Closed loop stimulation helps with weaning from chronotropic incompetence-related ventilator dependence

Journal of Interventional Cardiac Electrophysiology -     

Determining the significance of coagulase-negative staphylococci identified in cultures of paired blood specimens from neonates by species identification and strain clonality.

Of 13 paired coagulase-negative staphylococci (CoNS) isolates recovered from cultures of paired blood specimens obtained simultaneously from peripheral sites from neonates with clinical sepsis, 12 were identical species with identical genotypes. Isolation of CoNS in cultures of 2 blood samples obtained simultaneously from separate sites in neonates usually represents true infection.     

Selection of effective features for ECG beat recognition based on nonlinear correlations

Objective

The objective of this study is to develop feature selectors based on nonlinear correlations in order to select the most effective and least redundant features from an ECG beat classification system based on higher order statistics of subband components and a feed-forward back-propagation neural network, denoted as HOS-DWT-FFBNN.

Methods and materials

Three correlation-based filters (NCBFs) are proposed. Two of them, NCBF1 and NCBF2, apply feature-feature correlation to remove redundant features prior to the feature selection process based on feature-class correlation. The other, SUFCO, skips the redundancy reduction process and selects features based only on feature-class correlation. The performance of these filters is compared to another commonly used nonlinear feature selection method, Relief-F. The discriminality and redundancy of the retained features are evaluated quantitatively. The performance of the most effective NCBF is compared with that of the linear correlation-based filter (LCBF) and other representative heartbeat classifiers in the literature.

Results

The results demonstrate that the two NCBFs based on both feature-feature and feature-class correlation methods, i.e. NCBF1 and NCBF2, outperform the other two methods, i.e. SUFCO and Relief-F. An accuracy of as high as 96.34% can be attained with as few as eight features. When tested with statistical methods, the retained features selected by the NCBF1/NCBF2 approach are demonstrated to be more discriminative and less redundant when compared with those features selected by other methods. When compared with LCBF and other heartbeat classifiers in the literature, the proposed NCBF1/NCBF2 approach in conjunction with the HOS-DWT-FFBNN structure outperform them with improved performance that allows discrimination of more beat types and fewer feature dimensions.

Conclusion

This study demonstrates the effectiveness and superiority of the proposed approach for ECG beat recognition.     

Impact of pentraxin 3 genetic variants on uterine cervical cancer clinicopathologic characteristics

The aims of this study were to investigate the relationships among pentraxin 3 (PTX3) genetic variants and development and clinicopathological characteristics of uterine cervical cancer, and patient survival in Taiwanese women. The study enrolled 125 patients with invasive cancer and 98 patients with precancerous lesions of uterine cervix, and 325 control women. PTX3 genetic variants rs2120243, rs3816527, rs2305619 and rs1840680 were selected and their genotypic distributions were determined by real-time polymerase chain reaction. Our results indicated that patients with genotype CC in PTX3 rs2120243 and genotype GG in rs1840680 had more chance to have adenocarcinoma but not squamous cell carcinoma, as compared to those with CA/AA and those with GA/AA, respectively. No other clinicopatholgical characteristics were associated with PTX3 genetic variants. In addition, PTX3 genetic variants were not associated with 5 years survival of cervical cancer patients. In conclusions, PTX3 genetic variants are not associated with carcinogenesis and clinicopathological variables of uterine cervix and patient survival in Taiwanese women. The only independent predictor for the 5 years survival is pelvic lymph node metastasis.     

Booster vaccination at 6-8 years of age with a reduced antigen content dTpa-IPV vaccine is immunogenic and safe after priming with whole-cell pertussis vaccine

Pertussis vaccines containing reduced amounts of antigen have been considered primarily for use in adolescents and adults to date. We evaluated a reduced antigen content combined diphtheria tetanus acellular pertussis and inactivated polio vaccine (dTpa-IPV) in 6-8 years old children in Taiwan, who had received 4 doses of DTPw (combined diphtheria, tetanus, whole cell pertussis vaccine) and OPV (oral polio vaccine). One month after the booster dose, seroprotection rates and vaccine response rates to all antigens were at least 98.8%, and significant increases in antibody concentrations were observed. Booster vaccination was associated with minor local reactions and systemic symptoms. Symptoms of severe intensity did not occur, with the exception of local pain. The dTpa-IPV vaccine was immunogenic and well tolerated in 6-8 years old children and offers an alternative to the current use of tetanus and diphtheria vaccine and OPV in Taiwan, addressing the established need for repeated booster vaccinations against pertussis at the same time.     

Initiation of breastfeeding lessons from Taiwan

A study undertaken in Taiwan in 2001 is reported here with the aim of improving understanding about the socio-cultural factors that may affect a woman's decisions about infant feeding. AIM OF THE STUDY: to determine the current status of infant feeding and the influences of basic sociodemographic characteristics and social support, as well as maternal knowledge and attitudes about breastfeeding. METHODS: A questionnaire including sociological, psychological and medical variables was completed by 195 mothers who were also interviewed individually in the maternity hospital. The mothers were divided into three groups: exclusive breastfeeding group, exclusive bottle feeding group, and mixed-feeding group. RESULTS: The independent factors that increased the ikelihood of formula feeding during the first one to two months of life included (1) mothers were employed, (2) delivery by Cesarean section, (3) grandmothers or other people were the main child caretakers, (4) mothers did not attend the educational courses, and (5) lack of encouragement by the husband. CONCLUSION: Health professionals and policy makers should be aware of the factors that affect a woman's decisions about infant feeding including cultural background and media coverage.