含萘基团对铜离子具有高选择性的化学荧光传感器

设计合成了一种新的含萘和二吡啶甲基胺基团的荧光化学传感器,并利用氢核磁波谱和质谱对其结构进行了表征.新合成的化合物在乙腈和水的混合溶液中表现出了对二价铜离子具有很高的选择性,与铜离子的键合增强了其荧光强度.荧光和激发光谱滴定表明传感器分子与二价铜离子形成了1∶2的配合物.化合物中的N与铜离子的配位阻止了电子从分子中的N...     

基于吖啶的荧光化学传感器研究进展

吖啶具有刚性平面结构,荧光性能十分优越,因此可以用于荧光化学传感器的合成.本文作者综述了近几年来吖啶类荧光化学传感器的研究进展;介绍了吖啶类荧光化学传感器对阳离子、阴离子和手性化合物的识别性能,并展望了此类传感器的理论和应用前景.     

铜离子作为主客体的双通道化学传感器的研究进展

铜离子在人体各种生理过程中起着重要的作用,生物体中铜离子浓度的失衡会引起一些相应的疾病,因此对于铜离子的研究至关重要.所谓双通道化学传感器,是指可以选择性识别两种离子或者分子的一类化学传感器,相比于单通道化学传感器,该类传感器具有功能多样化的特点.近年来,一些关于铜离子作为主客体的双通道化学传感器被广泛报道.基于此,综述了近年来铜离子作为主客体的双通道化学传感器的研究进展.     

多肽荧光传感器检测铜离子

基于铜离子对罗丹明B标记的多肽的荧光猝灭作用, 构建了一种用于铜离子检测的荧光传感器. 利用共振光散射分析、 紫外-可见吸收光谱、 荧光寿命测试和圆二色光谱研究了铜离子检测的传感机理, 发现铜离子的加入诱导多肽结构发生变化而使罗丹明B荧光团彼此靠近, 从而导致铜离子与多肽之间发生聚集诱导荧光猝灭. 实验结果表明, 该传感器检测铜离子的线性范围为5×10^?4~1×10^?2 μmol/L和0.1~7 μmol/L, 检出限为0.29 nmol/L, 且拥有良好的选择性, 能用于湖水样品中铜离子的检测.     

薄膜荧光传感器研究进展

按薄膜荧光传感器的制备方法, 从物理薄膜、化学薄膜和自组装单层膜等三个方面综述了近年来薄膜荧光传感器的研究进展. 在此基础上, 展望了薄膜荧光传感器的研究前景.     

新型有机荧光探针分子的设计合成及在生物医学中的应用

近年来,荧光化学传感器以其高选择性、高灵敏度、实时原位监测、简便快捷等优点,受到人们的普遍欢迎.开发一些具有高灵敏度、高选择性、实时原位检测性能的荧光化学传感器,特别是开发一些具有实际应用价值的荧光化学传感器,一直都是人们追求的目标.论文根据分子识别和光化学传感的基本原理,结合生物医学检测的需要,设计了几种能够在水相中识别生物医学上重要生物活性分子的荧光探针分子.主要工作和结果概述如下.     

基于咔唑衍生物的荧光化学传感器的合成及其对金属离子的选择性识别性能

以咔唑为原料合成了2个荧光化学传感器,所得化合物的组成和结构经元素分析以及质谱、红外光谱、核磁共振氢谱验证.通过在25℃下进行荧光光谱滴定,研究了传感器在体积比为1∶1的二甲基亚砜/水缓冲溶液[三羟甲基氨基甲烷盐酸盐(Tris-HCl),pH=7.4]中对Cu2+和Fe3+的选择性识别作用.结果表明,所合成的传感器与Cu2+和Fe3+形成1∶1的配合物并导致荧光猝灭,并对Cu2+离子和Fe3+离子具有较高的选择性识别和荧光传感性能.     

