共查询到19条相似文献,搜索用时 140 毫秒
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自制了3种键合型直链淀粉苯基氨基甲酸酯类(苯基氨基甲酸酯IAT、3-氯苯基氨基甲酸酯IAC、3,5-二甲基苯基氨基甲酸酯IAD)手性固定相,比较了3种固定相对6种手性化合物的手性识别能力,同时也将商品柱Chiralcel OD-H、Chiralcel AD-H对6种手性化合物的拆分结果进行了比较。实验结果表明:所合成的键合型手性固定相对样品托儿格碱、2-羟基-3-(2-萘氧基)丙基-2',3'-二甲基苯基硒醚和戊唑醇表现出更好的手性识别能力,并且直链淀粉衍生物苯环上引入吸电子基团或给电子基团对固定相手性识别能力均有明显的影响。 相似文献
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用偶联剂3-(环氧丙氧基)丙基三甲氧基硅烷(GPTMS)将手性螺旋聚3-(9-烷基芴-9-基)-1,2-环氧丙烷键合到硅胶表面上,制备成高效液相色谱手性固定相。将该类手性固定相应用于拆分外消旋体。研究发现,在该类手性固定相中,以聚3-(9-乙基-9-芴基)-1,2-环氧丙烷键合硅胶手性固定相拆分效果为最佳。而且,这类手性固定相应用于高效液相色谱,解决了以往单手性螺旋的聚甲基丙烯酸酯类作为手性固定相一直存在的溶剂问题。 相似文献
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纤维素-三(3,5-二甲基苯基氨基甲酸酯)对烯唑醇对映体的直接拆分 总被引:3,自引:2,他引:3
制备了纤维素-三(3,5-二甲基苯基氨基甲酸酯)手性固定相(CDMPC),以正己烷为流动相,添加异丙醇为改性剂,在高效液相色谱上实现了对烯唑醇光学异构体的直接拆分,探讨了改性剂的含量及色谱柱长对拆分效果的影响,从而优化了拆分条件。试验结果显示,流动相中异丙醇含量的减少有利于对映体的拆分,但保留增强;长色谱柱也有利于对映体的分离。使用两色谱柱串连,当流动相中正己烷与异丙醇的比例为95:5时可达到最佳分离效果,分离因子为1.17。 相似文献
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Cecilia Cagliero Barbara Sgorbini Chiara Cordero Erica Liberto Patrizia Rubiolo Carlo Bicchi 《Israel journal of chemistry》2016,56(11-12):925-939
This article deals with enantioselective gas chromatography (Es-GC) utilizing cyclodextrin derivatives as chiral stationary phases (CSPs) for chiral recognition in the flavour and fragrance field. It consists of two main parts. The first one concerns cyclodextrins and their use in Es-GC, and it deals with their introduction and evolution as CSPs in GC, together with some theoretical aspects involved with enantiomeric separation and their consequent influence on routine chiral recognition. The second part reports on the strategy of chiral recognition in routine analysis with cyclodextrin derivatives as CSP, illustrated with examples from the authors’ everyday experiences. This part describes how to identify enantiomers or to measure their excess or ratio determination in complex mixtures; in particular, it discusses the opportunities offered by multidimensional and fast GC techniques, the role of mass spectrometry, and the application of total analysis systems to chiral recognition. 相似文献
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Runqiang Liu Yijun Zhang Lianyang Bai Mingxian Huang Jun Chen Yuping Zhang 《International journal of molecular sciences》2014,15(4):6161-6168
A chiral selector of cellulose-2,3-bis(3,5-dimethylphenylcarbamate) (CBDMPC) was synthesized by reacting 3,5-dimethylphenyl isocyanate with microcrystalline cellulose dissolved in an ionic liquid of 1-allyl-3-methyl-imidazolium chloride (AMIMCl). The obtained chiral selector was effectively characterized by infrared spectroscopy, elemental analysis and 1H NMR. The selector was reacted with 3-aminopropylsilanized silica gel and the CBDMPC bonded chiral stationary phase (CSP) was obtained. Chromatographic evaluation of the prepared CSPs was conducted by high performance liquid chromatographic (HPLC) and baseline separation of three typical fungicides including hexaconazole, metalaxyl and myclobutanil was achieved using n-hexane/isopropanol as the mobile phase with a flow rate 1.0 mL/min. Experimental results also showed that AMIMCl could be recycled easily and reused in the preparation of CSPs as an effective reaction media. 相似文献
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以添加醇类和二乙胺的正己烷为流动相,考察了多糖类、酒石酸类和环糊精类手性固定相对西酞普兰外消旋体的拆分效果,优选合适的手性固定相、流动相和温度等色谱条件,在此基础上利用前沿色谱法测定了西酞普兰对映体的吸附等温线。优化的色谱操作条件为:Chiralpak AD-H柱为固定相,正己烷∶异丙醇∶二乙胺(95∶5∶0.1,体积比)为流动相,柱温35℃。西酞普兰对映体的吸附等温线为优惠型,采用Langmuir方程拟合,效果较好。本研究为模拟移动床(SMB)制备西酞普兰对映体提供重要的基础数据。 相似文献
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A polysaccharide‐immobilized chiral stationary phase (CSP) was prepared by the surface‐initiated atom transfer radical polymerization (SI‐ATRP), in pyridine, of cellulose 2,3‐bis(3,5‐dimethylphenylcarbamate), having a polymerizable vinyl group, on the surface of SiO2 support. The successful preparation of the CSP was confirmed via Fourier transform infrared spectroscopy, field‐emission scanning electron microscopy, X‐ray photoelectron spectroscopy, elemental analysis and thermal analysis. The chiral recognition ability of the prepared CSP was evaluated with high‐performance liquid chromatography using 10 racemates with various mobile phases of hexane/alcohol, hexane/tetrahydrofuran and hexane/chloroform. As a result, this CSP prepared using SI‐ATRP can be used in tetrahydrofuran and chloroform solutions as eluents. Copyright © 2011 Society of Chemical Industry 相似文献
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A novel chiral methacrylamide bearing perfluoropyrrolidino groups was synthesized. Perfluoro(2‐pyrrolidinopropionyl fluoride), the starting material, was prepared by electrochemical fluorination and resolved into enantiomeric derivatives by preparative high performance liquid chromatography (HPLC) performed with optically active 1‐phenethylamine as the diastereomeric counterpart. The polymethacrylamide was obtained by radical polymerization. A clear, colorless, tough film of the polymer was formed by the solution‐casting technique, which showed excellent water repulsion with a contact angle of water greater than 100°. Column packings prepared by the coating of silica gels with the optically active polymer showed potential as the chiral stationary phase for HPLC resolving racemic 1,1′‐bi‐2‐naphthol (separation factor = 1.56) with a hexane–isopropanol mixture as the eluent. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 83: 1443–1448, 2002 相似文献