| 乙氧呋草黄对映体的手性拆分研究 |
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| 引用本文： | 王鹏,江树人,周志强,刘丹,刘丰茂.乙氧呋草黄对映体的手性拆分研究[J].化学世界,2004,45(11):581-582,580. |
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| 作者姓名： | 王鹏 江树人 周志强 刘丹 刘丰茂 |
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| 作者单位： | 中国农业大学理学院应用化学系,北京,100094;中国农业大学理学院应用化学系,北京,100094;中国农业大学理学院应用化学系,北京,100094;中国农业大学理学院应用化学系,北京,100094;中国农业大学理学院应用化学系,北京,100094 |
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| 摘 要： | 进行了除草剂乙氧呋草黄对映体在自制的纤维素-三(3,5-二甲基苯基氨基甲酸酯)(CDMPC)高效液相色谱手性柱上的拆分研究。使用了两种流动相体系:正己烷-异丙醇;石油醚-异丙醇,并分别考察了流动相中加入的极性改性剂对手性拆分的影响。试验结果显示,乙氧呋草黄在两种流动相体系中都能得到最好的拆分,但正己烷体系优于石油醚体系,流动相中的极性改性剂的含量减少有利于手性拆分。在正己烷流动相条件下考察了柱长、温度对手性拆分的影响。对对映体的拆分机理进行了讨论。
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| 关 键 词： | 乙氧呋草黄 手性固定相 拆分 |
| 文章编号： | 0367-6358(2004)11-0581-02 |
Study on the Chiral Separation of the Enantiomers Ethofumesate |
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| WANG Peng,JIANG Shu-ren,ZHOU Zhi-qiang,LIU Dan,LIU Feng-mao.Study on the Chiral Separation of the Enantiomers Ethofumesate[J].Chemical World,2004,45(11):581-582,580. |
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| Authors: | WANG Peng JIANG Shu-ren ZHOU Zhi-qiang LIU Dan LIU Feng-mao |
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| Abstract: | The direct separation of the two enantiomers of ethofumesate on the CDMPC chiral stationary phase of the high-performance liquid chromatograph was studied. Two mobile phases, n-hexane-isopropane and petroleum ether-isopropane, were used, and the effect of isopropane content was investigated. Satisfactory results were obtained in both systems. The influence of column length and temperature were also studied in n-hexane system. |
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| Keywords: | ethofumesate chiral stationary phase resolution HPLC |
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