诱导期应用右旋美托咪啶对小儿全麻苏醒质量的影响

目的探讨诱导期应用右旋美托咪啶(Dex)对小儿全麻苏醒质量的影响。方法气管内插管全麻患儿40例,随机分为右美托咪啶组(Dex组)和对照组(Con组)各20例。Dex组10 min持续静脉泵入Dex 1.0μg/kg,Con组以生理盐水作为对照。随后2组患儿均依次静脉滴注芬太尼4μg/kg、丙泊酚2 mg/kg及罗库溴铵0.6 mg/kg进行麻醉诱导及气管插管通气。术中吸入2.5%七氟醚,间断静脉推注丙泊酚以维持麻醉。观测泵注Dex前(T_1)、泵注Dex后10 min(T_2)、20 min(T_3)、30 min(T_4)以及拔管时(T_5)的心率(HR)、平均动脉压(MAP)。计算停止麻醉药物后的拔管时间和睁眼时间,对苏醒期躁动程度及疼痛程度进行评分,计算患儿躁动评分≥3分的发生率及丙泊酚的用量。结果与T_1时比较,Dex组在T_2时MAP升高且高于Con组,T_4时HR降低(P<0.05)。与Con组比较,Dex组T_4时MAP和HR均降低(P<0.05)。2组拔管时间和睁眼时间比较差异均无统计学意义(P>0.05)。Dex组躁动发生率、躁动评分、疼痛评分及丙泊酚用量均较Con组显著降低(P<0.05)。2组患儿术后均无支气管痉挛、呼吸抑制等不良反应。结论尽管诱导期Dex 1.0μg/kg会对患儿MAP和HR有一过性影响,但不影响拔管时间和睁眼时间,可以显著降低七氟醚麻醉后术后躁动的发生率,此外术后即刻疼痛评分也显著下降,使患者苏醒期更加平稳。     

右美托咪定对老年患者食管癌手术全麻苏醒期躁动及寒战的影响

目的:探讨右美托咪定预防老年患者食管癌手术全麻苏醒期躁动及寒战的作用。方法:80例ASAⅠ～Ⅲ级择期行全麻食管癌手术的老年患者,随机分为右美托咪定组(D组)和对照组(C组),D组患者麻醉诱导插管前静脉泵注右美托咪定0.4μg/kg(泵注时间为15 min),然后以0.1μg/(kg·h)的速度持续静脉输注至手术结束前40 min,C组患者以相同的方式予以生理盐水。按照设定的时间记录患者麻醉期间血流动力学指标,观察两组患者苏醒时间、拔管时间、麻醉后监测治疗室(PACU)停留时间以及患者苏醒期的躁动行为、寒战情况和拔管时Ramesay镇静评分。结果:与C组比较,D组苏醒期躁动与寒战发生率减少(P<0.01),D组拔管时间略长于C组(P<0.01),但D组患者PACU停留时间短于C组患者(P<0.05),Ramesay镇静评分也稍高于C组(P<0.01)。与C组比较,D组术中麻醉镇痛药物瑞芬太尼的使用量减少(P<0.05)。D组患者HR和MAP在插管即刻(T3)均低于C组患者(P<0.01)。结论:右美托咪定可以有效预防老年患者全麻食管癌手术苏醒期躁动及寒战,并缩短患者PACU停留时间,改善患者麻醉苏醒质量。     

