玻璃体切除联合硅油填充术治疗糖尿病视网膜病变的临床疗效

目的 探讨玻璃体切除联合硅油填充术治疗糖尿病视网膜病变的临床疗效.方法 回顾性分析2014年4月至2020年4月本院收治的60例增殖性糖尿病视网膜病变患者(71只眼)的临床资料,比较玻璃体切除联合硅油填充手术前后患者视力情况、血糖水平及术后并发症发生情况.结果 术后,视力改善49只眼,改善率为69.01％;术后,患眼光感、手动及数指率均低于术前,且视力0.03～0.09,0.01～0.02,0.1～0.2及>0.2者占比均高于术前,差异有统计学意义(P<0.05).术后,患者2 h PBG、FBG及HbAlc水平均低于术前,差异有统计学意义(P<0.05).71只眼术中发生医源性裂孔3例(4.23％),术后发生视网膜脱落6例(8.45％)、眼出血15例(21.13％)、白内障1例(1.41％)、高眼压3例(4.23％),并发症发生率为39.44％.结论 为糖尿病视网膜病变患者行玻璃体切除联合硅油填充术治疗,疗效较好,能有效提高患者视力,改善患者血糖水平,且患者发生并发症较少.     

玻璃体视网膜手术联合硅油填充后带状角膜变性

目的探讨复杂性视网膜脱离经玻璃体视网膜手术联合硅油填充后,角膜带状变性的发生率和危险因素。方法对146例复杂性视网膜脱离行玻璃体视网膜手术联合硅油填充后的临床资料进行回顾性分析。结果146例中术后2年角膜带状变性的发生率为9.8%,其中外伤性视网膜脱离发生率为19.6%,其他4.2%,无晶体眼和有晶体眼术后角膜带状变性的发生率分别为16.0%及6.3%,硅油取出术前存在带状角膜变性,术后有和无带状角膜变性的发生率为82.35%及17.65%;增殖性玻璃体视网膜病变C和D级患者,术后发生带状角膜变性发生率为1.8%和12.5%。结论带状角膜变性是复杂性视网膜脱离手术联合硅油填充后的一个并发症,眼外伤、无晶体眼及严重的增殖性玻璃体视网膜病变是发生带状角膜变性的危险因素。     

硅油眼内填充治疗复杂性视网膜脱离

目的 观察硅油眼内填充治疗复杂性视网膜脱离的临床效果。方法 回顾性研究45例(46眼)复杂性视网膜脱离病例，视网膜脱离伴严重增殖性玻璃体视网膜病变23眼(D1级5眼，D2级6眼，D3级12眼)．其中6眼单纯巩膜扣带术后未复位，巨大裂孔4眼，伴巩膜后葡萄肿的黄斑裂孔4眼，糖尿病视网膜病变Ⅵ期6眼。眼外伤增殖性玻璃体视网膜病变致牵拉性视网膜脱离9眼。行闭合式玻璃体手术硅油眼内填充，联合巩膜扣带术治疗。结果 术后随访3～24个月，43眼获解剖复位，成功率93．5％。成功病例视力均有不同程度提高。术后并发症高眼压6眼，白内障5眼，硅油乳化1眼。结论 玻璃体手术眼内硅油填充治疗复杂性视网膜脱离可明显提高手术成功率，用5000cps以上的硅油可减少并发症发生。     

玻璃体切除治疗增殖性糖尿病视网膜病变

目的 :评价玻璃体切除术治疗增殖性糖尿病视网膜病变的效果。方法 :93例 (13 9只眼 )增殖性糖尿病视网膜病变病例均行玻璃体切除术 ,术后平均随访 (16.72± 8.5 3 )个月 ,对视力改善情况及手术失败的原因进行回顾性分析。结果 :98只眼 (70 5 0 % )视力得到提高 ,术后视力明显好于术前 (P <0 0 0 1) ;手术失败的主要原因是视网膜脱离和黄斑病变。结论 :玻璃体切除术是治疗增殖性糖尿病视网膜病变的有效方法。     

巩膜扣带联合注气术治疗玻璃体切除术后非增殖性视网膜脱离的临床分析

目的总结巩膜扣带联合玻璃体腔注气术治疗玻璃体切除术后非增殖性视网膜脱离的临床疗效。方法回顾性分析2007年1月至2011年12月收治的玻璃体切除术后非增殖性视网膜脱离7例患者,共7只眼行巩膜扣带联合玻璃体腔注气术。手术后随诊4～19个月,观察术后视网膜复位、术后视力恢复及并发症发生情况。结果所有7只眼治愈（100％）,7例患眼视网膜裂孔均封闭,视网膜复位。2眼术后发现裂孔周围冷冻瘢形成不理想,于术后5～10d眼内气体填充状态下补充眼底激光治疗后裂孔封闭。1眼于扣带术后37d发现另一象限周边视网膜小裂孔,局限视网膜脱离经再次巩膜扣带联合玻璃体腔内注气术后,视网膜完全复位,未发生其他并发症。结论巩膜扣带联合玻璃体腔注气术治疗玻璃体切除术后非增殖性视网膜脱离,可避免再次玻璃体切除手术对眼内结构损伤,有利于视功能较快恢复,具有安全、有效、易于操作等特点,可作为治疗玻璃体切除术后非增殖性视网膜脱离的术式之一。     

