基)乙基-O-α-L-鼠李糖基(1→6)-β-D-葡糖苷(1),(6S,9R)6羟基-3-酮-α-紫罗兰醇-9-O-β-D-葡糖苷(roseoside)(2),ampelopsisionoside (3),苯甲基-O-β-木糖基(1→6)-β-D-葡糖苷(β-primererosides)(4),苯甲基-O-β-D葡糖苷(5)。结论化合物1为新化合物，命名为紫花松果菊苷A(echipuroside A)，其余化合物均为首次从本属植物获得。     

马尾松松针中木脂素苷的分离与结构鉴定

目的研究松科(Pinaceae)植物马尾松(PINUS MASSONIANA Lamb.)松针(pine needles)的化学成分。方法利用DIAION HP-20,TOYOPEARL HW-40等色谱技术分离纯化,根据化合物的理化性质和光谱数据(UV,IR,MS,^{1H-1<>/supH COSY,HMQC,DEPT,HMBC和ORD等)进行结构鉴定。结果从马尾松松针水煎液的正丁醇萃取部位分离得到3个化合物,分别鉴定为化合物4(massonianoside A):(7S,8R)-3,4,9′-三羟基-3-甲氧基-7,8-二氢苯并呋喃-1′-丙醇基新木脂素-9-o-α-L-鼠李糖苷;化合物5(massonianoside C):(7S,8R)-9,9′-二羟基-3,3′-二甲氧基-7,8-二氢苯并呋喃-1′-丙醇基新木脂素-4-o-α-L-鼠李糖苷;化合物6(cedrusin-4-o-β-glucoside):(7S,8R)-3,9,9′-三羟基-3-甲氧基-7,8-二氢苯并呋喃-1′-丙醇基新木脂素-4-o-β-D-葡糖苷。结论化合物4和5为新化合物。}     

芝麻花化学成分的研究

芝麻花为胡麻科植物胡麻Sesamum indicum L.(S.orientale L.)的干燥花,有生发、消肿之功效,可治疗脱发、冻疮、便秘等。民间单方芝麻花治疗寻常疣、扁平疣等,均有满意的疗效。目前人们对芝麻种子的化学成分研究较多,但尚没有人对芝麻花的化学成分进行系统研究。本研究运用硅胶柱、凝胶柱、反相柱等多种色谱方法进行分离纯化,并根据理化性质和波谱数据鉴定化合物的结构。从其乙醇提取物的乙酸乙酯和正丁醇部位分别得到10个化合物,分别鉴定为latifonin (1),苦瓜脑苷(momor-cerebroside,2),大豆脑苷II(soya-cerebroside II,3),1-O-β-D-葡糖-(2S,3S,4R,5E,9Z)-2-n-(2′-羟基二十四碳酰氨基)-1,3,4-三羟基-十八碳-5,9-二烯［1-O-β-D-glucopyranosyl-(2S,3S,4R,5E,9Z)-2-n-(2′-hydroxytetra-cosanoyl) 1,3,4-trihydroxy-5,9-octadienine,4］,1-O-β-D-葡糖-(2S,3S,4R,8Z)-2N-(2′-羟基二十四碳酰氨基)-3,4-二-羟基-8-十八碳烯［1-O-β-D-glucopyranosyl-(2S,3S,4R,8Z)-2-n-(2′R) 2′-hydroxytetracosanoyl)-3,4-dihydroxy-8-octadene,5］,2-乙酰橙酰胺［(2S,1″S)-aurantiamide acetate,6］,苯基乙醇-O-(2′-O-β-D-吡喃鼠李糖,3′-O-β-D-吡喃葡糖)-β-D-吡喃葡糖［benzyl alcohol-O-(2′-O-β-D-xylopyranosyl, 3′-O-β-D-glucopyranoside)-β-D-glucopyranoside,7］,β-谷甾醇(8),胡萝卜苷(9),D-半乳糖醇(10)。其中化合物4为新化合物,所有化合物均为首次从该植物的花中分离得到。     

白花败酱草化学成分的分离与结构鉴定

目的研究白花败酱草的化学成分。方法利用溶剂萃取后进行硅胶柱和制备液相色谱分离纯化，根据理化性质和光谱数据鉴定结构。结果分离并鉴定了8个化合物：bolusanthol B (1)，(2S)-5,7,2′,6′-四羟基-6,8-二异戊烯基-二氢黄酮(2)，orotinin (3)，(2S)-5,7,2′,6′-四羟基-6-lavandulyl-二氢黄酮(4)，3′-异戊烯基-芹黄素(5)，木犀草素(6)，槲皮素(7)和洋芹素(8)。结论化合物2，4为新化合物，1，3，5为首次从败酱属植物中分离得到，6，7，8为首次从白花败酱草中分离得到。     

Studies on coumarins of a chinese drug "Qian-Hu"

Three new and four known coumarins were isolated from a Chinese drug "Zi-Hua Quian-Hu" (Shikazenko in Japanese), the root of PEUCEDANUM DECURSIVUM M AXIM. (Umbelliferae). The new compounds were proved to be 3'(S)-senecioyloxy-4'(R)-hydroxy-3',4'-dihydroxanthyletin, 3' (S)-hydroxy-4' (R)-senecioyloxy-3',4'-dihydroxanthyletin and 3'(S)-angeloyloxy-4'(R)-acetoxy-3',4'-dihydroxanthyletin. The known coumarins were identified to be decursidin, bergapten, nodakenetin and nodakenin, respectively.     

