Nutritional components as mitigators of cellular senescence in organismal aging: a comprehensive review

Food Science and Biotechnology - The process of cellular senescence is rapidly emerging as a modulator of organismal aging and disease. Targeting the development and removal of senescent cells is...     

A novel adaptive sampling based methodology for feasible region identification of compute intensive models using artificial neural network

Identification of feasible region of operations in multivariate processes is a problem of interest in several fields. This is particularly challenging when the process model is black-box in nature and/or is computationally expensive, as analytical solutions are not available and the number of possible model evaluations is limited. An efficient methodology is required to identify samples where the model is evaluated for developing a computationally efficient surrogate model. In this work, an artificial neural network based surrogate model is proposed which is integrated with a statistical-based approach (Jack-knifing) to estimate the variance of the surrogate model prediction. This allows implementation of an adaptive sampling approach where new samples are identified close to the feasible region boundary or in regions of high prediction uncertainty. The proposed approach performs better than a previously published kriging based method for different dimensionality case studies.     

Low thermal conductivity in porous SiC–SiO2–Al2O3–TiO2 ceramics induced by multiphase thermal resistance

The introduction of multiple heterogeneous interfaces in a ceramic is an efficient way to increase its thermal resistance. Novel porous SiC–SiO₂–Al₂O₃–TiO₂ (SSAT) ceramics were fabricated to achieve multiple heterogeneous interfaces by sintering equal volumes of SiC, SiO₂, Al₂O₃, and TiO₂ compacted powders with polysiloxane as a bonding phase and carbon as a template at 600 °C in air. The porosity could be controlled between 66% and 74% by adjusting the amounts of polysiloxane and the carbon template. The lowest thermal conductivity (0.059 W/(m·K) at 74% porosity) obtained in this study is an order of magnitude lower than those (0.2–1.3 W/(m·K)) of porous monolithic SiC, SiO₂, Al₂O₃, and TiO₂ ceramics at an equivalent porosity. The typical specific compressive strength value of the porous SSAT ceramics at 74% porosity was 3.2 MPa cm³/g.     

A Survey of Various Schedulers Used for Fair Bandwidth Allocation in WiMAX: IEEE 802.16

ABSTRACT

Wireless Interoperability for Multiple Access (WiMAX) is one of the emerging fields of high-speed wireless communication that has enormous capabilities due to its range and the connection speed. Like wireless local area networks (LANs), WiMAX networks implement multiple quality of service (QoS) frameworks at the Media Access Control (MAC) level for assured data, voice, and video services. The question of ensuring QoS is basically how to distribute available resources to users in order to satisfy QoS parameters such as latency, jitter and throughput requirements. IEEE 802.16 standard does not have any particular guidelines on scheduling of incoming and outgoing data. This has caught the attention of researchers working on WiMAX. This article discusses the various issues in WiMAX along with a classification of various scheduling approaches based upon the type of scheduler for the sake of better understanding the scheduling problem and analyzing various available theories.     

An isogeometric independent coefficients (IGA-IC) reduced order method for accurate and efficient transient nonlinear heat conduction analysis

This article develops an isogeometric independent coefficients (IGA-IC) reduced order method for transient nonlinear heat conduction analysis. Herein, we first exactly represent the geometric model via isogeometric analysis (IGA), and therein provide an accurate solution for the semi-discretized equations. Next, our proposed GSSSS-1 time-stepping framework is employed to solve the transient nonlinear temperature in space and time domains. We advance our independent coefficients (IC) reduced order method to efficiently solve IGA-based transient nonlinear heat conduction problems. We extend the IC method to significantly reduce the original full IGA-discretized formulations and calculate the reduced equilibrium formulations in each Newton–Raphson iteration. Thereby, hugely improving the efficiency and guaranteeing the accuracy simultaneously. Illustrative numerical examples validate this proposed IGA-IC method is reliable, accurate, and efficient; especially, the larger the scale of the problem, the more advantages the proposed IGA-IC will inherit.     

Study of physicochemical properties of flutamide-loaded Ocimum basilicum microspheres with ex vivo mucoadhesion and in vitro drug release

Drug which shows extensive first pass effect is difficult task that, needs to be solved by formulators in the pharmaceutical science. The low oral bioavailability (49%) of flutamide may be due to poor wettability, low aqueous solubility and extensive first pass effect. The aim of present investigation was to prepare flutamide loaded microspheres and incorporate it into suppositories for rectal delivery to avoid first pass effect and enhance residence time. Flutamide loaded mucoadhesive microspheres of Ocimum Basilicum mucilage (OBM) were prepared using spray drying and characterized by percent production yield, encapsulation efficiency, particle size, zeta potential, polydispersity index, DSC, SEM, XRPD, in vitro drug release and stability studies. Moreover, ex vivo mucoadhesion was investigated using falling liquid film technique to determine the adhesion of microspheres to sheep rectal mucosa. The microspheres had nearly spherical shape and size about 2.53?μm. The encapsulation efficiency and mucoadhesion of optimized formulation MBF10 were found to be 69.6?±?2.3% and 89.01?±?2.18%, respectively. Percent CDR of optimized flutamide loaded mucoadhesive microspheres was found to be 88.7?±?1.3 at 7?h. In conclusion, OBM microparticles based suppository could be used to deliver drug through rectal delivery.     

Effects of DEM Source,Spatial Resolution and Drainage Area Threshold Values on Hydrological Modeling

Water Resources Management - Automated computation of hydrological and morphometric parameters of any watershed are not only depended on Digital Elevation Model (DEM) resolution but also affected...     

Synthesis of magnetic nanocomposite microparticles for binding of chlorinated organics in contaminated water sources

In this work, the development of novel magnetic nanocomposite microparticles (MNMs) via free radical polymerization for their application in the remediation of contaminated water is presented. Acrylated plant-based polyphenols, curcumin multiacrylate (CMA) and quercetin multiacrylate (QMA), were incorporated as functional monomers to create high affinity binding sites for the capture of polychlorinated biphenyls (PCBs), as a model pollutant. The MNMs were characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy, dynamic light scattering, and UV–visible spectroscopy. The affinity of these novel materials for PCB 126 was evaluated and fitted to the nonlinear Langmuir model to determine binding affinities (K_D). The results suggest the presence of the polyphenolic moieties enhances the binding affinity for PCB 126, with K_D values comparable to that of antibodies. This demonstrates that these nanocomposite materials have promising potential as environmental remediation adsorbents for harmful contaminants.     

A Broadband Dual Circularly Polarized Compact Printed Monopole Antenna

Wireless Personal Communications - Now-a-days the most common pretentious disease is the lung cancer, which has become more prevalent in the world that primarily infects the pulmonary nodules of...