黎族脑梗死ApoE基因多态性及饮食因素与血脂相关性研究

目的:探讨海南黎族脑梗死患者ApoE基因多态性及饮食因素与血脂的关系。方法:对受试者进行血脂检测,采用聚合酶链反应-限制性片段多态性方法检测ApoE基因多态性,并进行饮食因素调查,分析血脂异常与饮食因素及ApoE的关系。结果:共检测出6种基因型,ε4等位基因与TC、LDL-C正相关,ε2则为负相关;其TC、TG水平由高到低依次为嗜油食(嗜甜食(嗜吸烟(嗜饮酒(P(0.05),其中嗜素食、嗜槟榔者TC、TG无统计学意义(P(0.05)。结论:黎族脑梗死患者ApoE基因多态性与血脂水平显著相关,不同的饮食方式对血脂水平有一定影响。     

常州地区5200例健康体检成人血脂检测结果调查分析

目的对常州地区5200例健康体检成人血样进行甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）四项血脂指标检测分析,了解本地区健康体检成人血脂水平的现状。方法采集空腹血样测定血脂水平,统计检测结果,研究分析年龄、性别与血脂异常的关系。结果检出血脂异常共2441例,患病率为46.94%,其中男性血脂异常1447例,患病率为52.79%,女性血脂异常1059例,患病率为43.07%,男女两组TC、TG、HDL-C、LDL-C指标检测结果异常率比较均（P〈0.01）组间差异存在统计学意义。此外TG、TC、LDL-C均随年龄的增长而升高,且不同年龄组血脂水平比较（P〈0.05）组间差异存在统计学意义,但不同年龄组HDL-C指标比较（P〉0.05）组间差异无统计学意义。结论常州地区健康体检成人血脂异常患病率46.94%高于全国成人18.6%患病率水平,加强本地区目标人群血脂异常早期预防干预工作十分重要。     

广西三县痛风患者血脂水平及影响因素分析

目的 分析广西三县痛风患者的血脂水平现状及影响因素,为痛风疾病的治疗与预防提供参考依据.方法 采用1:1配对的病例-对照研究方法,在广西大化、三江县、合浦县开展相关研究,以2015年5月以县级及县级以上医院确诊的痛风病例作为痛风组(379例),病例选定后,根据痛风组病例的基本信息,在对应病例的同一社区/村屯选出所有与患者同性别、年龄相近、无血缘关系且居住的非痛风、非高尿酸血症者作为健康组(379例),共758例.收集研究对象的一般情况、体格检查、实验室检验等数据,并进行单因素和多因素的Logistic回归分析.结果 痛风组患者血脂异常检出率为57.5%,混合型血脂异常检出率为38.3%,痛风组与对照组间血脂异常、混合型血脂异常、高甘油三酯(TG)、高总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、血尿酸(UA)、TG、TC、HDL-C水平比较差异均有统计学意义(P<0.05);痛风组患者中的血脂正常组与异常组间UA、TG、TC、HDL-C、体重、BMI、腰围、收缩压、舒张压、血糖水平比较差异均有统计学意义(P<0.05);超重、肥胖、高尿酸、高血压是痛风患者高TG的主要影响因素(OR值分别为2.226、6.667、2.900、1.727);脂肪是高TC的主要影响因素(OR=1.093);超重、肥胖、高尿酸是血脂异常的主要影响因素(OR值分别为2.923、5.479、2.157);肥胖、高尿酸、高血压是混合型血脂异常的主要影响因素(OR值分别为4.052、2.257、1.649).结论 痛风患者的血脂异常率处于较高水平,对于痛风合并血脂异常的患者,应考虑血脂对痛风疾病的影响,改善血脂水平,达到治疗和预防痛风的目的.     

