腹腔镜辅助经肛门改良Soave术治疗小儿先天性巨结肠的疗效及安全性分析

目的探讨腹腔镜辅助经肛门改良Soave术治疗小儿先天性巨结肠的临床效果。方法选取该院2013年4月‐2017年1月收治的先天性巨结肠患儿42例为研究对象,以随机数字表法将其分为观察组和对照组;观察组患儿给予腹腔镜辅助经肛门改良Soave术,对照组患儿给予单纯经肛门改良Soave术,观察两组患儿手术效果及术后并发症发生情况。结果观察组患儿术中出血量明显少于对照组患儿(P0.05);观察组患儿术后肛门排气时间和住院时间显著短于对照组患儿(P0.05);两组患儿手术时间比较差异无统计学意义(P0.05);观察组患儿术后3个月自主大便率为81.82%(18/22),略高于对照组患儿的75.00%(15/20)(P0.05);观察组患儿术后并发症发生率为4.55%(1/22),略低于对照组患儿的15.00%(3/20)(P0.05)。结论腹腔镜辅助经肛门改良Soave术治疗小儿先天性巨结肠疗效确切、术后恢复快且安全性高,值得临床推广。     

腹腔镜下经肛门改良Soave术Ⅰ期治疗小儿先天性巨结肠效果观察

目的 探讨腹腔镜下经肛门改良直肠黏膜剥除鞘内结肠拖出术（Soave）Ⅰ期治疗小儿先天性巨结肠（HD）的效果。方法 选择2019年1月—2020年12月利川市人民医院收治的HD患儿84例,随机分为2组各42例。对照组行开腹改良Soave术,观察组行腹腔镜下经肛门改良Soave术,比较2组临床指标、肛门功能[肛管高压区长度、肛管静息压（ARP）]、肠道菌群及并发症。结果 观察组手术时间、肠蠕动恢复时间、住院时间均短于对照组,术中出血量少于对照组,差异有统计学意义（P<0.05）。观察组术后大肠杆菌低于对照组,粪肠杆菌、乳酸杆菌、肛管高压区长度、ARP高于对照组,差异有统计学意义（P<0.05）。观察组并发症发生率低于对照组,差异有统计学意义（P<0.05）。结论在HD患儿中采用腹腔镜下改良Soave术Ⅰ期治疗效果较好,可缩短手术时间,减少术中出血量与术后并发症,改善肛门功能及肠道菌群。     

单纯经肛门Soave术及腹腔镜辅助治疗先天性巨结肠的临床研究

目的探讨单纯经肛门Soave术及腹腔镜辅助治疗先天性巨结肠患儿的临床价值。方法选择我院86例先天性巨结肠患儿随机分为观察组(行腹腔镜辅助Soave术)与对照组(单纯经肛门Soave术)各43例。对比两组手术相关指标,检测肛门静息压,采用Wingspread评分评估患儿肛门功能,并记录术后并发症发生率。结果观察组总手术时间长于对照组,术中出血量低于对照组(P0.05)。观察组切除病变肠管长度、肛门操作时间、术后住院时间均短于对照组(P0.05)。观察组术后3、6个月肛门静息压高于对照组(P0.05)。两组术后3、6、12个月肛门功能评分优良率比较,差异均无统计学意义(P0.05)。观察组并发症发生率低于对照组(P0.05)。结论相比于单纯经肛门Soave术,腹腔镜辅助Soave术术中出血少,肛门操作时间、术后住院时间均较短,对肛门功能损伤小,可降低术后并发症发生率。     

经肛门改良Soave术在小儿先天性巨结肠治疗中的效果研究

目的：探讨经肛门改良Soave术在小儿先天性巨结肠治疗中的临床效果。方法对该科收治的32例采用经肛门改良Soave术的先天性巨结肠患儿进行观察,并将同期收治的行传统Swenson手术的32例患儿作为对照组,比较两组在手术时间、术中出血量及术中、术后早期和晚期并发症的发生情况。结果观察组在手术时间、术中出血量和并发症均少于对照组,差异有统计学意义（P＜0.05）。结论经肛门改良Soave改良术治疗小儿先天性巨结肠安全有效,患儿排便的控制功能和生活质量明显提高,较传统Swenson改良法有明显优势,值得在临床推广。     

Ⅰ期经肛门改良Soave与经腹会阴根治术治疗小儿先天性巨结肠的对比研究

目的 探讨Ⅰ期经肛门改良Soave与经腹会阴根治术治疗小儿先天性巨结肠的临床效果与安全性。 方法 回顾性选取2014年10月-2017年8月收治的52例小儿先天性巨结肠患儿作为研究对象,根据手术方式分为观察组和对照组各26例,其中对照组患儿均进行传统经腹会阴根治术,观察组患儿均予以Ⅰ期经肛门改良Soave术。比较2组患儿手术一般情况如手术时间、术中出血量、胃肠功能恢复时间以及住院时间;比较2组患儿术后排便功能以及并发症情况;术后6个月对患儿进行随访以评价其生活质量和家长满意度。 结果 观察组患儿手术时间、术中出血量、胃肠功能恢复时间以及住院时间均明显短于对照组,差异均有统计学意义(P<0.05);观察组患儿术后排便功能以及并发症发生情况均显著优于对照组,差异均具有统计学意义(P<0.05);观察组患儿术后6个月的生活质量和家长满意度均显著优于对照组,差异具有统计学意义(P<0.05)。 结论 在治疗小儿先天性巨结肠的术式选择上,Ⅰ期经肛门改良Soave不仅较经腹会阴根治术临床效果更佳,患儿具有较好的术后恢复,生活质量也获得显著改善,家长满意度高,因此值得临床广泛推广与应用。      

