康复期男性海洛因依赖者听觉P300电位与毒品渴求状态研究

目的 探讨康复期男性海洛因依赖者(MPHD)听觉P300电位,以及在毒品渴求状态下的P300改变情况.方法 横断面对照研究纳入康复期MPHD患者20例,健康对照20例.两组对象均完成标准听觉P300测试.患者组还完成观看中性视频和海洛因诱发视频后的听觉P300测试.结果 标准听觉P300测试中患者组在Cz、Pz的P300波幅[(2.72±1.90)μV;(4.48±1.87)μV]低于健康对照组[(3.99±1.74) μV;(5.61±1.39)μV],差异有统计学意义(P＜0.05).有毒品相关视频心理渴求的患者观看毒品相关视频后Pz导联的P300波幅[(5.00±1.68)μV]高于观看中性视频后的波幅[(4.19± 1.62)μV],差异有统计学意义(P＜0.05).结论 康复期MPHD患者存在认知功能损害;P300指标可部分反映其在渴求状态下的注意力活跃状态.     

难治性精神分裂症患者认知异常的事件相关电位研究

目的 探讨难治性精神分裂症患者诱发电位P300和失匹配负波(MMN)的特征.方法 对21例难治性精神分裂症患者(病例组)和26名健康被试(对照组)行事件相关电位P300和MMN检测,比较两组被试F3、F4、Fz、Cz点P300和Fz、Cz、Pz点MMN的差异.结果 ①病例组反应时[(408.91±202.24)ms]长于对照组[(361.60±254.32) ms],差异具有统计学意义(P＜0.05).②病例组P300潜伏期在F3、F4、Fz、Cz四点[分别为(385.92±53.14)ms,(400.31±51.32) ms,(386.77±62.68) ms,(374.77±57.61)ms]长于对照组[分别为(341.00±30.42)ms,(335.23±29.71)ms,( 338.65±30.09) ms,( 344.42±30.86) ms],病例组波幅在F4、Fz两点[分别为(4.68±2.90)μV,(5.83±3.73) μV]比对照组[分别为(6.71±2.57) μV,(7.99±2.78)μV]低,均差异具有统计学意义(均P＜0.05).③病例组MMN在Fz点波幅[(2.77±2.25)μV]低于对照组[(5.87±3.28)μV],差异具有统计学意义(P＜0.05).对照组脑中央电极从前向后波幅逐渐降低,而病例组却与此相反.结论 难治性精神分裂症患者认知功能受损,事件相关电位技术可以为其提供生物学基础.     

珠心算训练对儿童形状识别影响的事件相关电位研究

目的 探讨珠心算训练对儿童形状识别的影响.方法 采用事件相关电位(ERP)技术对14名珠心算训练儿童和14名非珠心算训练儿童进行不同形状识别时的ERP记录,分析两组儿童不同脑区ERP波幅和潜伏期的差异.结果 (1)两组儿童枕部P1波幅差异显著,珠心算儿童的P1波幅[(9.59±3.58)μV]高于非珠心算儿童[(7.06 ±2.84)μV],差异具有显著性(P＜0.05);(2)珠心算儿童右侧枕颞区N170波幅[(-9.83 ±2.97)μV]小于非珠心算儿童[(- 12.45 ±2.51)μV],差异具有显著性(P＜0.05);(3)珠心算儿童前额P3波幅[(7.65 ±2.25)μV]大于非珠心算儿童[(4.89±3.35) μV],差异具有显著性(P＜0.05).结论 珠心算训练对儿童形状识别的脑功能有一定影响.     

海洛因依赖者的脑干听觉诱发电位和事件相关电位P300研究

目的探讨海洛因依赖者的脑干听觉诱发电位(BAEP)和事件相关电位(ERP)P300的变化特点及其应用.方法使用意大利Galileo Sirius数字化32导脑诱发电位仪对32例海洛因依赖者BAEP和P300检查,并与30例正常人比较.结果 (1)海洛因依赖者BAEP的波Ⅱ-波Ⅶ绝对潜伏期[依次为(2.67±0.12)μV,(3.82±0.16)μV,(4.95±0.17)μV,(5.11±0.12)μV,(6.61±0.17)μV,(7.52±0.14)μV]较正常对照组延长(P＜0.05),绝对波幅[依次为(0.16±0.10)μV,(0.29±0.09)μV,(0.36±0.12)μV,(0.41±0.11)μV,(0.26±0.11)μV,(0.27±0.10)μV]降低(P＜0.05),而波I差异无显著性(P＞0.05).(2)海洛因依赖者P300的潜伏期M[(89.47±15.02)ms]较正常人缩短(P＜0.05),潜伏期P3[(320.23±19.01)ms]较正常人延长(P＜0.05).结论海洛因依赖者存在一定程度的脑功能损害,其BAEP和P300变化特点既可作为辅助诊断依据又可为海洛因的戒断分析时提供神经电生理基础.     

