冠心病患者血清IL-1β和IL--6含量与冠脉病变的关系

目的：探讨血清自细胞介素（IL）-1β、IL--6水平对冠心病发病和严重度的预测作用。方法：70例冠心病患者，按临床诊断分为2组：急性冠脉综合症组32例和稳定型心绞痛组38例，另有对照组患者30例。ELISA检测各组患者血清中IL--1β、IL--6水平，并比较各组间的差异。冠脉造影术对冠脉病变进行Gensini评分，并了解其与血清中IL-1β、IL--6水平的相关性。结果：冠心病患者血清中的IL-1β、IL-6水平显著高于正常对照组（P〈O．05）；在冠心病组内，急性冠脉综合症组的血清IL-6水平显著高于稳定型心绞痛患者（P〈0.05）。冠脉病变Gensini评分与血清中IL-6水平呈正相关（r=0．358，P〈0．05）。结论：IL-1β、IL-6可能参与了冠状动脉粥样硬化的发生和发展过程，其血清水平可能是冠状动脉粥样硬化的-个炎性标志。

Relationship between levels of serum IL-1β,IL-6 and coronary heart disease

Objective： To study the relationship between levels of interleukin （IL） --1β, IL--6 and coronary heart disease. Methods： The three groups included 32 eases of acute coronary syndrome （ACS）, 38 eases of stabilize angina pectoris （SAP） and 30 cases with normal coronary artery; serum level of IL--1β and IL--6 were measured by enzyme-linked immunosorbent assay, the severity and extent of coronary lesions was analyzed by coronary angiography and typified by means of Gensini coronary score system. Results： The serum level of IL--1β and IL--6 significantly elevated in coronary heart disease groups as compared to control groups （P〈0.05） ; in addition, serum level of IL-- 6 significantly elevated in ACS groups （P〈.0.05） as compared to SAP groups. Positive correlation was seen between the severity of coronary lesions and the serum level of IL--6 （fl=0. 358, P%0.05）. Conclusion： IL--1β and IL--6 may be a marker of coronary heat disease; similarly, measurement of it may be helpful for diagnosing coronary plaque destabilization and the severity of coronary heart disease.