Environmental Enrichment Enhances Cav 2.1 Channel-Mediated Presynaptic Plasticity in Hypoxic–Ischemic Encephalopathy

Hypoxic–ischemic encephalopathy (HIE) is a devastating neonatal brain condition caused by lack of oxygen and limited blood flow. Environmental enrichment (EE) is a classic paradigm with a complex stimulation of physical, cognitive, and social components. EE can exert neuroplasticity and neuroprotective effects in immature brains. However, the exact mechanism of EE on the chronic condition of HIE remains unclear. HIE was induced by a permanent ligation of the right carotid artery, followed by an 8% O₂ hypoxic condition for 1 h. At 6 weeks of age, HIE mice were randomly assigned to either standard cages or EE cages. In the behavioral assessments, EE mice showed significantly improved motor performances in rotarod tests, ladder walking tests, and hanging wire tests, compared with HIE control mice. EE mice also significantly enhanced cognitive performances in Y-maze tests. Particularly, EE mice showed a significant increase in Ca_v 2.1 (P/Q type) and presynaptic proteins by molecular assessments, and a significant increase of Ca_v 2.1 in histological assessments of the cerebral cortex and hippocampus. These results indicate that EE can upregulate the expression of the Ca_v 2.1 channel and presynaptic proteins related to the synaptic vesicle cycle and neurotransmitter release, which may be responsible for motor and cognitive improvements in HIE.     

Monascus-fermented grain vinegar enhances glucose homeostasis through the IRS-1/PI3K/Akt and AMPK signaling pathways in HepG2 cell and db/db mice

Food Science and Biotechnology - MV was reported to have beneficial effects in ameliorating insulin resistance in db/db mice, but the intrinsic mechanisms for glucose homeostasis are unclear. This...     

A robust loop-closure method for visual SLAM in unstructured seafloor environments

This paper addresses the problem of visual simultaneous localization and mapping (SLAM) in an unstructured seabed environment that can be applied to an unmanned underwater vehicle equipped with a single monocular camera as the main measurement sensor. Monocular vision is regarded as an efficient sensing option in the context of SLAM, however it poses a variety of challenges when the relative motion is determined by matching a pair of images in the case of in-water visual SLAM. Among the various challenges, this research focuses on the problem of loop-closure which is one of the most important issues in SLAM. This study proposes a robust loop-closure algorithm in order to improve operational performance in terms of both navigation and mapping by efficiently reconstructing image matching constraints. To demonstrate and evaluate the effectiveness of the proposed loop-closure method, experimental datasets obtained in underwater environments are used, and the validity of the algorithm is confirmed by a series of comparative results.     

Novel SrCo1 − 2x(Fe,Nb)xO3 − δ (x = 0.05, 0.10) oxides targeting CO2 capture and O2 enrichment: Structural stability and oxygen sorption properties

The novel Fe/Nb co-doped SrCo_1 ? 2x(Fe,Nb)_xO_3 ? δ (x = 0.05, 0.10) perovskite oxides were synthesized by the solid-state method. Structural and chemical stability of the SrCo_1 ? 2x(Fe,Nb)_xO_3 ? δ (x = 0.05, 0.10) oxides were studied by differential scanning calorimetry (DSC), thermogravimetric analysis (TG) and X-ray diffraction (XRD). The results demonstrated that the structural and chemical stability of the Fe/Nb co-doped SrCo_1 ? 2x(Fe,Nb)_xO_3 ? δ (x = 0.05, 0.10) is improved significantly. The oxygen sorption properties of the SrCo_1 ? 2x(Fe,Nb)_xO_3 ? δ (x = 0.05, 0.10) oxides were investigated between 300–900 °C in air, and the high oxygen sorption capacity of 11.5 and 10.3 mL O₂ (STP)/g oxide, respectively, are obtained.     

HF RFID Reader Antenna with Loop Switch for Avoiding Magnetic Coupling

This paper studies the magnetic coupling between two adjacent loop antennas that are parallel to each other in a plane and presents a new practical method to avoid the resulting magnetic coupling interference. The study focuses on the high frequency radio‐frequency identification (RFID) system for casino applications, where several loop antennas are closely built into a game table to monitor gaming chips. In this case, neighboring loop antennas may severely interfere with each other by magnetic coupling, which leads to the malfunction of the RFID system. In this paper, we present a practical loop antenna with a new loop switch circuit for avoiding magnetic coupling. The loop switch circuit is integrated with a matching circuit and automatically operated by using an interrogating signal from a reader. We verified the validity of the proposed design by showing that an RFID reader with the proposed antenna can exactly and separately read the gaming chips placed on the different betting zones of a game table.     

Investigation of organic n-type field-effect transistor performance on the polymeric gate dielectrics

We report a copper hexadecafluorophthalocyanine (F₁₆CuPc) based n-type organic field-effect transistor (OFET) with polymeric gate dielectrics with different physical/electrical properties. The gate dielectrics are four types of cross-linked poly(4-vinylphenol) and newly prepared poly(4-phenoxy methyl styrene) and those are characterized based on surface tension, leakage current and capacitance. The performance of F₁₆CuPc OFETs with those gate dielectrics was compared. We found that the composition of the gate dielectrics and the interfacial interaction of F₁₆CuPc with the gate dielectric play a decisive role in the performance of OFETs. The effect of physical/electrical properties, composition and processing condition of the gate dielectrics on the device performance was investigated.     

Hierarchical spatial relation based on a contiguity graph

Autonomous agents traversing a natural space need to be knowledgeable of its space configuration. The existing space models in geographic information systems and robotics, however, deal with only the topological relations among numerous types of spatial relations. We aim to develop an enhanced space model that elaborates the spatial relations with respect to their relevant physical relations. Specifically, the spatial relations in a space configuration are further characterized with the gravitation as a potential factor to affect the space configuration. The resulting space model is capable of capturing an extended set of spatial relations over existing models such as a four‐intersection model. © 2005 Wiley Periodicals, Inc. Int J Int Syst 20: 867–892, 2005.     

Evaluation of external quantum efficiency of a 12.35% tandem solar cell comprising dye-sensitized and CIGS solar cells

A tandem solar cell is constructed by series connection of a semi-transparent dye-sensitized solar cell (DSSC) as a top cell and a Cu(In, Ga)Se₂ (CIGS) solar cell as a bottom cell, where the isolated DSSC and CIGS cells show the conversion efficiency of 8.27% and 11.71%, respectively. The DSSC/CIGS tandem cell exhibits the improved conversion efficiency of 12.35% with photocurrent density of 14.1 mA/cm², open-circuit voltage of 1.435 V and fill factor of 0.61. External quantum efficiency (EQE) of the tandem cell is investigated under DC and AC modes. EQE of the isolated DSSC and CIGS cell can be measured by either DC mode or AC mode, whereas EQE for the tandem cell is detected only under AC mode with bias light. Bias light intensity is found to play the crucial role in determining the precise EQE of the tandem cell. At the given chopping frequency as low as 10 Hz, the measured EQE at bias light corresponding to 1 sun intensity is consistent with the simulated EQE data.