冲动性人格障碍和焦虑症患者视觉诱发电位的对照研究

目的 探讨冲动性人格障碍(IPD)和焦虑症(AN)在视觉诱发电位(VEP)中的特点.方法 收集25例IPD组、33例AN组及52名正常成人对照(NC),以光刺激完成VEP检查.结果 IPD组和AN组及NC组在潜伏期VEP/P1、P2、P3波幅VEP/N1-P2、P2-N2、P2、P3上差异有显著性(P＜0.05或0.01).与NC相比,IPD组潜伏期VEP/P1[(68±16)ms]、P2[(160±10)ms]前移,波幅VEP/N1-P2[(18.4±3.2)μV]、P3[(5.6±2.4)μV]增高,但波幅VEP/P2-N2[(6.3±2.7)μV]、P2[(9.0±2.4)μV]降低.与NC相比,AN组潜伏期VEP/P1[(73±20)ms]、P3[(298±22)ms]前移;波幅VEP/P2-N2[(7.8±3.6)μV]、P2[(9.8±3.0)μV]降低.IPD组与AN组相比,在潜伏期VEP/P2以及波幅VEP/N1-P2上两者差异有显著性,IPD前移于AN,波幅增高.结论 在VEP若干指标上,IPD组前移于AN组,波幅增高.     

正常儿童汉字语义自动及控制加工事件相关电位比较

目的 分析正常儿童汉字自动加工和控制加工的事件相关电位(event-related potentials ,ERP)波形的特征,探讨正常儿童汉字识别及理解的神经机制.方法 8岁组儿童35名,11岁组儿童40名,采用汉字控制及自动加工任务两种刺激任务分别对儿童进行检测, BESA软件提取ERP进行比较分析.结果 ①行为学结果显示:2组反应时比较自动加工[8岁与11岁分别为:(710.61±136.16)ms, (516.52±75.38)ms]均快于控制加工[分别为:(898.87±129.63)ms,(810.12±93.41)ms],差异有显著性(P＜0.01).②8岁与11岁儿童的汉字自动与控制加工ERP潜伏期比较差异无显著性(P＞0.05).③8岁与11岁儿童自动加工二类字组的N2波幅[分别为:(-11.54±5.77) μV,(-9.65±4.23) μV]明显低于控制加工任务[分别为(-19.55±10.29) μV,(-17.87±7.60) μV],差异有显著性(P＜0.01).结论 本研究提示N2是与语义加工强相关的ERP成分,并且随着投入注意资源量的增多波幅增大,其波幅的变化可以用来衡量人们语义处理时投入的注意资源的多少.     

军人心理创伤后应激障碍与适应障碍患者事件相关电位的对照研究

目的 :目的探讨军人心理创伤后应激障碍 (PTSD)与适应障碍 (AD)患者三种事件相关电位 (ERP)的变异。 方法 :应用美国NicoletBravo脑诱发电位仪 ,采用光和声成对刺激、反应时间以及听觉靶 -非靶刺激序列技术 ,检测 66例PTSD和 62例AD的关联性负变(CNV)、P30 0 、以及失配性负波 (MMN)。 结果 :( 1)CNV :M1 潜伏期PTSD组 [( 5 0 3 4± 13 9 2 )ms]长于AD组 [( 42 1 4± 98 0 )ms;P <0 0 1] ,M2 波幅PTSD组 [( 18 9± 7 9) μv]高于AD组 [( 12 6± 5 2 ) μv ;P <0 0 1] ,指令信号后负变化 (PINV)的出现率PTSD组 ( 3 9% )高于AD组( 5 % ;P <0 0 1)。 ( 2 )P30 0 :在靶刺激中 ,Cz脑区的P3潜伏期PTSD组 [( 3 15 4± 17 8)ms]短于AD组 [( 3 3 8 9± 12 4)ms;P <0 0 1] ,Pz脑区的N2 潜伏期PTSD组 [( 2 78 5± 2 1 8)ms]长于AD组 [( 2 60 1± 15 6)ms ;P <0 0 1) ,Pz脑区的P3波幅PTSD组 [( 3 4± 1 8) μv)低于AD组[( 5 7± 2 4) μV ;P <0 0 1]。在非靶刺激中 ,Cz脑区的P2 波幅PTSD组 [( 2 5± 1 4) μV)低于AD组 [( 3 1± 0 1) μv ;P <0 0 1)。 ( 3 )MMN :潜伏期PTSD组 [( 2 14 2± 2 5 7)ms]长于AD组 [( 188 2± 2 0 9)ms;P <0 0 1] ,波幅PTSD组 [( 8 5± 1.8) μV]高于AD组 [( 5     

