东莨菪碱对兔主动脉条收缩反应的影响

用离体兔胸主动脉条研究东莨菪碱（ｓｃｏｐｏｌａｍｉｎｅ，Ｓｃｏｐ）扩张血管作用的可能机理。Ｓｃｏｐ与维拉帕米对ＣａＣｌ２和Ｓｃｏｐ对ＫＣＩ所致兔胸主动脉条收缩的量－效曲线右移，最大反应降低，呈现非竞争性拮抗，其ｐＤ＇２分别为３．４，５．８和３．４。两药能明显抑制ＮＥ的依赖内Ｃａ（２＋）性收缩，Ｓｃｏｐ对ＮＥ的依赖外Ｃａ（２＋）性收缩几无影响，表明Ｓｃｏｐ可能主要作用于电压依赖性的钙通道，阻断Ｃａ（２＋）内流。     

肝性脑病大鼠海马CA1区锥体细胞氨基酸激活电流改变

探讨氨基酸受体门控性离子通道电流改变在肝性脑病（ＨＥ）发生中的作用。方法用快速加药装置将５０μｍｏｌ／Ｌγ－氨基丁酸（ＧＡＢＡ）或１ｍｍｏｌ／ＬＮ－甲基－Ｄ－天冬氨酸（ＮＭＤＡ）＋１０μｍｏｌ／Ｌ甘氨酸（Ｇｌｙ）加于急性分离的大白鼠海马ＣＡ１区锥体细胞周围，用全细胞膜片钳技术记录ＧＡＢＡ或ＮＭＤＡ激活的电流。结果ＨＥ大鼠海马ＣＡ１区锥体细胞ＧＡＢＡ激活的内向电流的强度为４１３．３±４３６．８ｐＡ（３１例），比对照大鼠（２３３．４±１７９．７ｐＡ，２８例）有较大增强（ｔ＝２．１０４９，Ｐ＜０．０５）。并观察到ＨＥ大鼠ＧＡＢＡ激活电流的出现频率较对照大鼠高。ＨＥ大鼠ＮＭＤＡ激活的内向电流的强度为４０８．５±３１７．２ｐＡ（３７例），比对照大鼠（８８２．６±８９６．５ｐＡ，２６例）弱（ｔ＝２．５８５１，Ｐ＜０．０５）。两组大鼠ＮＭＤＡ激活电流的出现频率无明显差异。结论氨基酸受体门控性离子通道电流改变在肝性脑病发生中起一定作用。     

萘甲异喹对离体豚鼠回肠平滑肌的作用

研究萘甲异喹（ＮＩ）对离体豚鼠回肠平滑肌的作用。ＮＩ（１０、３０μｍｏｌ／Ｌ）可明显抑制离体豚鼠回肠的自发性收缩，能拮抗组胺、乙酰胆碱和５－羟色胺对回肠的收缩效应，表现为非竞争性拮抗，其ｐＤ＇２分别为５．３６±０．４９、４．７４±０．３２和４．８１±０．５１。ＮＩ（１０、３０μｍｏｌ／Ｌ）尚能抑制ＣａＣｌ２和ＢａＣｌ２引起的离体豚鼠回肠收缩，并可抑制组胺引起肠组织内Ｃａ２＋浓度升高。结果提示：ＮＩ能抑制肠平滑肌细胞外Ｃａ２＋内流及细胞内Ｃａ２＋释放引起的平滑肌收缩，可能是一非特异性钙拮抗剂。     