Coumarins from "Zi-Hua Qian-Hu" (supplement)

Two new and six known coumarins were obtained from the Chinese drug sold in the market under the name of Si-Oian-Hu (Seizenko). The new compounds were proved to be 3'( S)-acetoxy-4'( R)-isovaleryloxy- and 3'( S)-acetoxy-4'( R)-angeloyloxy-3',4'-dihydroxanthyletin, respectively. Mass spectrometry was applied to determine the different locations of ester moieties at the 3' and 4' positions without using alkaline hydrolysis. The present material, Si-Qian-Hu, should be identified with Zi-Hua Qian-Hu (the root of PEUCEDANUM DECURSIVUM), since it contains xanthyletin-type coumarins.     

Structures of Angular Pyranocoumarins of Bai-Hua Qian-Hu, the Root of Peucedanum praeruptorum1

Three new angular-type dihydropyranocoumarins, peucedanocoumarin I ( 1), peucedanocou-marin II ( 2), peucedanocoumarin III ( 3), and a known coumarin having the same skeleton, pteryxin ( 4), were isolated from the crude drug "Bai-Hua Qian-Hu" of the Q-II type series, which is the root of PEUCEDANUM PRAERUPTORUM Dunn. (Umbelliferae). The chemical structures of 1, 2, and 3 have been established by physicochemical methods to be 3' ( S)-2-methylbutyryloxy-4'-( R)-acetoxy-3',4'-dihydroseselin, 3'( S)-acetoxy-4'( R)-angeloyloxy-3',4'-dihydroseselin, and 3'( S)-acetoxy-4'( R)-tigloyloxy-3',4'-dihydroseselin, respectively.     

中药白花前胡化学成分的研究——四种新香豆素的结构

中药白花前胡(Peucedanum praeruptorum Dunn.)根的醚提部分中分得四种新香豆素,命名为白花前胡甲素((±)-praeruptorin A)、白花前胡乙素((±)-praeruptorin B)、白花前胡丙素((±)-praeruptorin A)和白花前胡丁素((+)-praeruptorinB),分别确定了它们的化学结构为[Ⅰ],[Ⅱ]、[Ⅲ]和[Ⅳ]式。其中[Ⅰ]和[Ⅲ]、[Ⅱ]和[Ⅳ]分别是消旋体和化学活性体的关系。此外,由纸层析检出了紫花前胡甙[Ⅴ]的存在并分得了D-甘露醇。白花前胡丙素[Ⅲ]及其双氢化物[ⅩⅥ]在离体豚鼠心上具有明显增加冠脉血流量的作用。     

Studies on coumarins of a chinese drug "Qian-Hu"

From the ether-soluble fraction of methanolic extracts of a Chinese Drug "Bai-Hua Quian-Hu", the root of Peucedanum praeruptorum (Umbelliferae), four coumarin compounds, (+/-) praeruptorin A, (+) praeruptorin B (= (+) anomalin), Pd-III and Pd-Ib, were isolated. The chemical structures of Pd-III and Pd-Ib have been established to be (+) 3' ( S)-angeroyloxy-4' ( S)-isovaleryloxy-3', 4'-dihydroseselin and (+) 3' ( R)-angeroyloxy-4'-keto-3',4'-dihydroseselin, respectively. (13)C NMR spectra of these compounds are also discussed.     

Coumarins from Peucedanum wulongense

A new angular dihydropyrancoumarin named wulongensin A, along with five known coumarins, (-)-anomalin, umbelliferone, (-)-smyrinol, 3'(S),4'(S)-disenecioyloxy-3',4'-dihydroseselin, (+)-trans-khellactone, was isolated from the root of Peucedanum wulongense. The structure of wulongensin A was established as 3'(R)-angeloyloxy-4'(R)-isovaleryloxy-3',4'-dihydroseselin by spectroscopic methods and the absolute configurations were deduced by chemical correlations with known compounds.     

Two compounds from Peucedanum dissolutum

A new compound, 3'(R)-O-beta-D-glucopyranosyl-3',4'-dihydroxanthyletin (1), and a known compound, prim-O-glucosylcimifugin (2), were isolated from the roots of Peucedanum dissolutum. The structure of 1 was elucidated by spectral evidence and chemical reaction. The NMR signals of carbons and protons of 2 were assigned for the first time by analysis of (1)H-(1)H COSY, HMQC and HMBC spectra.