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排序方式: 共有1599条查询结果,搜索用时 31 毫秒
1.
Patel Mallika P. Kirkpatrick John P. Johnson Margaret O. Healy Patrick Herndon James E. Lipp Eric S. Miller Elizabeth S. Desjardins Annick Randazzo Dina Friedman Henry S. Ashley David M. Peters Katherine B. 《Journal of neuro-oncology》2020,147(2):477-483
Journal of Neuro-Oncology - Primary central nervous system lymphoma (PCNSL) is a subtype of non-Hodgkin’s lymphoma that involves the brain, spinal cord, or leptomeninges, without evidence of... 相似文献
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Michael Bauer Uwe Kölsch Renate Krüger Nadine Unterwalder Karin Hameister Fabian Marc Kaiser Aglaia Vignoli Rainer Rossi Maria Pilar Botella Magdalena Budisteanu Monica Rosello Carmen Orellana Maria Isabel Tejada Sorina Mihaela Papuc Oliver Patat Sophie Julia Renaud Touraine Thusari Gomes Kirsten Wenner Xiu Xu Alexandra Afenjar Annick Toutain Nicole Philip Aleksandra Jezela-Stanek Ludwig Gortner Francisco Martinez Bernard Echenne Volker Wahn Christian Meisel Dagmar Wieczorek Salima El-Chehadeh Hilde Van Esch Horst von Bernuth 《Journal of clinical immunology》2015,35(2):168-181
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Lior Greenbaum Yinon Gilboa Annick Raas-Rothschild Ortal Barel Nitzan Kol Haike Reznik-Wolf Ben Pode-Shakked Yael Finezilber Baruch Messing Michal Berkenstadt 《European journal of medical genetics》2019,62(3):167-171
Diaphanospondylodysostosis (DSD) is a rare autosomal recessive skeletal disorder, characterized mainly by ossification defects in vertebrae, thorax malformations, renal cystic dysplasia and usually death in the perinatal period. DSD is caused by mutations in the bone morphogenetic protein-binding endothelial regulator (BMPER) gene. We describe the prenatal findings of a non-consanguineous Jewish couple (shared Balkan origin), with three affected fetuses that presented with malformations in the spine and chest, reduced ossification of the skull and spine, horseshoe kidney and increased nuchal translucency. The unique combination of these ultrasound (US) features raised the possibility of DSD, which was confirmed by whole exome sequencing (WES) performed on a single fetal DNA and familial segregation. In the three fetuses, a novel homozygous mutation in BMPER (c.410T?>?A; p.Val137Asp) was found. This mutation, which segregated in the family, was not found in 65 controls of Jewish Balkan origin, and in several large databases. Taken together, the combination of a detailed prenatal US examination and WES may be highly effective in confirming the diagnosis of a rare genetic disease, in this case DSD. 相似文献
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Rémy De Mil Elodie Guillaume Lydia Guittet Olivier Dejardin Véronique Bouvier Carole Pornet Véronique Christophe Annick Notari Hélène Delattre-Massy Chantal De Seze Jérôme Peng Guy Launoy Célia Berchi 《Value in health》2018,21(6):685-691
Background
Patient navigation programs to increase colorectal cancer (CRC) screening adherence have become widespread in recent years, especially among deprived populations.Objectives
To evaluate the cost-effectiveness of the first patient navigation program in France.Methods
A total of 16,250 participants were randomized to either the usual screening group (n = 8145) or the navigation group (n = 8105). Navigation consisted of personalized support provided by social workers. A cost-effectiveness analysis of navigation versus usual screening was conducted from the payer perspective in the Picardy region of northern France. We considered nonmedical direct costs in the analysis.Results
Navigation was associated with a significant increase of 3.3% (24.4% vs. 21.1%; P = 0.003) in participation. The increase in participation was higher among affluent participants (+4.1%; P = 0.01) than among deprived ones (+2.6%; P = 0.07). The cost per additional individual screened by navigation compared with usual screening (incremental cost-effectiveness ratio) was €1212 globally and €1527 among deprived participants. Results were sensitive to navigator wages and to the intervention effectiveness whose variations had the greatest impact on the incremental cost-effectiveness ratio.Conclusions
Patient navigation aiming at increasing CRC screening participation is more efficient among affluent individuals. Nevertheless, when the intervention is implemented for the entire population, social inequalities in CRC screening adherence increase. To reduce social inequalities, patient navigation should therefore be restricted to deprived populations, despite not being the most cost-effective strategy, and accepted to bear a higher extra cost per additional individual screened. 相似文献6.