非胰岛素依赖型糖尿病患者红细胞膜ATPase活性改变及其影响因素

目的探讨非胰岛素依赖型糖尿病（ＮＩＤＤＭ）患者红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ及Ｃａ２＋－ＡＴ－Ｐａｓｅ活性改变的影响因素。方法测定７７例ＮＩＤＤＭ患者和５０例正常人血糖、总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、高密度脂蛋白胆固醇（ＨＤＬＣ）、脂质过氧化物（ＬＰＯ）、谷胱甘肽（ＧＳＨ）、糖化血红蛋白（ＨｂＡｌｃ）、超氧化物歧化酶（ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨＰＸ）、红细胞膜Ｎａ＋－Ｋ＋－ＡＴ－Ｐａｓｅ和Ｃａ２＋－ＡＴＰａｓｅ活性。ｔ检验、直线相关分析和多元逐步回归分析。结果ＮＩＤＤＭ组血糖、ＨｂＡｌｃ、ＴＣ、ＴＧ、ＴＣ／ＨＤＬＣ、ＬＰＯ显著高于对照组（Ｐ＜０．０１），ＨＤＬＣ、ＧＳＨ、ＳＯＤ、ＧＳＨＰＸ、红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ和Ｃａ２＋－ＡＴＰａｓｅ活性低于对照组（除ＧＳＨ的Ｐ＜０．０５外，其他Ｐ＜０．０１）；不同ＨｂＡｌｃ、ＴＣ／ＨＤＬＣ、ＧＳＨ、ＬＰＯ、ＴＣ组的红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ活性有显著性差别。红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ活性＝１２．８０＋０．２７（ＧＳＨ）－０．１２（ＬＰＯ）－０．０９（ＴＣ／ＨＤＬＣ），红细胞胞膜Ｃａ２＋－ＡＴＰａｓｅ活性＝１０８．２０＋１．     

乙型肝炎病毒x蛋白对细胞周期的影响

目的　研究乙型肝炎病毒ｘ（ Ｈ Ｂｘ） 蛋白对细胞周期影响,探讨 Ｈ Ｂｘ 蛋白致细胞周期紊乱的分子机理。方法　构建 Ｈ Ｂｘ 基因真核表达载体ｐ Ｃ Ｅ Ｐ４ Ｘ,电转染入 Ｈｅｐ Ｇ２ 细胞（ Ｘ 细胞） ,以ｐ Ｃ Ｅ Ｐ４空载体为对照（ Ｘ０ 细胞） ,潮霉素选择培养,克隆扩增转染细胞,经无血清培养同步化后,流式细胞仪检测细胞周期变化;细胞组化和 Ｗｅｓｔｅｒｎ ｂｌｏｔ 检测增殖细胞核抗原（ Ｐ Ｃ Ｎ Ａ） 和ｐ２１ Ｃ Ｉ Ｐ１／ Ｗ Ａ Ｆ１ 表达变化。结果　流式细胞仪检测示对照 Ｘ０ 细胞７０ ％ 进入 Ｇ０ Ｇ１ 期,而转 Ｘ 细胞仅５６ ％ 进入 Ｇ０ Ｇ１ 期,与含血清培养的亲本细胞 Ｈｅｐ Ｇ２ 几乎相同。ｐ２１ Ｃ Ｉ Ｐ１／ Ｗ Ａ Ｆ１ Ｄ 表达在 Ｘ０ 细胞阳性率为（８６ ±８） ％ , Ｘ 细胞为（１６ ±６） ％ 。 Ｐ Ｃ Ｎ Ａ 表达在 Ｘ０ 细胞阳性率为（９ ±５） ％ , Ｘ 细胞为（８６ ±３） ％ 。结论　 Ｈ Ｂｘ 有推进细胞周期作用,并使细胞生长对血清依赖减少。 Ｈ Ｂｘ 可抑制细胞周期抑制蛋白ｐ２１ Ｃ Ｉ Ｐ１／ Ｗ Ａ Ｆ１ 表达,同时增强细胞 Ｄ Ｎ Ａ 合成。     

