红树伴生植物相思子的化学成分研究

目的 研究红树伴生植物相思子Abrus precatoriusL.茎叶的化学成分.方法 采用硅胶柱色谱、凝胶Sephadex LH-20柱色谱等手段对相思子茎叶的化学成分进行分离,应用光谱分析方法并结合文献对化合物进行结构鉴定.结果 从相思子茎叶中分离得到7个化合物,经鉴定分别为3-吲哚甲酸(1)、尿嘧啶(2)、N-[2-(1,3,4-三羟基-正二十烷基)]-正十六碳酰胺(3)、芒柄花素(4)、异亮氨酸(5)、豆甾-4,22-二烯-3β,6β-二醇(6)、△5.22豆甾醇-3-O-β-D吡喃葡萄糖苷(7).结论 化合物2～7首次从该植物中分离得到.     

相思子属药用植物研究新进展

相思子属（AbrusAdans）植物为多年生的草本或木本，共有12种，中国有其中的4种，即广东相思子（Abruscan—toniensis Hance）、毛相思子（Abrusmollis Hance）、相思子（AbrusprecatoriusLinn）和美丽相思子（Abruspulchellus Wall）。其中广东相思子的带根全草俗称鸡骨草，广泛用于黄疸以及急慢性肝炎等的治疗；毛相思子的带根全草称为毛鸡骨草，主治急慢性肝炎、肝硬化腹水、胃痛、风湿痹痛等症；相思子的干燥茎、叶又称相思藤，具有去湿化滞、益气生津、清热解毒、消炎利尿、润肺护肝等功效。     

相思子叶化学成分研究

目的对相思子（Abrus precatorius L．）叶进行成分分离和鉴别。方法利用溶剂提取法、萃取法和柱层析法对相思子叶化学成分进行分离,经理化性质和NMR、HRMS、HPLC—DAD等方法测定,分析并鉴定其结构。结果从相思子叶中分离并鉴别出5个化合物,分别为卢一谷甾醇（Ⅰ）、滨蓟黄苷（Ⅱ）、滨蓟黄素（Ⅲ）、相思子碱（Ⅳ）、下箴刺桐碱（Ⅴ）。结论Ⅱ、Ⅲ化合物为首次从该植物中得到。     

广东相思子的甜味三萜甙成分

广东相思子Abrus fruticulosus Wall. ex.W. & A 是豆科的一个仅有四种植物小属中的一个种,存在于非州和东南亚热带的不同地区,其根用于治疗消化不良。作者之一注意到其叶子在泰国中部用作传统药物甜味剂,因此进行了研究。虽然文献中已报道了这种     

高效液相色谱法测定鸡骨草胶囊中相思子碱的含量

目的 建立鸡骨草胶囊中相思子碱的含量测定方法.方法 采用反相高效液相色谱法测定鸡骨草胶囊中相思子碱的含量.色谱柱为Phenomenex-ODS(250 mm×4.0 mm,5 μm)柱;流动相为甲醇-0.5%(体积分数)冰乙酸溶液,梯度洗脱;流速为1.0 mL/min;检测波长为270 nm;温度为室温.结果 相思子碱...     

剧毒相思子不可误当赤小豆

含有强烈毒性的中药相思子误当赤小豆使用,古时有之,今仍有,应引起重视,防止中毒发生。相思子又名红豆、相思豆、黑头小鸡、鸡母珠,为豆科植物相思子的种子。形状椭园(少数近于球形),长5～7毫米,宽4～5毫米。上部朱红色,种脐部分黑色,有光泽。种皮坚硬,不易破碎。其气味如青草样,苦而涩。相思子根、茎、叶、花均有毒,以种子毒性最强,咀嚼后吞服0.5毫克即可中毒。现代医学已证实其毒为多种毒性蛋白,属细胞毒。中毒症状是:体温先升高而后降低,食欲不振,恶心呕吐,腹痛腹泻,呼吸困难,皮肤青紫,循环衰竭,出现蛋白尿,有时有抽搐,最后出     

治疗流行性腮腺炎验方一则

(1)药物组成相思子、鸡蛋清等二味组成。(2)制法及用法制法:相思子不拘分量,微火炒至黄色,研成细粉,备用。用法:用时以药粉加入适量蛋清,调成糊状软羔,涂布于塑料布或油纸上面敷贴患处,羔药面积要大子病灶部位,每天换药一次。(3)疗效1972年12月开始使用本方治疗流行性腮腺炎,共485例。除一例情况不明外,其余     

广州相思子保肝有效成分的研究

作为对豆科保肝植物研究的一部分,我们对广州相思子(Abrus cantoniensis)的活性成分进行了研究,它的干燥全草,在中国南方和东南亚用于治疗传染性肝炎。以大豆皂甙为对照,发现广州相思子的粗皂甙部分对CCl_4引起的肝损伤有预防作用,接着从粗皂甙的酸水解产物中得到8个新的齐墩果烷型三萜皂醇和已知的其它皂醇、槐二醇(sophora-diol)、大豆皂醇A、B和cantoniensistriol,这8个     

资料

1.相思子 Abrus Precatorius L.(豆科)。每日服用1杯其地上部分的水煎茶,可治疗糖尿病、高血压,也用于治疗痉挛和感冒。2.土牛膝 Achyranthes aspera L.(苋科)。其叶和茎的浸剂用于治疗膀胱疾病和感冒。3.藿香蓟 Ageratum conyzoides L.(菊科)。每日     

内容分析法在中医文献研究中的应用

目的:结合中医文献特征,简单介绍内容分析法的特征和流程,希望能对中医文献研究有所裨益.方法:本文从内容分析法的特征、流程等方面对内容分析法的基本研究方法和思路进行了概述.结果:内容分析法是一种对传播型资料进行客观、系统和定量描述的研究方法.目前在情报研究、读者研究、信息管理等方面已经得到了广泛的应用.在中医学研究中应用尚少.结论:在中医文献研究中借鉴内容分析法,对资料分析具有非常重要的意义.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Dr.Zhang Ren's Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.