贵州省司法警察医院医务人员血脂异常的观察分析

目的通过血脂异常的观察,为健康教育和预防、干预提供依据.方法受检者为本院医务人员共300例,采用酶法测定血清总胆固醇(TC)、甘油三酯(TG).用PTA-Mg2 沉淀法,测定HDL-C(高密度脂蛋白胆固醇).结果检出血脂异常者52例,占总检人数17.3%.其中:男性96例,血脂异常21例,占21.9%.女性204例,血脂异常31例,占15.2%;52例中,28～40a年龄段4例,占血脂异常8%;41～60a 28例,占54%;60～73a 20例,占38%.TG增高36例,占69.2%,TC加DL-C增高12例,占23.1%,TG加TC加LDEC均增高4例,占7.7%.结论调查表明随着生活水平提高,饮食结构的不合理,缺乏运动的生活方式是造成血脂异常的重要原因,血脂异常是心脑血管疾病的危险因素,而定期检查血脂、早期干预是预防心脑疾病必要的手段和措施.     

鄂西州419例健康中老年人血脂调查报告

通过对本州419例健康中老年人进行血脂调查,结果表明,城镇人TC、TG水平较农民高,老年干部尤高;TC水平50岁以上各组均较40岁组高;TG水平,50岁组、60岁组较40岁组高,但70岁以上组与40岁组相似.其血脂增高总检出82例(占19.53%),男女之间,城镇人与农民之间均有差别.血脂增高在高血压、冠心病及糖尿病中检出率为29.25%(31人/106人),在无疾病者中检出率为16.29%(51人/313人).     

肥胖及血脂异常与2型糖尿病关系研究

目的:探讨肥胖及血脂异常与2型糖尿病的关系。方法:选取36例2型糖尿病患者作为观察组研究对象,另选取30例同期健康体检者作为对照组研究对象,测定BMI、WHtR、WHR及血脂水平,比较两组上述指标变化情况。结果:两组BMI、WHR、TC及TG比较有显著性差异(P0.05);WHtR、HDL及LDL比较无显著性差异(P0.05);观察组肥胖率为69.4%,高于对照组的40.0%,差异比较有统计学意义(P0.05);观察组高胆固醇及高甘油三酯检出率分别为27.8%及50.0%,高于对照组的6.7%及33.3%,差异比较有统计学意义(P0.05);体重指数及高胆固醇是糖尿病发生的危险因素。结论:肥胖及血脂异常与2型糖尿病密切相关,控制体重及合理膳食有助于预防2型糖尿病发生。     

体检人群性别和血胆红素与心血管危险因素的关系

目的 探讨不同性别体检人群血胆红素与心血管危险因素之间的关系.方法 采用横断面研究检测2458例常规体检者的身高、体重、血压、血胆红素、血糖、血脂和尿酸指标,同时行血管脉搏波(baPWV)测定.分别根据男女性血胆红素水平的四分位数,将人群分为4组(Q1、Q2、Q3和Q4组).不同分组心血管危险因素水平的比较采用ANOVA检验和x2检验.Spearman相关分析不同血胆红素水平与心血管危险因素的关系.采用Logistic回归模型进行多因素分析.结果 男性和女性甘油三酯均随血胆红素水平增高而降低(P＜0.05);高密度脂蛋白-胆固醇随血胆红素水平增高而增高(P＜0.05).女性BMI随血胆红素增高而显著降低(P＜0.05).男性高TG、低HDL-C及血脂异常的检出率随胆红素增高而降低;女性低HDL-C、血脂异常和超重的检出率随胆红素增高而降低,差异有统计学意义(P＜0.05).相关分析显示女性FPG、TC、TG、LDL-C和BMI均与胆红素水平显著负相关,HDL-C与胆红素显著正相关.男性仅TG与胆红素显著负相关,其它各因素未见明显相关性.Logistic回归分析结果显示,女性高血压和低HDL-C是高胆红素的危险因素.结论 女性体检者中血胆红素与心血管危险因素密切相关,可为心血管疾病治疗和预防提供参考.     