甲基苯丙胺使用障碍者风险决策行为的事件相关电位研究

目的探讨甲基苯丙胺使用障碍者风险决策行为的事件相关电位特点,从风险决策行为角度来了解甲基苯丙胺使用障碍的神经生物学机制。方法甲基苯丙胺并使用障碍组(MA组):43例,和健康对照组(HC):44例,两组分别于入组时进行中国修订版韦氏成人智力量表(WAIS-RC)、简易精神状态检查表(MMSE)、汉密尔顿抑郁量表(HAMD)评定。以及执行爱荷华赌博任务并同时进行事件相关电位数据采集。结果 MA组爱荷华赌博任务净分数(1.61±1.51)分,低于健康对照组净分数(5.78±3.69)分,差异有统计学意义(P0.05);MA组P300潜伏期(356.16±26.42)ms,较健康对照组(314.63±21.67)ms长、P300波幅[(6.16±1.16)μv]低于健康对照组[(7.86±1.39)μv],差异均有统计学意义;MA组ERN波幅(4.49±1.42)μv低于HC组的(6.58±1.80)μv(P0.05),FRN波幅(10.70±1.88)μv高于健康对照组的(7.27±1.43)μv,差异有统计学意义(P0.05)。两组ERN潜伏期、FRN潜伏期差异无统计学意义(P0.05)。结论甲基苯丙胺使用障碍者存在冲动性决策行为,事件相关电位揭示了甲基苯丙胺使用障碍者存在错误评估、结果反馈能力及认知功能损害。     

伴攻击或暴力行为精神分裂症患者事件相关电位P300研究

目的 探讨伴攻击或暴力行为精神分裂症患者的电生理机制.方法 根据诊断标准,对住院及门诊的精神分裂症患者采用修改版外显攻击量表(MOAS)评定其攻击行为,将符合条件的患者分为攻击或暴力行为精神分裂症组(攻击组,n=70)和非攻击或暴力行为精神分裂症组(非攻击组,n＝65),按照年龄、性别等匹配原则收集健康对照组(n=60),使用日本光电公司生产的MEB-9200诱发功能仪对所有受试者进行P300测试.结果 (1)在Cz点上,P3a的潜伏期攻击组[(344.0±33.0)ms]长于非攻击组[(328.3±28.0)ms] (P=0.01),非攻击组又长于健康组[(310.1±24.0)ms],差异均有统计学意义(P＜0.01);在Fz点上,P3a的潜伏期攻击组[(348.2±30.1)ms]长于非攻击组[(333±28.5)ms],非攻击组又长于健康组[(312.3±25.4)ms],差异均有统计学意义(P＜0.01).(2)在Cz点上,N2’的波幅攻击组[(6.96±7.2)μV]均高于非攻击组[(3.85±5.4)μV]及健康组[(3.6±4.2)μV],差异均有统计学意义(P＜0.05),而非攻击组及健康组间差异无统计学意义(P=0.985).结论 伴攻击或暴力行为的精神分裂症患者的事件相关电位P300有其特征性的电生理状态指标改变.     

首发精神分裂症患者错误相关负电位变异的初步研究

目的 探讨首发精神分裂症患者错误相关负电位(ERN)的变异及相应脑激活区.方法 在2010年3月至2011年2月,应用德国Brain Products公司的ERP记录与分析系统,对上海交通大学医学院附属精神卫生中心58例首发精神分裂症患者和62名健康成人做了ERN检测及脑激活部位的比较.结果(1)与健康对照组相比,首发精神分裂症ERN潜伏期在Cz(健康对照组:49ms±13 ms,患者组:58 ms±14 ms,P＜0.01)、Fz(健康对照组:47 ms±13 ms,患者组:60 ms±11 ms,P＜0.01)、C3(健康对照组:50 ms±14 ms,患者组:57 ms±17 ms,P＜0.05)和C4(健康对照组:51 ms±12 ms,患者组:60 ms±13 ms,P＜0.01)上明显延迟,波幅Cz(健康对照组:7.5μV±3.1 μV,患者组:5.0 μV±2.8 μV,P＜0.01)、C3(健康对照组:8.0μV±3.7 μV,患者组:5.5 μV±4.0μV,P＜0.01)、Fz(健康对照组:7.7 μV ±3.8 μV,患者组:5.0 μV±3.1 μV,P＜0.01)、Pz(健康对照组:7.5 μY±3.0 μV,患者组:4.5 μV±3.3 μV,P＜0.01)较健康对照组低.(2)ERN潜伏期和波幅变化与阳性症状分和PANSS总分之间缺乏显著性相关.(3)精神分裂症组脑岛、颞上回、颞中回、顶下小叶等处激活明显低下.结论(1)首发精神分裂症患者的ERN波幅和潜伏期异常,可能反映了本组患者内在错误监控机制存在缺陷,此特点仍需进一步随访.(2)脑岛等处功能异常导致的精神分裂症错误监控功能障碍,可能是其发病机制之一.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.