Alcohol intake and cognitive abilities in old age: The Lothian Birth Cohort 1936 study.

Objective: Moderate alcohol consumption has been associated with better cognitive performance in late adulthood, possibly by improving vascular health. Few studies have examined the potentially confounding roles of prior cognitive ability and social class in this relationship. Method: Participants were 922 healthy adults about 70 years old in the Lothian Birth Cohort 1936 study, for whom there are IQ data from age 11. Alcohol consumption was obtained by self-report questionnaire. Cognitive outcome measures included general cognitive ability, speed of information processing, memory, and verbal ability. Results: Moderate to substantial drinking (>2 units/day) was associated with better performance on cognitive tests than low-level drinking (≤2 units/day) or nondrinking in men and women. After adjusting for childhood IQ and adult social class, most of these associations were removed or substantially attenuated. After full adjustment, a small, positive association remained between overall alcohol intake and memory (women and men) and verbal ability (women only). Women's overall alcohol intake was derived almost exclusively from wine. In men, effects differed according to beverage type: wine and sherry–port consumption was associated with better verbal ability, but beer was associated with a poorer verbal ability and spirits intake was associated with better memory. Conclusions: Prior intelligence and socioeconomic status influence both amount and type of alcohol intake and may partly explain the link between alcohol intake and improved cognitive performance at age 70. Alcohol consumption was found to make a small, independent contribution to memory performance and verbal ability, but these findings' clinical significance is uncertain. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Modeling the effects of hypoglycemia on a two-choice task in adult humans.

Objective: Previous research has demonstrated that hypoglycemia causes reaction times to be slower and more variable. Reaction time tests, however, use multiple cognitive and noncognitive processes. This study is the first to use a validated sequential sampling model (diffusion model) applied to results obtained from a simple 2-choice task in adult humans to assess the effects of hypoglycemia on the basic parameters of decision making. Method: Fourteen adult volunteers were tested on a numerosity discrimination task with and without reduced blood glucose concentrations. The results were analyzed with a model that dissects the components of processing that underlie decisions: the quality of the information on which a decision is based (drift rate), the critical amount of evidence that must be accumulated before a decision is made (boundary separation), and the time taken by nondecision processes. Results: Hypoglycemia resulted in a reduction of mean drift rate from 0.290 to 0.211, t(13) = 4.10, p     

Effect of acute hypoglycemia on visual information processing in adults with type 1 diabetes mellitus

Acute hypoglycemia in people with type 1 (insulin-dependent) diabetes mellitus causes general impairment in cognitive performance. The effects on more specific cognitive processes are less well defined. Acute hypoglycemia has been shown to impair visual information processing in nondiabetic human subjects and has now been examined in 16 adult subjects with type 1 diabetes. All subjects had normal visual acuity and no diabetic retinopathy, and their median (range) age was 24 (18-47) years with a median (range) duration of type 1 diabetes of 8 (2-18) years and a mean (SD) HbA1c of 8.5 (1.3)%. A hyperinsulinemic glucose clamp technique was used to maintain arterialized blood glucose at 5.0 mmol l(-1), and on separate test days, either euglycemia was continued or hypoglycemia (2.6 mmol l(-1)) was induced. During each condition subjects performed tests of visual processing and cognitive function. Hypoglycemia caused a significant disruption in general cognitive ability as assessed by digit symbol (p < 0.001) and trail-making B (p < 0.05) tasks. Conventional measures of visual acuity were unaffected by hypoglycemia, but visual information processing deteriorated significantly as indexed by inspection time (p < 0.005) and visual change detection (p < 0.01). Contrast sensitivity tended to deteriorate during hypoglycemia (p = 0.06). In conclusion, hypoglycemia impairs important aspects of early visual information processing and contrast sensitivity in adults with type 1 diabetes. Further research is needed to evaluate the functional relevance of such changes for everyday tasks that require the intake of visual information at speed and under conditions of low contrast.     

A (latent) Big Five personality model in 1915? A reanalysis of Webb's data.

In 1915 Edward Webb, working under Charles Spearman at University College London, reported a study of personality trait ratings of 194 trainee teachers. The original report found a single personality factor, which Webb named Persistence of Motives or w. Subsequent partial reanalyses and reinterpretations of Webb's data are reviewed and are found to be misleading. The quality of Webb's data is high; 2 raters assessed every student, and the raters' studies of the students' characters were unusually prolonged and intense. A new reanalysis of Webb's data analyzes 6- and 5-factor personality structures latent in the data set, which are judged by experts to be congruent with current 5-factor and other models of human personality trait structure. Therefore, the first, albeit latent, discovery of some currently recognized broad personality dimensions came from the department that is the birthplace of differential psychology. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

PASAT performance and the pattern of uptake of 99mTc-exametazime in brain estimated with single photon emission tomography

The effect of the paced auditory serial addition test (PASAT) on the regional uptake of 99mTc-exametazime was determined by single photon emission computed tomography. Twenty insulin-treated diabetic outpatients were scanned at rest and during the performance of the PASAT task using split-dose injection of tracer. When resting and activation scans were compared there were significant decreases in tracer uptake in the right anterior cingulate and left posterior cingulate areas during PASAT activation. The findings are compared with previous studies which had implicated the anterior cingulate area in the mechanisms of attention in humans and other animals. The potentially confounding role of anxiety during attentional tasks is discussed.     