荧光化学传感器的研究进展

从荧光指示剂的设计原理、固定方法及传感器材料三方面,对荧光化学传感器近年来的进展作了评述,特别是对一些新型荧光化学传感器的应用及纳米传感新材料的发展作了重点介绍。此外,对荧光化学传感器的发展前景作了展望。     

一种检测2,4,6-三硝基苯酚的荧光化学传感器及其制备方法

本发明提供了一种检测2,4,6-三硝基苯酚的荧光化学传感器及其制备方法,属于功能高分子材料制备和化学分析技术领域。所述荧光化学传感器的制备方法包括如下步骤:(1)在缚酸剂存在的条件下,利用六氯环三膦腈与姜黄素在有机溶剂中发生缩聚反应,得溶液;(2)分离溶液中的固体产物,洗涤并干燥,得荧光化学传感器。本发明基于环交联型聚膦腈的荧光化学传感器的制备,过程简单温和,具有优异的热稳定性、化学稳定性和荧光特性,可实现液相中2,4,6-三硝基苯酚的特异性识别和检测,且灵敏度高,适用于痕量爆炸物检测及环境监测领域,有利于实现工业化生产。     

基于罗丹明的Hg~(2+)荧光传感器及其细胞成像研究

报道一个新的罗丹明衍生物FD10构建高选择性识别Hg2+的荧光化学传感器.Hg2+的存在诱导FD10的荧光增强了近100倍,同时伴随着明显的颜色变化.重要的是,激光共聚焦荧光成像实验表明FD10可用于细胞内Hg2+的示踪.     

Rhodamine-based chemosensing monolayers on glass as a facile fluorescent “turn-on” sensing film for selective detection of Pb

Rhodamine-based chemosensors 1 and 2 were synthesized and self-assembled onto glass surfaces for the selective fluorescent sensing of Pb²⁺. The immobilized chemosensors showed fluorescent responses that were turned-on with Pb²⁺ in CH₃CN, selectively over various metal ions. The Pb²⁺-selective fluorescent switch of the immobilized chemosensors was also reversible, allowing for repeated use for Pb²⁺ detection.     

Synthesis of porphyrin-diazacrown ether and porphyrin-cryptand conjugates for fluorescence detection of copper(II) ions

Palladium-catalyzed amination was used for the synthesis of the macrocycles containing trioxadiamine linker and the fragments of either 3,3′-disubstituted biphenyl or 2,7-disubstituted naphthalene. Catalytic macrocyclization gives diazacrown ether-based cryptand with trioxadiamine linker. The synthesized compounds were involved in Pd-catalyzed arylation of zinc meso-(bromophenyl)porphyrin to obtain polymacrocyclic conjugates bearing one or two porphyrin units. The synthesized conjugates were studied as fluorescence sensing material and molecular probes for 18 metal ions. It was found that two of them are very promising fluorescent chemosensors for copper(II) cations.     

Highly selective chromogenic and redox or fluorescent sensors of Hg2+ in aqueous environment based on 1,4-disubstituted azines

Two new chemosensors that exhibit high affinity and high selectivity for Hg2+ in aqueous environment which operate through two different channels, optic/redox and optic/fluorescent, are reported. The optical change in sensing can be used even for a "naked-eye" detection of Hg2+ ions, whereas the fluorescent response can be modulated by varying the solvent polarity.     

New chemosensory materials based on disubstituted polyacetylene with strong green fluorescence

A new imidazole‐containing disubstituted polyacetylene ( P1 ) with strong green fluorescence was successfully prepared through polymer reaction, which was nearly impossible to be obtained from the direct polymerization of its corresponding monomer. The polymer was soluble in common organic solvents, and its strong green fluorescence could be quenched completely by the Cu²⁺ and Co²⁺ ions, at the concentrations as low as 1.33 and 1.67 × 10⁻⁵ mol/L (0.85 and 0.92 ppm), respectively. Because of the high stability of the complex formed by cyanide and copper ions, the quenched green fluorescence of P1 by copper ions could be turned on upon the addition of trace cyanide (as low as 2.70 × 10⁻⁵ mol/L, 0.70 ppm), making P1 a new sensitive cyanide chemosensor. The results thus provided a new opportunity to develop anion chemosensors based on good cation chemosensors. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 8070–8080, 2008     

Thiacalix[4]arene based reconfigurable molecular switches: set-reset memorized sequential device