瑞芬太尼与右美托咪定用于后路腰椎椎体融合术患者全麻气管拔管反应的影响

目的观察瑞芬太尼与右美托咪定对后路腰椎椎体融合术手术(PLIF)患者全麻气管拔管期的影响。方法择期行后路腰椎椎体融合术患者90例,ASA I~Ⅱ级,随机分为三组,瑞芬太尼组、右美托咪定组和对照组,每组30例,均采用静吸复合全麻。三组患者麻醉全麻诱导均采用咪达唑仑0.05mg/kg、丙泊酚2mg/kg、芬太尼4μg/kg和罗库溴铵0.6mg/kg,麻醉维持均采用七氟烷1.1~1.4MAC和丙泊酚4~6mg/(kg·h)维持。术毕瑞芬太尼组患者持续泵注瑞芬太尼0.1μg/(kg·min),右美托咪定组患者持续泵注右美托咪定0.5μg/kg,对照组患者则持续泵注等容量0.9%生理盐水,均直至气管拔管后停止,观察麻醉前(T0)、给药前1分钟(T1)、拔管时(T2)、拔管后5分钟(T3)和拔管后10分钟(T4)时间点患者的平均动脉压(MAP)和心率(HR),记录各组患者清醒时间、拔管时间和定向力恢复时间,同时记录拔管期间不良反应的发生情况。结果瑞芬太尼组和右美托咪定组在T2~T3时点的MAP和HR较T0显著降低(P<0.05);瑞芬太尼组和右美托咪定组患者在不同时点MAP和HR比较差异无统计学意义(P>0.05);瑞芬太尼组气管拔管时间要短于右美托咪定组(P<0.05),瑞芬太尼组、右美托咪定组和对照组患者清醒时间和定向力恢复时间比较无统计学差异(P>0.05);对照组患者拔管后躁动、呛咳的发生率明显高于瑞芬太尼组和右美托咪定组(P<0.05)。结论瑞芬太尼与右美托咪定均可为后路腰椎椎体融合术患者术后苏醒期提供安全有效的气管拔管条件,减少应激反应。但使用瑞芬太尼术后拔管时间更短,在临床应用更具优势。     

右美托咪定对小儿全麻苏醒期的影响

目的 观察右美托咪定预防小儿全麻苏醒期躁动的效果.方法 选择ASA分级Ⅰ～Ⅱ级在丙泊酚复合瑞芬太尼静脉全麻行腹股沟疝行常规手术的患儿60例.随机分为对照组(C组)和右美托咪定(D组)组各30例,麻醉前对照组注射生理盐水10mL,右美托咪定组注射右美托咪定0.5μg/kg,两组患儿静脉注射瑞芬太尼0.5μg/kg和丙泊酚2mg/kg麻醉诱导,麻醉维持采用静脉输注丙泊酚5mg/kg·h和瑞芬太尼0.2μ g/kg·min,在手术结束前15min静脉注射芬太尼0.1μ g/kg.记录小儿苏醒时(T0)、小儿苏醒后10 min(T1)、小儿苏醒后30 min(T2)、小儿苏醒后60 min(T3)的HR、Sp02.记录小儿苏醒时间、躁动评分及躁动例数.结果 两组小儿苏醒后各时间点Sp02比较无统计学意义,但苏醒后各时间点右美托咪定组患儿的HR比对照组低,比较具有统计学意义.D组比C组的苏醒时间延长,具有统计学意义.美托咪定组患儿躁动评分比对照组低,两组间比较有统计学意义,躁动例数D组比C组明显少比较,比较有统计学意义(P＜0.05).结论 术前静脉注射右美托咪定0.5μg/kg能有效预防小儿全麻术后躁动,且没有呼吸抑制作用,是预防小儿全麻术后躁动的一个很好选择.     

美托咪啶用于全身麻醉临床观察

目的:探讨右旋美托咪定(Dex)对全麻患者麻醉药用量、对气管插管和拔管引起的应激反应的抑制作用以及对麻醉恢复期的影响。方法:选择60例择期手术全麻患者(ASAⅠ～Ⅱ级),将患者随机分成Dex组和对照组,每组各30例。Dex组将右旋美托咪定稀释成4μg/kg并以负荷量1.0μg/kg在全麻诱导前15分钟缓慢静脉泵注,对照组静脉泵注等容量生理盐水。全麻诱导时使用丙泊酚2mg/kg、芬太尼2μg/kg、维库溴铵0.15mg/kg静注。4分钟后进行气管内插管。插管成功后吸入七氟醚。Dex组静脉泵注右旋美托咪定0.5μg/(kg·小时)至手术结束,对照组静脉泵注同等容量的生理盐水。手术结束时停用七氟醚,记录患者丙泊酚诱导量(mg/kg)和芬太尼总用量,记录患者入室时(T0)、插管时(T1)、手术后睁眼时(T2)、拔管时(T3)、拔管后10分钟(T4)的HR、平均动脉压(MAP),记录术后呼吸恢复时间、睁眼时间和拔管时间及麻醉恢复期寒颤发生例数。结果:与对照组比较,Dex组的丙泊酚诱导量和芬太尼总用量明显减少(P<0.01)。对照组在T1、T3的MAP、HR与基础值T0比较明显升高(P<0.01),Dex组T1～T4的MAP、HR与基础值T0比较则无明显变化;Dex组在T1、T3的MAP、HR与对照组比较明显降低(P<0.01)。与对照组比较,Dex组术后麻醉恢复期寒颤发生率明显减少(P<0.01)。结论:右旋美托咪啶具有镇静、抗焦虑、镇痛、抗交感、降低应激反应、稳定血液动力学的作用,美托咪啶用于全身麻醉可明显减少麻醉剂用量;减少寒战的发生,降低围术期心肌缺血的发生。     

