Calculation of the Biological Efficiency of the Proton Component from 14.8 MeV Neutron Irradiation in Computational Biology with Help of Video Cards

Bulletin of Experimental Biology and Medicine - Fast neutron therapy, which previously has demonstrated effective results, but along with a large number of complications, can again be considered a...     

Post-Irradiation Recovery of B14-150 Fibrosarcoma Cells after Combined Irradiation with Low and High Linear Energy Transfer

Bulletin of Experimental Biology and Medicine - The use of radiation with low and high linear energy transfer (LET) in the same treatment regimen is promising in terms of increasing the efficiency...     

Experimental Approaches to Increasing the Content of Sodium Mercaptododecaborate in Tumor Tissues

Pharmaceutical Chemistry Journal -     

Synthesis, toxicity, and mouse biodistribution of 9-thiocyano-7,8-dicarba-nido-undecaborate during neutron-capture therapy

Potassium 7,8-dicarba-nido-undecaborate was thiocyanated by nondiaphragm electrolysis. The salt Me₄N⁺[9-SCN-7,8-C₂B₉H₁₁]⁻ was isolated and converted into the trimethylammonium salt using ion-exchange. Methods for the synthesis of water-soluble sodium 7,8-dicarba-nido-undecaborate and its biphasic iodination (for ¹³¹I introduction) were developed. Thus, the synthesis and analysis of the radioactive iodine-labeled sodium salt of 11-(¹³¹I)-9-thiocyanato-7,8-dicarba-nido-undecaborate were proposed and carried out. The toxicity of the synthesized compound was evaluated. It was established that 100 and 75 mg/kg doses are 100% lethal for test animals while no significant disorders were observed at doses of 35 and 20 mg/kg. The biodistribution of the compound in organs and tissues was studied in mice with melanoma B-16. The maximum accumulation of labeled compound in tumor, skin, muscle, liver, kidneys, and spleen was observed 3 – 6 h after administration. A comparison of drug accumulation in tumor and normal tissues showed that the preparation does not possess pronounced tumor-targeting properties.     

Compounds for neutron capture therapy and their distribution in tumors and surrounding tissues of animals (A review)

Boron-containing compounds for neutron capture therapy (NCT) can be divided into three groups: compounds without specific accumulation in tumor, tumor-selective compounds, and compounds capable of incorporating into the structure of tumor cells. For the NCT of cancer patients, sodium mercaptododecaborate (BSH) and p-boronophenylalanine (BPA) were selected from several hundred of boron-containing compounds. In this paper, data on the distribution of BSH and BPAin the organism of animals with model tumors modeling those encountered in oncological patients are reviewed. Methods for increasing the boron uptake in tumor, based on the combined use of boron compounds and modification factors such as hyperthermia, effect of electric pulses on the tumor zone, administration of compounds possessing vasodilating properties and influencing the blood-brain barrier permeability, are considered. __________ Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 11, pp. 3–7, November, 2006.     

Phenotype correction of Ir-genic control of immune response to (T,G)-A-L conjugated to synthetic polyelectrolytes

Experiments in CBA (H-2k) and C57BL/6 (H-2b) strains of mice have shown (T,G)-A-L covalently bound to synthetic polyelectrolytes possessing immunoadjuvant effect to induce a pronounced antibody and cell-mediated immune response irrespective of murine genotype. When conjugated to the polyelectrolytes (T,G)-A-L was also found to acquire the properties of a highly immunogenic thymus-independent antigen. Thus, (T,G)-A-L-synthetic polyelectrolytes conjugates manifested the effects of highly immunogenic thymus-independent antigens inducing a potent Ir-1-independent immune response. It provided for the transformation of genetically low responder individuals into high responder ones.     

Modification of <Superscript>131</Superscript>I-labeled sodium mercaptododecaborate pharmacokinetics using infrared radiation and vasoactive compounds

The influence of vasodilative (dibazole) and vasoconstrictive (mesatone) drugs on the distribution of sodium mercaptododecaborate labeled with radioactive iodine (¹³¹I-BSH) in melanoma B-16 and surrounding tissues of mice has been studied. It is shown that the administration of dibazole results in a more pronounced increase in the ratio of ¹³¹I-BSH concentrations in the tumor and surrounding tissues in comparison to mesatone. Combined use of infrared radiation and dibazole for the modification of ¹³¹I-BSH distribution in tissues showed a tendency to increase in the ratio of BSH concentrations in the tumor and tissues in comparison to the case of infrared irradiation or dibazole used alone. The results show good prospects for the combined use of IR radiation and drugs for increasing the oncotropic properties of agents for boron neutron capture therapy. __________ Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 3, pp. 3–5, March, 2007.