不同手术方式治疗小儿先天性巨结肠的临床疗效比较

目的观察不同手术方式治疗小儿先天性巨结肠的疗效比较。方法选取2017年3月至2019年3月在郑州大学附属儿童医院接受手术的68例小儿先天性巨结肠患儿作为研究对象,采用随机数表法分为对照组与观察组,每组34例。对照组采用Duhamel根治术进行手术;观察组采用Ⅰ期肛门改良Soave术进行手术。比较两组患儿手术时间、术中出血量、肠鸣音出现时间、肛门排气时间及住院时间的差异;观察两组患儿术后7 d内并发症总发生率及术后第7天排便情况的差异。结果观察组患儿手术时间、术中出血量、肠鸣音出现时间、肛门排气时间及住院时间短于对照组,差异有统计学意义(P0.05)。观察组患儿术后7 d内并发症发生率低于对照组,差异无统计学意义(P0.05)。观察组患儿术后第7天排便情况优良率高于对照组,差异有统计学意义(P0.05)。结论Ⅰ期肛门改良Soave术总体疗效优于Duhamel根治术,患儿术后各项功能恢复快,安全性更好,且无需术后附加手术,有利于改善患儿预后。     

腹腔镜下行改良Soave术治疗新生儿先天性巨结肠临床分析

目的：研究改良Soave术借助腹腔镜治疗新生儿先天性巨结肠的临床疗效。方法选择该院2010年3月至2013年7月收治的68例先天性巨结肠新生儿,分为两组,试验组（34例）住院后经系统检查后行腹腔镜下改良Soave手术治疗,对照组（34例）给予传统手术治疗,观察术后疗效。结果术中出血量、手术时间以及疼痛视觉模拟评分（VAS ）比较,试验组效果均优于对照组（P＜0．05）;术后住院时间、肠蠕动恢复时间、禁食时间比较,试验组优于对照组（P＜0．05）。结论腹腔镜下行改良Soave术治疗新生儿先天性巨结肠具有较好的临床效果。     

经肛门Soave改良术和开腹根治术治疗先天性巨结肠疗效分析

目的观察经肛门Soave改良术和开腹根治术治疗小儿先天性巨结肠的疗效。方法 160例先天性巨结肠患儿中,80例接受经肛门Soave改良术（治疗组）,80例患者接受传统开腹根治手术（对照组）。分别对两组的手术时间、出血量、术后肠蠕动恢复时间、术后住院时间以及近期并发症进行分析,对患儿的肛门功能以及生活质量进行随访和问卷调查并评分。结果治疗组手术时间、手术出血量、住院时间以及肠功能恢复时间均低于对照组（P〈0.05）;治疗组术后并发症总发生率显著低于对照组（P〈0.05）。160例患儿经随访6个月～5年,治疗组患儿的肛门功能优良率以及生活质量优良率均明显高于对照组,差异有统计学意义（P〈0.05）。结论经肛门Soave改良术治疗小儿先天性巨结肠安全有效,且患儿排便控制功能和生活质量明显提高,值得临床推广使用。     

经肛门改良Soave术和经腹手术治疗先天性巨结肠疗效比较

目的 比较经肛门改良Soave术和经腹手术治疗先天性巨结肠的临床疗效.方法 选择2002年1月至2012年1月来我院住院治疗的54例先天性巨结肠患儿为研究对象,随机分为两组各27例,改良组予以经肛门改良Soave术,对照组予以经腹手术,比较两组术后并发症、排便功能及各项指标.结果 两组患者经治疗后均痊愈出院.改良组术后共出现2例并发症,占7.41％;对照组术后共出现8例并发症,占29.63％;经比较差异具有统计学意义(x2=4.418,P=0.036).改良组的完全自主大便率明显高于对照组,污粪率明显低于对照组,经比较差异均具有统计学意义(P＜0.05).改良组手术时间、胃肠功能恢复时间、住院时间均明显短于对照组,经比较差异均具有显著统计学意义(P＜0.01).结论 经肛门改良Soave术治疗先天性巨结肠较经腹手术具有术后并发症少、术后排便功能好、手术时间短、胃肠功能恢复快、住院时间短等特点,值得临床推广.     

腹腔镜辅助改良Soave术根治小儿先天性巨结肠的围手术期护理

目的对小儿先天性巨结肠应用腹腔镜辅助改良Soave术进行治疗,对其围手术期的护理体会进行分析探讨。方法将本院收治的160例小儿先天性巨结肠患者应用腹腔镜辅助改良Soave术进行治疗,并在手术全程给予有针对性、精心的护理措施。结果160例患儿在腹腔镜辅助下顺利完成手术,160例患儿术后随访6~24个月,无并发症发生。结论腹腔镜辅助改良Soave术根治小儿先天性巨结肠能够取得较理想的治疗效果,在手术全程给予有针对性的精心护理可保证治疗效果,值得在临床推广应用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Dr.Zhang Ren's Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.