Synthesis and evaluation of a pseudocyclic tristhiourea-based anion host |
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Authors: | Dahan Adi Ashkenazi Tali Kuznetsov Vladimir Makievski Svetlana Drug Eyal Fadeev Ludmila Bramson Maayan Schokoroy Sari Rozenshine-Kemelmakher Emily Gozin Michael |
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Affiliation: | School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel. |
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Abstract: | A novel methodology for the evaluation of receptor arrangement in structurally flexible anion chemosensors was developed and applied to map the binding site of a new pseudocyclic tristhiourea chemosensor (6). The syntheses of 6 and related macrocyclic chemosensor 10 (a model of the folded monomeric structure of 6) are reported. Both chemosensors were evaluated by titration with a variety of structurally different anions in CH3Cl and DMSO, showing a common preference for F-, CH3CO2-, and H2PO4-. However, within this group of anions, the binding patterns of the chemosensors differed, indicating dissimilarity in the arrangement of the binding sites of 6 and 10. |
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