The fluorescent chemosensors 3, 5 and 7 based on thiacalix[4]arene bearing naphthyl groups have been designed and synthesized. The optical chemosensor 3 based on a thiacalix[4]arene of cone conformation behaves as "turn-on" optical chemosensor for Fe(3+) and F(-) ions. However, chemosensors 5 and 7 based on a thiacalix[4]arene of 1,3-alternate conformation demonstrate "turn-on" optical behaviour for Hg(2+), F(-) ions (with receptor 5 as turn-on for K(+) ions also) and "turn-off" behaviour for Fe(3+) ions. The simultaneous presence of Fe(3+) and Hg(2+) or K(+) or F(-) ions results in formulation of reversible "on-off" switches. Various molecular logic gates developed in response to molecular switching between these chemical inputs have been integrated into sequential logic circuits with memory function in a feedback loop which mimics "set-reset" molecular level information processing device.     

Rhodamine-based chemosensing monolayers on glass as a facile fluorescent "turn-on" sensing film for selective detection of Pb2+

Rhodamine-based chemosensors 1 and 2 were synthesized and self-assembled onto glass surfaces for the selective fluorescent sensing of Pb(2+). The immobilized chemosensors showed fluorescent responses that were turned-on with Pb(2+) in CH(3)CN, selectively over various metal ions. The Pb(2+)-selective fluorescent switch of the immobilized chemosensors was also reversible, allowing for repeated use for Pb(2+) detection.     

含芘荧光化学敏感器化合物同小牛胸腺DNA分子间的相互作用

研究了含芘荧光化学敏感器分子被ctDNA猝灭的荧光光谱.ctDNA分子对该化学敏感器中芘的激发单体,激基缔合物都有猝灭作用.对激发单体的猝灭速度顺序为;化合物(2)>化合物(1)>芘丁酸>化合物(3);对激基缔合物的猝灭速度顺序为;化合物(2)化合物(3).由得到的荧光猝灭数据,可按公式(2)求得荧光化学敏感器分子与ctDNA分子相互作用的稳定常数.发现化合物(2)与ctDNA分子间有着最强的相互作用能力.按ctDNA和含芘荧光化学敏感器的分子结构、构型以及分子内原子-原子的间距等提出了ctDNA分子与该荧光化学敏感器的作用模型,并对上述结果进行了初步解释.     

Synthesis and evaluation of a novel pyrenyl-appended triazole-based thiacalix[4]arene as a fluorescent sensor for Ag ion

New fluorescent chemosensors 1,3-alternate-1 and 2 with pyrenyl-appended triazole-based on thiacalix[4]arene were synthesized. The fluorescence spectra changes suggested that chemosensors 1 and 2 are highly selective for Ag⁺ over other metal ions by enhancing the monomer emission of pyrene in neutral solution. However, other heavy metal ions, such as Cu²⁺, and Hg²⁺ quench both the monomer and excimer emission of pyrene acutely. The ¹H NMR results indicated that Ag⁺ can be selectively recognized by the triazole moieties on the receptors 1 and 2 together with the ionophoricity cavity formed by the two inverted benzene rings and sulfur atoms of the thiacalix[4]arene.     

Fluorescence "turn on" chemosensors for Ag+ and Hg2+ based on tetraphenylethylene motif featuring adenine and thymine moieties

Two new tetraphenylethylene (TPE) compounds 1 and 2 bearing adenine and thymine moieties, respectively, were found to be fluorescence "turn on" chemosensors for Ag(+) and Hg(2+) by making use of the AIE feature of TPE motif and the specific binding of adenine/thymine with Ag(+)/Hg(2+).     

Synthesis and evaluation of a pseudocyclic tristhiourea-based anion host

A novel methodology for the evaluation of receptor arrangement in structurally flexible anion chemosensors was developed and applied to map the binding site of a new pseudocyclic tristhiourea chemosensor (6). The syntheses of 6 and related macrocyclic chemosensor 10 (a model of the folded monomeric structure of 6) are reported. Both chemosensors were evaluated by titration with a variety of structurally different anions in CH3Cl and DMSO, showing a common preference for F-, CH3CO2-, and H2PO4-. However, within this group of anions, the binding patterns of the chemosensors differed, indicating dissimilarity in the arrangement of the binding sites of 6 and 10.