右美托咪定对神经外科术后患者全麻苏醒期躁动的临床研究

目的 探讨右美托咪定对神经外科术后患者全麻苏醒期躁动的影响.方法 选择行颅脑外科手术患者60例,采用随机数字表法将其均分为右美托咪定组(Dex组)和对照组,各30例,Dex组围手术期给予右美托咪定,对照组给予等容量0.9%氯化钠溶液,观察比较两组患者不同时刻的心率(HR)、平均动脉压(MAP)、血氧饱和度(SpO2)的变化及躁动的发生情况;并比较SAS评分及Ramsay评分差别.结果 Dex组拔管即刻和拔管后5 min时MAP比对照组低,HR明显减慢,差异均有统计学意义(P<0.05),两组患者SpO2比较差异无统计学意义;Dex组患者躁动评分和躁动发生率显著低于对照组(P<0.05);拔管时,Dex组患者SAS评分比对照组低,差异有统计学意义(P<0.05);拔管后10 min,Dex组患者Ramsay评分比对照组高,差异有统计学意义(P<0.05).结论 采用右美托咪定有利于全麻患者维持血流动力学稳定,缓解拔管时及把关后患者躁动情况,减少神经外科手术患者全麻苏醒期躁动的发生,值得进一步研究.     

右美托咪定复合丙泊酚全麻对骨科腰椎手术患者术后恢复的影响

目的：评价右美托咪定（dexmedetomidine,DEX）复合丙泊酚全麻对骨科腰椎手术患者术后恢复的影响。方法：选择北京大学第一医院2014年1月至5月择期全麻下行腰椎管减压、椎弓根钉内固定植骨融合术患者60例,美国麻醉医师协会（American Society of Anesthesiologists,ASA）分级Ⅰ～Ⅱ级,年龄18～65岁,按随机数字表将患者分为DEX组和对照组,每组30例。两组患者均以咪达唑仑0.03 mg/kg、丙泊酚1～2 mg/kg、舒芬太尼效应室靶控浓度0.5 μg/L和顺式阿曲库铵0.2 mg/kg诱导插管,术中以吸入50%（体积分数）笑气、靶控输注丙泊酚和舒芬太尼维持麻醉。DEX组麻醉诱导前静脉泵入DEX 0.5 μg/kg（10 min）,术中以0.2 μg/(kg·h)持续输注;对照组静脉泵入等量生理盐水。两组术后均采用0.5 g/L吗啡静脉自控镇痛,记录两组患者麻醉诱导、术后拔管及恢复时的平均动脉压（mean arterial pressure,MAP）、心率（heart rate,HR）, 术毕停药后的苏醒时间、拔管时间和定向力恢复时间,术后1 h在麻醉后恢复室（post-anesthesia care unit,PACU）的Ramsay评分和苏醒期躁动RSAS评分,术后48 h内的疼痛视觉模拟评分（visual analogue scale,VAS）、自控镇痛吗啡用量及不良反应发生率。结果：两组患者术后苏醒时间、拔管时间和定向力恢复时间差异均无统计学意义。两组患者PACU停留期间的Ramsay评分及苏醒期躁动RSAS评分差异均无统计学意义。DEX组术后48 h内各时点的VAS评分均显著低于对照组（P<0.05）,术后2 h和6 h的吗啡累计用量小于对照组（P<0.05）。与对照组比较,DEX组于DEX负荷量输注结束时HR显著减慢,MAP明显降低（P<0.05）,于诱导插管、术后拔管各时点及PACU 10 min时HR显著减慢（P<0.05）,于术后拔管各时点和PACU期间MAP显著降低（P<0.05）。与对照组相比,DEX组于DEX输注结束时HR和MAP均显著降低。DEX组于术中诱导插管开始至拔管后各时点及PACU停留10 min时的HR显著低于对照组（P<0.05）;在拔管后各时点及PACU期间,DEX组的MAP显著低于对照组（P<0.05）。结论：DEX复合丙泊酚全麻用于骨科腰椎手术时,可改善术后镇痛效果,节俭术后早期吗啡用量,并减少术后恶心和呕吐发生率。     

