Synthesis of chiral stationary phase via surface‐initiated atom transfer radical polymerization of vinylated cellulose 3,5‐dimethylphenylcarbamate |
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Authors: | In‐Ae Bae Jung‐Hyun Park Seong‐Ho Choi |
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Affiliation: | Department of Chemistry, BK 21 NanoBiosensor Research Team, Hannam University, Daejeon 305‐811, Republic of Korea |
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Abstract: | A polysaccharide‐immobilized chiral stationary phase (CSP) was prepared by the surface‐initiated atom transfer radical polymerization (SI‐ATRP), in pyridine, of cellulose 2,3‐bis(3,5‐dimethylphenylcarbamate), having a polymerizable vinyl group, on the surface of SiO2 support. The successful preparation of the CSP was confirmed via Fourier transform infrared spectroscopy, field‐emission scanning electron microscopy, X‐ray photoelectron spectroscopy, elemental analysis and thermal analysis. The chiral recognition ability of the prepared CSP was evaluated with high‐performance liquid chromatography using 10 racemates with various mobile phases of hexane/alcohol, hexane/tetrahydrofuran and hexane/chloroform. As a result, this CSP prepared using SI‐ATRP can be used in tetrahydrofuran and chloroform solutions as eluents. Copyright © 2011 Society of Chemical Industry |
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Keywords: | chiral stationary phase surface‐initiated atom transfer radical polymerization HPLC immobilization chiral recognition |
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