"Age and sex differences in reaction time in adulthood: Results from the United Kingdom Health and Lifestyle Survey": Correction.

Reports an error in "Age and sex differences in reaction time in adulthood: Results from the United Kingdom Health and Lifestyle Survey" by Geoff Der and Ian J. Deary (Psychology and Aging, 2006[Mar], Vol 21[1], 62-73). In the article, the link to supplemental material is incorrect. The correct supplemental link follows. Supplemental materials are available online at http://dx.doi.org/10.1037/0882-7974.21.1.62.supp. (The following abstract of the original article appeared in record 2006-03906-007.) Reaction times (RTs) slow and become more variable with age. Research samples are typically small, biased, and of restricted age range. Consequently, little is known about the precise pattern of change, whereas evidence for sex differences is equivocal. The authors reanalyzed data for 7,130 adult participants in the United Kingdom Health and Lifestyle Survey, originally reported by F. A. Huppert (1987). The authors modeled the age differences in simple and 4-choice reaction time means and variabilities and tested for sex differences. Simple RT shows little slowing until around 50, whereas choice RT slows throughout the adult age range. The aging of choice RT variability is a function of its mean and the error rate. There are significant sex differences, most notably for choice RT variability. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Stability and change in intelligence from age 11 to ages 70, 79, and 87: The Lothian Birth Cohorts of 1921 and 1936.

Investigating the predictors of age-related cognitive change is a research priority. However, it is first necessary to discover the long-term stability of measures of cognitive ability because prior cognitive ability level might contribute to the amount of cognitive change experienced within old age. These two issues were examined in the Lothian Birth Cohorts of 1921 and 1936. Cognitive ability data were available from age 11 years when the participants completed the Moray House Test No. 12 (MHT). The Lothian Birth Cohort 1936 (LBC1936) completed the MHT a second time at age 70. The Lothian Birth Cohort 1921 (LBC1921) completed the MHT at ages 79 and 87. We examined cognitive stability and change from childhood to old age in both cohorts, and within old age in the LBC1921. Raw stability coefficients for the MHT from 11–70, 11–79, and 11–87 years were .67, .66, and .51, respectively; and larger when corrected for range restriction in the samples. Therefore, minimum estimates of the variance in later-life MHT accounted for by childhood performance on the same test ranged from 26–44%. This study also examined, in the LBC1921, whether MHT score at age 11 influenced the amount of change in MHT between ages 79 and 87. It did not. Higher intelligence from early life was apparently protective of intelligence in old age due to the stability of cognitive function across the lifespan, rather than because it slowed the decline experienced in later life. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

The effects of high altitude on choice reaction time mean and intra-individual variability: Results of the Edinburgh Altitude Research Expedition of 2008.

Objective: This study aimed to investigate the effects of high altitude on reaction time (RT) mean and intra-individual variability. Method: Ten students (6 men, 4 women) took a 4-choice RT test and had their vital signs and Lake Louise (LL) score measured on 21 occasions during the Edinburgh Altitude Research Expedition of 2008 to the Western Himalayas (max. altitude 5,565 m). Results: Linear mixed modeling revealed that mean RT was significantly impaired at altitudes above 4,000 m (p B = 1.97, 95% CI [0.70, 3.23], p B = ?1.50, 95% CI [?2.60, ?0.39], p B = ?2.16, 95% CI [?2.49, ?1.83], p B = 0.01801, 95% CI [0.0049, 0.0311], p B = ?0.00754, 95% CI [?0.0119, ?0.0032], p     

Caring in nursing: a multivariate analysis

The dimensions underlying the perceptions of caring among nurses were investigated using the Edinburgh Caring Dimensions Inventory (CDI). Exploratory and confirmatory factor analysis techniques were used. While there was a general caring factor on which the majority of the items in the CDI loaded, there were two separable major dimensions to caring, namely 'psychosocial aspects' and 'professional and technical aspects'. In addition, two smaller dimensions were identified that were both related to self-giving, and it is postulated that these refer, respectively, to appropriate and inappropriate self-giving in nursing.