氟比洛芬酯联合右美托咪定抑制全麻苏醒期躁动的效果观察

目的：探讨氟比洛芬酯复合右美托咪定全身麻醉后,对抑制苏醒期躁动的有效性.方法：择期手术患者80例,随机分为2组（n=40）.F组：术前10min氟比洛芬酯1mg/kg静注;FD组：术前10min氟比洛芬酯1mg/kg＋术毕前5min给予右美托咪定0.5μg/kg缓慢静注.记录患者基础（T0）、拔管前1min（T1）、拔管后1min（T2）、拔管后5 min（T3）、拔管后10min（T4）的HR、MAP值并评估患者T3、T4的Ramsay镇静（RSS）评分和VAS疼痛评分,记录患者苏醒、拔管时间.结果：T1 ～T4时间点,FD组HR、MAP升高幅度均显著小于F组（均P＜0.05）.RSS评分：T3、T4时间点,F组与FD组相比评分显著降低（P＜0.05）.VAS评分：F组与FD组相比评分显著升高（P＜0.05）.唤醒、拔管时间方面2组相比差异无统计学意义（均P＞0.05）.结论：术前10min给予氟比洛芬酯1mg/kg＋术毕前5min给予右美托咪定0.5μ g/kg,可有效降低术后躁动且不影响苏醒、拔管时间.     

右美托咪啶预防长时间全麻下腹部手术患者术后 苏醒期寒战的临床效果

目的 分析右美托咪啶预防长时间全麻下腹部手术患者术后苏醒期寒战的临床效果.方法 选取收治的102例长时间全麻下腹部手术患者作为本次研究的对象,随机将患者分为右美托咪啶组和生理盐水组,各51例.给予右美托咪啶组患者应用右美托咪啶预防苏醒期寒战,生理盐水组患者则应用生理盐水预防苏醒期寒战.对两组患者拔管前、拔管后10 min的寒战分级情况进行对比分析.结果 右美托咪啶组患者在拔管前和拔管后10 min中的寒战分级情况均显著优于生理盐水组,差异有统计学意义(P<0.05).结论 右美托咪啶预防长时间全麻下腹部手术患者术后苏醒期寒战具有良好的临床效果.     

右美托咪啶和丙泊酚用于宫腔镜检查术的效应比较

目的：观察右美托咪啶、丙泊酚分别用于宫腔镜检查术的临床效果及安全性。方法选择宫腔镜检查术适应证患者80例,随机分为右美托咪啶组（ A组）和丙泊酚组（ B 组）,每组40例。A 组以1μg／kg剂量右美托咪啶缓慢静注,10 min后以0.2~0.6μg／（kg·h）维持;B 组以1.5 mg／kg 剂量丙泊酚静脉注射后以4~6 mg／（kg·h）维持,镇静目标维持Ramsay镇静评分3~4分。分别记录麻醉前（T0）、麻醉诱导后2 min（T1）、扩宫颈时（T2）、手术结束时（T3）、苏醒时（T4）患者的平均动脉压（MAP）、心率（HR）、血氧饱和度（SpO2）、呼吸频率（RR）;记录患者的术后睁眼时间、定向力恢复时间及呼吸抑制（ SpO2＜93%或呼吸暂停＞15 s）的发生率;并记录患者宫腔镜手术后宫缩痛的发生情况及严重程度。结果麻醉诱导后2 min、扩宫颈时、膨胀宫腔后1 min 丙泊酚组的MAP、SpO2低于右美托咪啶组,RR慢于右美托咪啶组（P ＜0.05）;手术结束时丙泊酚组 MAP 高于右美托咪啶组（P＜0.05）。丙泊酚组睁眼时间和定向力恢复时间明显长于右美托咪啶组（P＜0.05）,呼吸抑制发生率高于右美托咪啶组（P＜0.05）。丙泊酚组术后宫缩痛重于右美托咪啶组（P＜0.05）。结论右美托咪啶较丙泊酚静脉麻醉镇痛效果更好,宫缩痛少而轻,苏醒及定向力恢复快,无呼吸抑制,且血流动力学更平稳。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.