| 中药白花前胡化学成分的研究——四种新香豆素的结构 |
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| 引用本文： | 陈政雄,黄宝山,佘其龙,曾广方.中药白花前胡化学成分的研究——四种新香豆素的结构[J].药学学报,1979,14(8):484-496. |
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| 作者姓名： | 陈政雄 黄宝山 佘其龙 曾广方 |
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| 作者单位： | 中国科学院上海药物研究所
(陈政雄，黄宝山，佘其龙)，中国科学院上海药物研究所(曾广方) |
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| 摘 要： | 中药白花前胡(Peucedanum praeruptorum Dunn.)根的醚提部分中分得四种新香豆素,命名为白花前胡甲素((±)-praeruptorin A)、白花前胡乙素((±)-praeruptorin B)、白花前胡丙素((±)-praeruptorin A)和白花前胡丁素((+)-praeruptorinB),分别确定了它们的化学结构为Ⅰ],Ⅱ]、Ⅲ]和Ⅳ]式。其中Ⅰ]和Ⅲ]、Ⅱ]和Ⅳ]分别是消旋体和化学活性体的关系。此外,由纸层析检出了紫花前胡甙Ⅴ]的存在并分得了D-甘露醇。白花前胡丙素Ⅲ]及其双氢化物ⅩⅥ]在离体豚鼠心上具有明显增加冠脉血流量的作用。
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| 收稿时间： | 1978-09-18 |
THE CHEMICAL CONSTITUENTS OF BAI-HUA-QIAN-HU, THE ROOT OF PEUCEDANUM PRAERUPTORUM DUNN. (UMBELLIFERAE)——FOUR NEW COUMARINS |
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| Chen Zhengxiong,Huang Baoshan She Qilong and Zeng Guangfang.THE CHEMICAL CONSTITUENTS OF BAI-HUA-QIAN-HU, THE ROOT OF PEUCEDANUM PRAERUPTORUM DUNN. (UMBELLIFERAE)——FOUR NEW COUMARINS[J].Acta Pharmaceutica Sinica,1979,14(8):484-496. |
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| Authors: | Chen Zhengxiong Huang Baoshan She Qilong and Zeng Guangfang |
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| Abstract: | The ether or petr. ether extract of the root of Peucedanum praeruptorum Dunn. afforded four coumarins: (±)-praeruptorin A (Ⅰ), (±)-praeruptorin B (Ⅱ), (+)-praeruptorin A (Ⅲ), and (+)-praeruptorin B (Ⅳ). (Ⅰ) and (Ⅱ) were the racemates of (Ⅲ) and (Ⅳ), respectively.The structures of (Ⅲ) and (Ⅳ) were elucidated as 3'(S)-angeloyloxy-4' (S)-acetoxy-3', 4'-dihydroseselin and 3'(S), 4'(S) -diangeloyloxy-3', 4'-dihydroseselin, respectively. (Ⅲ) was an antipode of isopteryxin and (Ⅳ) was an antipode of anomalin.Besides, mannitol was also isolated and nodakenin (Ⅴ) was detected by paper chromatography.(Ⅲ) and its dihydroderivative (ⅩⅥ) were found to increase coronary blood flow on isolated guinea pig heart. |
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