Inhibition of α-Amylase and α-Glucosidase by New β-Aminopropionamidoxime Derivatives

Pharmaceutical Chemistry Journal - New antidiabetic agents are being sought because of the global problem with diabetes. Amidoxime derivatives are known to have antidiabetic activity....     

Prevalence of bronchial asthma in Uzbekistan

The prevalence of bronchial asthma has tended to increase in Uzbekistan. It is highest in the Republic of Karakalpakstan and least in the Samarkand Region. Its prevalence differs in some areas of Uzbekistan--highest in children in Karakalpakstan and in elderly persons in Tashkent. The prevalence of bronchial asthma is associated with smoking.     

Analysis of bronchial hypersensitivity in patients with bronchial asthma

AIM: To analyse correlation between bronchial hypersensitivity in bronchial asthma (BA) and environmental factors; to propose methods of relevant correction. MATERIAL AND METHODS: The trial included 97 BA patients (42 males, 55 females) aged 17-79 years. Bronchial sensitivity was studied by means of dose-dependent bronchial resistance curve (Rrs) plotted by the unit Masterlab (Germany) in the course of long-term inhalation of a gradually rising dose of methacholine. A regression analysis was made of the dependence of fluticasone bipropionate effectiveness on clinical symptoms of the disease. RESULTS: Bronchial hypersensitivity depends on initial clinical symptoms of BA, in a less degree on bronchial permeability, severity of inflammation of bronchial mucosa. CONCLUSION: Local corticosteroid fluticasone propionate is a drug of choice in the treatment of mild and moderate BA.     

Default from tuberculosis treatment in Tashkent,Uzbekistan; Who are these defaulters and why do they default?

Background  

In Tashkent (Uzbekistan), TB treatment is provided in accordance with the DOTS strategy. Of 1087 pulmonary TB patients started on treatment in 2005, 228 (21%) defaulted. This study investigates who the defaulters in Tashkent are, when they default and why they default.     

Health-care seeking behaviour for TB symptoms in two provinces of Uzbekistan

In Uzbekistan, mass X-ray screening for TB is still used. The groups targeted are broad and include at least 50% of the population. Of all pulmonary TB cases, 73% are reported to be detected by this method. However, in this study of 85 randomly selected pulmonary TB patients, only 16% confirmed were been detected through this method. Having known risk factors for TB did not increase the likelihood of its being detected, which highlights the need to revise the current screening policy.