Linssen CF Jacobs JA Stelma FF van Mook WN Terporten P Vink C Drent M Bruggeman CA Smismans A 《Intensive care medicine》2008,34(12):2202-2209
Objective To evaluate the relationship between the HSV-1 and -2 loads in BAL fluid (BALF) and clinical outcome.
Design Retrospective study.
Setting The general intensive care unit of the University Hospital Maastricht.
Patients Five hundred and twenty-one BALF samples from 462 patients were included. Patients were divided into three groups; (1) patients
admitted to the hospital <48 h before lavage (Community), (2) patients admitted to the ICU >48 h before lavage (ICU) and (3)
the remaining patients (non-ICU group).
Interventions No additional interventions were conducted.
Measurements and results HSV-1 and HSV-2 loads were determined by real-time polymerase chain reaction (PCR). HSV-1 DNA was detected in 4.3% (4/92)
of samples in the community group, 15% (18/121) in the non-ICU group and in 32% (99/308) of the ICU group. In the age group
<50 years HSV-1 DNA was less frequently isolated compared to the age group ≥50 years (16/129 (12%) versus 187/376 (25%), respectively,
OR = 2.6; P < 0.001). HSV-1 loads of >105 genome equivalents (ge)/ml were associated with an increased 14-day in-hospital mortality compared to patients with a HSV-1
load ≤105 ge/ml in BALF (41 vs. 20%, respectively, P = 0.001). HSV-1 pneumonia was histologically proven in two patients with a HSV-1 load exceeding 105 ge/ml.
Conclusions HSV-1 occurred more in critically ill patients and high loads in BALF were associated with an increased mortality. The higher
mortality observed in patients with HSV-1 load >105 ge/ml enforces its clinical relevance and necessitates to start randomized medical intervention studies.
The abstract of this article was published in ESCV/SGM Conference, Birmingham, as an oral presentation. 相似文献
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Charles Tacquard MD Olivier Collange MD PhD Anne Olland MD Tristan Dégot MD Annick Steib MD 《Journal canadien d'anesthésie》2014,61(4):357-361
Purpose
To describe tracheal rupture after orotracheal intubation assisted by a tracheal tube introducer.Clinical features
A 73-yr-old morbidly obese female patient with a history of hypertension underwent a total knee replacement. There were no anticipated signs of difficult intubation. Orotracheal intubation was attempted twice by direct laryngoscopy, and a Boussignac bougie was used as a tube exchanger for the second attempt. Seven hours after tracheal extubation, the patient became dyspneic and showed a large subcutaneous emphysema. A chest x-ray and computerized tomography scan revealed rupture of the posterior tracheal wall. The distal part of the injury was 26.5 cm from the patient’s teeth and 0.5 cm from the carina (i.e., beyond the normal location of the tracheal tube tip) and extended to the origin of the right main bronchus, where the tip of the Boussignac bougie was probably pushed. Formation of an endotracheal sac occurred during the first two weeks after intubation, accompanied by dyspnea and alveolar hypoventilation, but symptoms resolved favourably with conservative management.Conclusion
The tracheal rupture was attributed to airway manipulations, and the distal location of the lesion suggests that the cause was the Boussignac bougie rather than the tracheal tube. Long-term healing of the injury was satisfactory, although the patient continued to complain of dyspnea one year after the rupture. 相似文献9.
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