北京市体检人群血尿酸增高率及相关因素分析

目的分析北京市健康体检人群血尿酸增高检出率及相关危险因素。方法对2008年至2012年258 452例健康体检者的血尿酸增高的分布情况进行分析,并抽取2012年66 333例健康体检者的血尿酸、体质量、血脂、血压和血糖资料进行分析,按血尿酸值分为尿酸增高组和尿酸正常组,比较不同年龄段两组体质量、血脂、血压和血糖异常检出率。结果北京市体检人群尿酸增高率男性为21.8%~27.2%,女性为5.5%~7.9%。男女比较差异有统计学意义(P<0.05)。尿酸增高组的超重肥胖、血脂异常、血压增高和血糖升高检出率均高于尿酸正常组,两组比较差异有统计学意义(P<0.05)。多因素Logistic回归分析显示超重肥胖、血脂异常、血压增高和血糖升高是尿酸增高的危险因素。结论北京市健康体检人群的男性尿酸增高的检出率较高,年轻女性尿酸增高检出率逐年攀升,应加强尿酸增高人群的健康管理工作,以有利于疾病的早期发现与诊治。     

17 435名健康体检人群血脂水平分类及分型的统计分析

目的 分析体检人群血脂水平分类及分型特征.方法 收集2006年到柳州市人民医院进行健康体检人群17 435例的血脂资料,按我国"血脂异常防治建议"并参考美国"ATPⅢ"作血脂水平分类及分型研究.结果 ①总胆固醇(TC)水平:6个年龄组超过正常者均在33%以下,老年女性高达45%,16%可诊断为高脂血症;②甘油三脂(TG)的分布:在0.56 mmol/L以下者(除女性青年组外)均在6%以下;在1.69 mmol/L以上者,除女性青年前、后期及中年组外,其他各组均在27%以上,女性老年后期组更高达60.61%;大于2.26 mmol/L以上者占15%:③人群TC、TG均在正常范围者青年组65%、中年组50%、老年组40%;高脂血症患者随年龄的增加而增多.男性TG的增高略多于TC的增高,女性则TC的增高略多于TG的增高;④高密度脂蛋白胆固醇(HDL-C):低HDL-C的分布频率在男性随年龄增长而增多,老年前、中、后组均达30%以上;女性老年中、后期明显增多,达20%以上.高LDL-C的分布频率各组(除男性中年组和女性老年组外)均未超15%.结论 柳州市健康体检人群血脂异常处于一个较高水平(异常者达50%),并且有年轻化的趋势(青年人达到了40%).     

血生化检验中血液胆固醇异常与载脂蛋白B代谢缺陷的相关性

目的:探讨血生化检验中血液胆固醇异常与载脂蛋白B(ApoB)代谢缺陷的相关性。方法:选取2015年6月-2017年6月于本院进行体检的795例健康体检者为对照组、281例血脂异常患者为观察组。两组均进行血糖指标(FBG、2 h PBG)、血液胆固醇指标(TG、TC、LDL-C、HDL-C)、ApoB水平检测并进行比较,分析ApoB与血糖、胆固醇指标间的相关性。结果:继发性血脂水平异常患者占比87.90%,明显高于原发性血脂水平异常患者的12.10%,比较差异有统计学意义(P0.05);观察组FBG、2 h PBG、TG、TC、LDL-C、ApoB水平均明显高于对照组,HDL-C水平明显低于对照组,比较差异均有统计学意义(P0.05);Pearson分析显示,ApoB与FBG、2 h PBG、TG、TC、LDL-C水平均呈正相关(P0.05),与HDL-C呈负相关(P0.05)。结论:血脂异常患者以继发性为多见,血脂异常患者FBG、2 h PBG、TG、TC、LDL-C、HDL-C等指标水平有异于健康人群,ApoB的代谢缺陷与血液胆固醇异常具有密切的关系,在临床上通过对ApoB的检测可以为高脂血症患者的诊断、治疗及预后提供可靠的参考价值。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.