阿卡波糖对2型糖尿病病人胰岛素抵抗的影响

目的 :探讨阿卡波糖对 2型糖尿病病人胰岛素抵抗的影响。方法 :16 0例 2型糖尿病病人随机分为 2组 ,治疗组 80例口服阿卡波糖治疗 ,前 2wk ,5 0mg ,po ,tid ,2wk后 ,10 0mg ,po ,tid ;安慰剂组 80例口服安慰剂 ,方法同治疗组 ,疗程为 2 4wk。同时观察空腹及餐后 2h血糖、血清胰岛素水平、体重指数、糖化血红蛋白、空腹时的红细胞胰岛素受体和红细胞膜流动性治疗前后变化。结果 :(1)wk 4时 ,阿卡波糖明显降低病人的空腹血糖、餐后 2h血糖、糖化血红蛋白 ,下降值分别为 :(2 .9±s 0 .8)mmol·L- 1,(4.0± 1.8)mmol·L- 1,(1.2± 2 .1) % ,P<0 .0 1;(2 ) 2 4wk后 ,阿卡波糖降低病人的体重、空腹血清胰岛素、餐后 2h血清胰岛素 ,下降值分别为 :(6± 4 )kg·m- 2 ,(10± 6 )MIU·L- 1,(14± 10 )MIU·L- 1,增加红细胞胰岛素受体 ,升高值为 :(80± 71)sites·RBC- 1,降低膜流动性 ,下降值为 :(1.5± 1.3) ,P <0 .0 1。结论 :阿卡波糖能改善 2型糖尿病病人的胰岛素抵抗

Influence of acarbose on insulin resistant of patients with type 2 diabetes mellitus

AIM: To investigate the effect of acarbose on the insulin resistant of the patient with type 2 diabetes mellitus(DM). METHODS: One hundred and sixty patients with type 2 DM were divided into two groups. Treatment group, 80 patients with type 2 DM were treated with acarbose. Placebo group, 80 patients with type 2 DM were treated with placebo. They were treated for 24 wk. FPG,PPG,BMI, GHbAIc, FINS, EIR, and EMF were tested. RESULTS: After 4 wk treatment,acarbose had significant effect on lowering the fasting and postprandial 2h blood glucose and glycosylated haemoglobins (GHbAIc)( P < 0.01 ).Their margins were (-2.9±0.8) mmol·L -1 ,(-4.0±1.8)mmol·L -1 , (-1.2±2.1) %. After 24 wk treatment, acarbose had significant effect on lowering body weight and the fasting and postprandial 2 h insulin( P < 0.05). Their margins were (6±4) kg·m -2 ,( 10±6) MIU·L -1 , (14±10) MIU·L -1 .The binding capacity of erythrocyte insulin receptor increased significancely( P <0.01 ) and erythrocyte membrane fluidity decreased significancely( P < 0.01). Their margins were (80±71) sites·RBC -1 and (-1.5±1.3)( P <0.01). CONCLUSION: Acarbose can improve insulin sensitivity in patients with type 2 DM.