正清风痛宁药物治疗的副作用及防治

目的:探讨正清风痛宁药物在风湿病治疗过程中的不良反应及防治方法。方法:总结归纳117例风湿病患者在服用正清风痛宁药物时出现的不良反应,探讨不良反应的影响因素。结果:正清风痛宁在治疗风湿病过程中存在一定副作用,与用药时间成反比,与用药剂量成正比。结论:应用正清风痛宁治疗风湿病过程中,需要把握其作用规律。     

氨基葡萄糖联合正清风痛宁缓释片治疗膝骨关节炎的临床观察

目的观察硫酸氨基葡萄糖联合正清风痛宁缓释片治疗膝骨关节炎的疗效。方法 63例膝骨性关节炎患者随机分为两组,观察组33例采用口服硫酸氨基葡萄糖胶囊联合正清风痛宁缓释片治疗,对照组30例口服双氯芬酸钠缓释片治疗,两组均6周1疗程,治疗前后测量并对比两组Lequesne指数,计算治疗有效率。结果治疗后氨基葡萄糖联合正清风痛宁组Lequesne指数的改善百分率、治疗有效率明显优于双氯芬酸钠组,两组比较差异有统计学意义(P0.05)。结论硫酸氨基葡萄糖联合正清风痛宁缓释片是治疗骨性关节炎的有效药物,值得临床推广应用。     

正清风痛宁治疗踝关节骨性关节炎的探讨

目的:观察正清风痛宁注射液关节腔内注射治疗踝关节骨性关节炎的临床疗效。方法:60例踝关节骨性关节炎患者,常规关节腔穿刺注入正清风痛宁注射液,隔天1次,每次1.2毫升,5针为1个疗程。一般观察3个疗程。疗程结束后,按照AOFAS踝~后足评分法评定踝关节疼痛,功能障碍等改善情况。结果:踝关节内注射正清风痛宁注射液治疗后,患者的疼痛、功能障碍等均有明显改善。疼痛评分提高15.1(P0.01),功能评分提高4.7(P0.05),总有效率90.3%。结论:正清风痛宁注射液对踝关节骨性关节炎是一种可供选择的安全有效的治疗药物。     

正清风痛宁治疗类风湿关节炎68例疗效观察

目的：观察正清风痛宁治疗类风湿关节炎（RA）的疗效。方法：口服正清风痛宁缓释片60rag,2次／d。结果：正清风痛宁治疗类风湿关节炎,总有效率达94．12％,不良反应率为8．82％。结论：正清风痛宁治疗RA疗效好,安全。     

关节腔内注射正清风痛宁治疗膝关节骨性关节炎158例

[目的]探讨正清风痛宁对骨性关节炎的治疗作用。[方法]膝关节骨性关节炎158例,使用正清风痛宁注射液2ml(50mg) 2%利多卡因1ml,行膝关节腔内注射,每日1次,连续5次为1个疗程。并抽取治疗前及2个疗程后关节液行免疫球蛋白检测。[结果]本组病例关节疼痛减轻的有效率为88.3%,关节压痛减轻的有效率为87.9%,关节活动障碍改善的有效率为88.1%。治疗前后免疫球蛋白经统计学处理,IgG、IgM有显著性差异。[结论]正清风痛宁注射对缓解骨性关节炎疼痛、肿胀、改善关节活动功能方面有明确疗效。     

正清风痛宁在强直性脊柱炎中的应用

“正清风痛宁”是由湖南正清制药集团股份有限公司研制生产,治疗风湿、类风湿性疾病及慢性肾炎的疗效显著、安全性好的系列中药制剂,有正清风痛宁缓释片、喜络明正清风痛宁片、正清风痛宁片和正清风痛宁注射液等多种剂型和规格,其主要成分为盐酸青藤碱。     

正清风痛宁缓释剂治疗类风湿关节炎临床效果研究

目的 探讨正清风痛宁缓释剂临床治疗类风湿关节炎效果.方法 选取我院2007年1～10月收治的40例类风湿关节炎患者,随即分成时照组和实验组,对照组给予甲氨蝶呤,实验组给予正清风痛宁缓释片.结果 两组患者的临床症状均有所改善,治疗组与对照组比较具有显著性差异.治疗组总有效率达80.0%.结论 正清风痛宁缓释剂具有较好的临床疗效.     

正清风痛宁关节内注射治疗强直性脊柱炎髋关节病变30例

目的:观察髋关节注射正清风痛宁注射液对强直性脊柱炎髋关节病变的疗效.方法:将2005年3月至2008年3月中国人民解放军广州军区广州总医院中医科门诊和病房治疗的强直性脊柱炎并伴有髋关节病变患者随机分成观察组(30例)和对照组(25例),观察组采用常规药物治疗,并采用正清风痛宁注射液髋关节注射,对照组采用常规药物治疗,比较治疗前和治疗后1个月的目测类比评分(visual analog scale, VAS)、Bath强直性脊柱炎功能指数(Bath ankylosing spondylitis functional index,BASFI)、Bath强直性脊柱炎疾病活动指数(Bath ankylosing spondylitis disease activity index, BASDAI)、血沉(erythrocyte sedimentation rate, ESR)、C反应蛋白(C-reactive protein, CRP).结果:两组患者治疗后VAS、BASFI、BASDAI、ESR和CRP均比治疗前显著降低(P<0.05),而且观察组VAS和BASFI的改善情况显著优于常规药物对照组(P<0.05).结论:常规药物治疗基础上联合应用正清风痛宁注射液治疗AS髋关节病变在改善患者局部疼痛和功能方面明显优于单纯常规药物治疗.     

电致孔脉冲仪配合正清风痛宁透皮给药治疗腰椎间盘突出症40例临床观察

目的观察正清风痛宁治疗腰椎间盘突出症的效果。方法电致孔脉冲仪配合正清风痛宁透皮给药治疗腰椎间盘突出症。结果1个疗程,治愈率100％,随访3—6月后,观察均无复发。结论正经风痛宁有祛风湿、通经络、止痹痛之功效,现代药理学研究表明,正清风痛宁还有活血化瘀,改善微循环和释放组织胺的作用。从而使病理产物清除,疼痛减轻,病情缓解。     

近10年来正清风痛宁治疗漏肩风病的研究进展

目的为了阐明正清风痛宁治疗漏肩风病的机理及临床疗效,同时也为临床更好地应用正清风痛宁治疗漏肩风病提供可靠并且有效的依据。方法通过检索中国知网、万方以及维普等全文数据库,以"正清风痛宁和漏肩风病/肩周炎/肩凝症/冻结肩"为检索式,以"篇名/主题词/关键词"为检索途径,检索了2007至2017年的相关文献,并对这些文献进行了归纳与总结。结果共检索到23篇文献,其中有关正清风痛宁的文献8篇,单独运用正清风痛宁治疗漏肩风病的文献6篇,正清风痛宁结合其他不同疗法治疗漏肩风病的文献9篇。结论正清风痛宁治疗漏肩风病是确实有效果的,值得临床上进一步推广及应用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.