Clinical associations of prenatal ischaemic white matter injury

Neuropathological examinations were carried out at necropsy on 274 cases of intrauterine death or neonatal death at or before three days after birth. Fifty six (20.4%) subjects had evidence of prenatal ischaemic brain damage. On review of the maternal case notes to ascertain antenatal clinical associations there was an increased incidence of intrauterine growth retardation, either based on birth weight for gestational age (odds ratio (OR) 2.0; 95% confidence interval (CI) 1.1 to 3.7) or diagnosed antenatally (OR 2.7; 95% CI 1.3 to 5.6). Oligohydramnios was also more common (OR 2.9; 95% CI 1.2 to 7.0). The association of intrauterine growth retardation and white matter damage remained after excluding fetuses with a major congenital anomaly (OR 2.4; 95% CI 1.1 to 5.1). The findings suggest that chronic intrauterine hypoxia may be associated with damage to cerebral white matter among fetuses and infants who die. The relation between ischaemic white matter damage and cerebral palsy among survivors remains speculative.     

Insiders Behaving Badly

This column goes beyond previous insider analyses to identify a framework for a taxonomy of insider threats including both malicious and inadvertent actions by insiders that put organizations or their resources at some risk. The framework includes factors reflecting the organization, the individual, the information technology system, and the environment.     

OXPath: A language for scalable data extraction, automation, and crawling on the deep web

The evolution of the web has outpaced itself: A growing wealth of information and increasingly sophisticated interfaces necessitate automated processing, yet existing automation and data extraction technologies have been overwhelmed by this very growth. To address this trend, we identify four key requirements for web data extraction, automation, and (focused) web crawling: (1) interact with sophisticated web application interfaces, (2) precisely capture the relevant data to be extracted, (3) scale with the number of visited pages, and (4) readily embed into existing web technologies. We introduce OXPath as an extension of XPath for interacting with web applications and extracting data thus revealed—matching all the above requirements. OXPath’s page-at-a-time evaluation guarantees memory use independent of the number of visited pages, yet remains polynomial in time. We experimentally validate the theoretical complexity and demonstrate that OXPath’s resource consumption is dominated by page rendering in the underlying browser. With an extensive study of sublanguages and properties of OXPath, we pinpoint the effect of specific features on evaluation performance. Our experiments show that OXPath outperforms existing commercial and academic data extraction tools by a wide margin.     

Searching for You (review of Googling Security: How Much Does Google Know About You? by G. Conti; 2008) [Book reviews]

This book warns readers about the proliferation of data capture and the degree to which we're tracked and traced on the Web. In ten heavily illustrated chapters, the author explains how our data are captured, retained, and shared (often for a price) with third parties. The author dedicates a chapter to ways of addressing the threat. He suggests methods for controlling cookies, diffusing or eliminating disclosures, encrypting important data, protecting a network address, and using policy as well as technical devices to minimize data capture and retention.     

A Work‐In‐Process Literature Review: Incorporating Social Media in Risk and Crisis Communication

This work‐in‐process literature review gives an overview of recent insight in the incorporation of social media in risk and crisis communication. By marrying literature and examples of social media use with best practices in risk and crisis communication, this study demonstrates how communicators can embrace social media tools to better manage a risk or crisis. Best practices in risk and crisis communication are summarized, examples of social media tools used to manage risks and crises are expounded, and recommendations for practitioners are provided to incorporate social media tools in risk and crisis communication.     

Environmental life-cycle inventory of detergent-grade surfactant sourcing and production

Life-cycle inventories were compiled to characterize natural resource requirements and environmental emissions associated with the sourcing and production of selected, detergent-grade surfactants and surfactant feedstocks. Petrochemical surfactant types examined were linear alkylbenzene sulfonate, alcohol sulfate (AS), alcohol ethoxylate (AE) and alcohol ethoxylate sulfate (AES). Oleochemical surfactants derived from palm oil, palm kernel oil and inedible tallow were AS, AE, AES and (for palm oil and tallow) methyl ester sulfonate. It was determined that natural resource requirements were primarily related to the source of feedstock and secondarily to surfactant type. Likewise, the composition and mass of atmospheric, aqueous and solid emissions were principally determined by feedstock source. Energy requirements varied as a function of both feedstock and surfactant type. The inventories do not support fundamental shifts in surfactant usage or feedstock sourcing on the basis of environmental concerns, as no single surfactant or feedstock was identified as superior across all resource and emissions criteria examined. The data provide baselines for evaluating opportunities for resource optimization, pollution prevention and waste minimization within each production technology surveyed.     

The in vitro and in vivo investigation of inhaled migraine therapies using a novel aerosol delivery system consisting of an air pressurized capsule device (APCD) in combination with a pMDI spacer for endotracheal dosing into beagle dogs

Abstract

Context: Aerosol delivery to animals in preclinical settings has historically been very challenging, requiring the use of techniques, such as intratracheal instillation and dry powder insufflation, that are somewhat invasive, inefficient and not representative of clinical inhalation.

Objective: The objective of this work is to develop a system to deliver dry powder to dogs in an efficient and effective manner for the study of new anti-migraine compounds in development.

Materials and methods: The new device uses a metered aliquot of a dry gas to force dry powder drug from a pre-filled HPMC capsule into an AeroChamber® spacer for subsequent inhalation by the animal.

Results: The delivery of two invesigational migraine drugs via the new device was assessed in vitro using abbreviated Andersen cascade impaction and showed the device is capable of generating a reproducible delivered dose of up to ～68% with more than 50% of the dose in the respirable range. In vivo studies have also been performed showing that this device effectively delivered the migraine drugs to spontaneously breathing dogs using a proprietary validated dog inhalation model.

Discussion: Results confirmed that the air pressurized capsule device (APCD) was effective in delivering the APIs to lungs of the animals. The in vivo data verified the advantages of inhaled delivery over oral delivery for this class of drugs and were used to establish the cardiopulmonary and respiratory side effect liability profile for these compounds.

Conclusions: This work has demonstrated the utility of this device for quick and accurate screening of prospective drug candidates, representing a significant improvement in ease of use and reprodicibility over current delivery methods.     

Assessing and managing the benefits of enterprise systems: the business manager's perspective

This paper focuses on the benefits that organizations may achieve from their investment in enterprise systems (ES). It proposes an ES benefit framework for summarizing benefits in the years after ES implementation. Based on an analysis of the features of enterprise systems, on the literature on information technology (IT) value, on data from 233 enterprise systems vendor‐reported stories published on the Web and on interviews with managers of 34 organizations using ES, the framework provides a detailed list of benefits that have reportedly been acquired through ES implementation. This list of benefits is consolidated into five benefits dimensions: operational, managerial, strategic, IT infrastructure and organizational, and illustrated using perceived net benefit flow (PNBF) graphs. In a detailed example, the paper shows how the framework has been applied to the identification of benefits in a longitudinal case study of four organizations.