玻璃体腔注射康柏西普联合23G玻璃体切割手术治疗增生型糖尿病视网膜病变疗效观察

目的 观察玻璃体腔注射康柏西普联合23G玻璃体切割手术治疗增生型糖尿病视网膜病变的临床效果.方法 采用回顾性非随机临床对照研究收集2014年6月至2016年6月淮安市第二人民医院收治的增生型糖尿病视网膜病变(PDR)患者76例85眼,依据术前是否行康柏西普玻璃体腔注射将患者分为联合药物治疗组和单纯手术治疗组.联合药物治疗组41眼在玻璃体切除术前5~7 d行康柏西普玻璃体腔注药0.5 mg/0.05 mL;单纯手术治疗组44眼单纯行玻璃体切除手术.对比观察两组患者手术时间、医源性裂孔、术中出血、电凝止血、填充物类型、术后玻璃体再出血以及术后6个月时的最佳矫正视力等情况.结果 联合药物治疗组的平均手术用时、医源性裂孔发生率、术中出血、应用电凝止血频率、术中硅油填充率、术后玻璃体再出血发生率及术后最佳矫正视力分别为(70.55±23.08)min、12.20%、19.51%、17.07%、34.15%、4.88%、(0.374±0.211),单纯手术治疗组分别为(99.57±28.86)min、50.0%、65.91%、43.18%、65.91%、18.18%、(0.263±0.171),两组比较差异均有统计学意义(P<0.05).结论 玻璃体腔注射康柏西普联合23G玻璃体切割手术治疗增生型糖尿病视网膜病变,能缩短手术时间,减少手术中电凝及医源性视网膜裂孔的发生率,降低硅油填充率以及手术后玻璃体再积血发生率,最终提高患眼视力.     

玻璃体切除术治疗复杂性人工晶体眼裂孔性视网膜脱离的疗效

目的 探讨一期玻璃体切除术治疗复杂性人工晶体眼裂孔性视网膜脱离（pseudophakic retinal detachment,PRD）的疗效及术后视网膜再脱离的原因.方法 回顾性分析106例资料完整的复杂性PRD且行玻璃体切除作为首选手术的患者资料.结果 术后平均随访时间20.8个月.术后视网膜首次复位77例（72.6%）,最终复位104例（98.1%）.术后视网膜再脱离的原因主要是新裂孔出现和增殖性玻璃体视网膜病变（proliferative vitreoretinopathy,PVR）.术后视力＞0.3的63例（59.4%）,视力≥0.1的90例（84.9%）,与术前视力（＞0.3仅36例,＜0.1则53例）相比差异有显著性（P＜0.001）.手术主要并发症是术中医源性裂孔（7.5%）;术后PVR（14.2%）和黄斑前膜（23.6%）.结论 一期玻璃体切除治疗复杂性PRD能取得较好的解剖和功能效果,是一种行之有效的方法 .但值得注意的是应尽量避免术中医源性裂孔的发生,因为除术后PVR外,新裂孔出现已成为视网膜再脱离的另一个重要原因.     

玻璃体切割术后保留灌注液治疗增生型糖尿病视网膜病变Ⅵ期患者疗效分析

目的 观察玻璃体手术保留灌注液治疗增生型糖尿病视网膜病变(PDR)Ⅵ期的疗效及并发症.方法 对27例(33眼)行玻璃体手术单纯保留灌注液治疗的PDRⅥ期连续性病例进行回顾性分析,观察单纯保留灌注液治疗效果.结果 33眼中视力≥0.02者由术前的20眼(60.6%)增加到术后的29眼(87.9%),其中视力≥0.1者由术前的l6眼(48.8%)增加到术后的23眼(69.7%);视网膜在位眼数31眼(93.9%);白内障发生率为30.3%(10/33);术后玻璃体出血1眼(3.0%).结论 术前存在视网膜脱离但不存在视网膜裂孔的PDRⅥ期患者,玻璃体手术保留灌注液可获得良好预后.     

玻璃体切除术治疗玻璃体积血的临床观察

目的 观察玻璃体切割术治疗玻璃体积血的治疗效果.方法 回顾性分析玻璃体积血行玻璃体切割手术患者24例25眼,其中视网膜静脉阻塞7眼,糖尿病视网膜病变8眼,外伤性玻璃体积血9眼,高血压视网膜病变并发黄斑裂孔1眼,将术前术后视力进行比较,对手术效果及并发症进行总结.结果 原发病视网膜静脉阻塞者术后视力好于糖尿病视网膜病变(P=0.015)及眼外伤(P=0.009),差异均有统计学意义(P<0.017),平均手术时机为28.02±6.39天,自出血到手术的时间与术后视力无明显相关性(P=0.714).结论 玻璃体切割手术是有效的玻璃体积血的治疗方法.     

44例眼内异物伤显微玻璃体手术临床效果分析

目的评价玻璃体显微切除手术治疗眼内异物伤的效果。方法回顾性分析44例（46眼）经显微玻璃体切除手术联合其他技术治疗的伴眼内异物的穿通伤的病例资料，对比观察术前和术中裂孔发现的个数和视网膜脱离的眼数，术后视力的改变，一次取出异物的成功率，网膜的复位情况。结果术前发现视网膜裂孔48个，术中发现视网膜裂孔58个，给予光凝、冷凝处理；术前视网膜脱离15只眼，术中确认36只眼，其中异物周围视网膜局部的浅脱离28眼，视网膜全脱离6例，漏斗状脱离2例；术后视力不同程度的提高，一次取出异物的成功率为97.8％，视网膜的复位率为89.1％。结论显微玻璃体手术可成功地摘出眼内异物，更准确、直观地了解眼内的病变，及时处理，有效地防止继发性视网膜脱离等并发症。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.