反义寡脱氧核苷酸对人肝癌裸鼠模型生长及转移的影响

目的 观察反义Ｈ－ｒａｓ寡脱氧核苷酸（ＯＤＮ）对高表达蛋白ｐ２１Ｈ- ｒａｓ的人肝癌高转移裸鼠模型ＬＣＩ－Ｄ２０细胞生长、凋亡及转移潜能的影响。方法原代培养ＬＣＩ－Ｄ２０细胞，经１０μｍｏｌ／Ｌ浓度反义ＯＤＮ处理后，以１．５×１０细胞数分别接种于１４只裸鼠皮下缝制皮囊内：６只接种反义Ｈ－ｒａｓＯＤＮ处理细胞，４只接种Ｈ－ｒａｓ非特异性反义ＯＤＮ处理细胞，余４只接种未作处理的对照细胞。结果反义Ｈ－ｒａｓ对ＬＣＩ－Ｄ２０细胞增殖具有显著抑制作用（ｔ＝３１．５２９，Ｐ＜０．０１），反义ＯＤＮ处理细胞，Ｓ期比率（３６．０±１．４）显著低于对照组（５８．５±０．９，ｔ＝１３．５１９，Ｐ＜０．０１），而Ｇ１／Ｇ０期比率（５６．７％±１．１％）高于对照组（３７．４±０．７，ｔ＝１４．８０２，Ｐ＜０．０１）；反义Ｈ－ｒａｓＯＤＮ处理细胞的凋亡发生率（３４．０％±４．５％）显著高于对照组（２．５％±１．２％，ｔ＝１３．４３４，Ｐ＜０．０１）；反义Ｈ－ｒａｓ处理对ＬＣＩ－Ｄ２０细胞在接种动物体内的生长具有显著延迟抑制作用（ｔ＝３．５０９，ｔ＝３．４５２，Ｐ＜０．０１）；接种动物的肺转移率，反义Ｈ－ｒａｓＯＤＮ处理组显著低于对照组。     

血液稀释对急性心肌梗塞兔循环功能及心肌应激性的影响

取家兔１６只，冠状动脉左室支结扎后均分为血液稀释组（ＨＤ）和正常红细胞压积（Ｈｃｔ）组（ＮＧ）。另取兔８只仅行开胸手术作为对照组（ＣＧ）。观察血液稀释对心肌梗塞兔循环。肾上腺素诱发室性心律失常剂量（Ｅ／Ｖ）及梗塞区大小的影响。结果Ｈｃｔ：ＨＤ３１．３±２．７％，ＮＧ３８．１±２．６２％，ＣＧ３９．１±１．６％。冠状动脉结扎后至半小时内三组ＨＲ，ＭＡＰ，ＣＶＰ及心肌耗氧量均明显增加。ＨＤ的增加达１ｈ（Ｐ＜０．０５）。（ＥＩＶ：ＣＯ２３．３±４．５μｇ·ｋｇ－１，ＨＤ１８．０±２．９５μｇ·ｋｇ－１（Ｐ＞０．０５），ＮＧ，６．８６±１．７μｇ·ｋｇ－１，差异显著（Ｐ＜０．０５）。心肌梗塞区占全心重ＨＤ为６．４％，ＮＧ８．１％。（Ｐ＞０．０５）。证实血液稀释有提高心肌应激性，成少室性心律失常，改善心肌微循环和减小梗塞范围的功效。     

卡托普利治疗高血压病伴糖尿病及糖尿病肾病的临床观察

选择２６例原发性高血压（ＥＨ）伴Ⅱ型糖尿病（ＮＩＤＤＭ），其中糖尿病肾病（ＤＮ）１２例，加用卡托普利３７．５～１１２．５ｍｇ／日口服治疗，共４周．结果：收缩压（ＳＢＰ）／舒张庄（ＤＢＰ）由２１．９±２．３／１３．５±０．５ｋｐ＿ａ降为１９．３±１．５／１２．２±０．８Ｋｐ＿ａ（Ｐ＜０．０１），空腹血糖／餐后２小时血糖由１０．７±４．５／１３．７±３．９ｍｍｏｌ／Ｌ减为６．５±１．６／１０．２±２．７ｍｍｏｌ／Ｌ（Ｐ＜０．０１）；２４小时尿蛋白由１．９±０．３ｇ减为０．６±０．３ｇ（Ｐ＜０．０１）．表明该药在降压的同时确有改善糖代谢、降低尿蛋白排泄的作用。     

内源性高甘油三酯血症患者血浆高密度脂蛋白亚类分析

内源性高甘油三酯血症（ＨＴＧ）常伴血浆ＨＤＬ－Ｃ含量下降及ＨＤＬ组成异常。为了研究ＨＴＧ患者血浆ＨＤＬ亚类的改变,作者建立了密度梯度聚丙烯酰胺梯度凝胶电泳法（ＧＧＥ）,对２５例ＨＴＧ患者（血浆ＴＧ＞２．２６ｍｍｏｌ／Ｌ,ＴＣ＜６．７２ｍｍｏｌ／Ｌ）及２５例年龄、性别匹配的血脂正常者（血浆ＴＧ＜１．６９ｍｍｏｌ／Ｌ,ＴＣ＜５．１７ｍｍｏｌ／Ｌ）的ＨＤＬ亚类——ＨＤＬ２ａ、ＨＤＬ２ｂ、ＨＤＬ３ａ、ＨＤＬ３ｂ和ＨＤＬ３ｃ进行了分析,同时对血浆及ＨＤＬ中脂质及载脂蛋白（ａｐｏ）ＡⅠ、ＡⅡ、Ｂ１００、ＣⅡ、ＣⅢ及Ｅ进行了测定。结果发现,ＨＴＧ患者空腹血浆ＴＧ、ａｐｏＢ１００、ａｐｏＣⅡ、ａｐｃＣⅢ及ａｐｏＥ显著增加（Ｐ＜０．００１）,ＨＤＬ－Ｃ及ａｐｏＡⅠ显著降低（Ｐ＜０．００１及Ｐ＜０．０５）;患者血浆ＨＤＬ组成异常,ＨＤＬ中ＴＧ含量显著增加（Ｐ＜０．００１）,ＴＣ、ａｐｏＡⅠ、ａｐｏＣⅡ、ａｐｏＣⅢ及ａｐｏＥ含量下降（Ｐ＜０．０１）;患者血浆ＨＤＬ亚类含量改变,ＨＤＬ２ｂ显著降低（Ｐ＜０．０２）,ＨＤＬ２ａ及ＨＤＬ３ａ增加（Ｐ＜０．０５）,且随血浆ＴＧ含量的升高而升高,ＨＤＬ３ｂ及ＨＤＬ３ｃ则未见改变     

高血压病和冠心病患者血浆脂蛋白（a）水平及其与其它脂类的相关性

观察了２７例高血压病（ＰＨＴ）、１９例冠心病（ＣＨＤ）患者和４０例正常对照（ＮＣ）者血浆脂蛋白（ａ）（Ｌｐ（ａ））的水平，并分析了各组Ｌｐ（ａ）与其它脂类的相关性。结果显示，ＰＨＴ组Ｌｐ（ａ）水平为２４０．５±１２２．４ｍｇ／Ｌ，ＣＨＤ组为２２０．７±１２６．５ｍｇ／Ｌ，两组均显著高于ＮＣ组的１６６．５±７６．１ｍｇ／Ｌ（分别为Ｐ＜０．０１和Ｐ＜０．０５，血浆Ｌｐ（ａ）与甘油三酯ＴＧ）、总胆固醇（ＴＣ）、载脂蛋白Ａｌ（Ａｐｏａｌ）、载脂蛋白Ｂ（ＡｐｏＢ）和ＡｏｏＡｌ／ＡｐｏＢ的比值之间均无显著相关性（Ｐ＜０．０５）。表明：Ｌｐ（ａ）可通过干扰脂质代谢和纤溶过程而发挥其致动脉粥样硬化（ＡＳ）作用，它是ＣＨＤ的独立危险因子。Ｌｐ（ａ）可能在ＰＨＴ的发生与发展过程中也起一定作用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Dr.Zhang Ren's Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.