A radiomics pipeline dedicated to Breast MRI: validation on a multi-scanner phantom study

Magnetic Resonance Materials in Physics, Biology and Medicine - Quantitative analysis in MRI is challenging due to variabilities in intensity distributions across patients, acquisitions and...     

Platinum(II) Complexes Bearing Triphenylphosphine and Chelating Oximes: Antiproliferative Effect and Biological Profile in Resistant Cells

Platinum(II) complexes of the type [Pt(Cl)(PPh₃){(κ²-N,O)-(1{C(R)=N(OH)-2(O)C₆H₄})}] with R=Me, H, ( 1 and 2 ) were synthesized and characterized. Single-crystal X-ray diffraction confirmed the proposed (SP4-3) configuration for 1 . Study of the antiproliferative activity, performed on a panel of human tumor cell lines and on mesothelial cells, highlighted complex 2 as the more effective. In particular, it showed a remarkable cytotoxicity in ovarian carcinoma cells (A2780) and interestingly, a significant antiproliferative effect on cisplatin resistant cells (A2780cis). Investigation into the intracellular mechanism of action demonstrated that 2 had a lower ability to platinate DNA than did cisplatin, which was taken as reference, and a notably higher uptake in resistant cells. A significant accumulation in mitochondria, along with the ability to induce concentration-dependent mitochondrial membrane depolarization and intracellular reactive oxygen species production, allowed us to propose a mitochondrion-mediated pathway as responsible for the interesting cytotoxic profile of complex 2 .     

Maximizing Convergence Speed for Second Order Consensus in Leaderless Multi-Agent Systems

The paper deals with the consensus problem in a leaderless network of agents that have to reach a common velocity while forming a uniformly spaced string. Moreover, the final common velocity (reference velocity) is determined by the agents in a distributed and leaderless way. Then, the consensus protocol parameters are optimized for networks characterized by a communication topology described by a class of directed graphs having a directed spanning tree, in order to maximize the convergence rate and avoid oscillations. The advantages of the optimized consensus protocol are enlightened by some simulation results and comparison with a protocol proposed in the related literature. The presented protocol can be applied to coordinate agents such as mobile robots, automated guided vehicles (AGVs) and autonomous vehicles that have to move with the same velocity and a common inter-space gap.      

The influence of urban and natural amenities on second home prices

This paper estimates a spatial hedonic model to examine the influence of urban and natural amenities on second home prices in south Sweden, incorporating local and regional heterogeneity. With the results obtained in this paper, several important relationships between amenities and second home prices are revealed and price formation in this particular study region is indicated to be strongly related to place-specific factors, regional context and amenities. Key findings show that natural amenities have a significant influence on pricing of second homes when located in regions classified as rural, whereas access to an attractive local house market is shown to be more important for prices of urban second homes.     

Efficient driver drowsiness detection at moderate levels of drowsiness

Previous research on driver drowsiness detection has focused primarily on lane deviation metrics and high levels of fatigue. The present research sought to develop a method for detecting driver drowsiness at more moderate levels of fatigue, well before accident risk is imminent. Eighty-seven different driver drowsiness detection metrics proposed in the literature were evaluated in two simulated shift work studies with high-fidelity simulator driving in a controlled laboratory environment. Twenty-nine participants were subjected to a night shift condition, which resulted in moderate levels of fatigue; 12 participants were in a day shift condition, which served as control. Ten simulated work days in the study design each included four 30-min driving sessions, during which participants drove a standardized scenario of rural highways. Ten straight and uneventful road segments in each driving session were designated to extract the 87 different driving metrics being evaluated. The dimensionality of the overall data set across all participants, all driving sessions and all road segments was reduced with principal component analysis, which revealed that there were two dominant dimensions: measures of steering wheel variability and measures of lateral lane position variability. The latter correlated most with an independent measure of fatigue, namely performance on a psychomotor vigilance test administered prior to each drive. We replicated our findings across eight curved road segments used for validation in each driving session. Furthermore, we showed that lateral lane position variability could be derived from measured changes in steering wheel angle through a transfer function, reflecting how steering wheel movements change vehicle heading in accordance with the forces acting on the vehicle and the road. This is important given that traditional video-based lane tracking technology is prone to data loss when lane markers are missing, when weather conditions are bad, or in darkness. Our research findings indicated that steering wheel variability provides a basis for developing a cost-effective and easy-to-install alternative technology for in-vehicle driver drowsiness detection at moderate levels of fatigue.     

How to Build Up an Infrastructure for Intercultural Usability Engineering

Siemens is a global enterprise that sells its products in more than 190 countries throughout the world. This internationalization of products means more than just translating the operating instructions and making changes to formats. True adaptation goes much deeper and takes into account different requirements in terms of functionality. This article starts by defining the term culture and then considers the requirements that have to be met in the context of intercultural usability engineering. Taking the establishment of usability laboratories in Beijing, China and Princeton, New Jersey as examples, the article then presents the challenges facing international cooperation and possible solutions, taking a detailed look at differences in the infrastructure, at key qualifications in international cooperation, and at the development of appropriate test methods.     

Reticulated Porous Foam Ceramics with Different Surface Chemistries

The aim of this study was to discuss the influence of different filter surface chemistries on the properties of foam filters. For reliable results, it is essential to ensure comparable structural properties (cell size and strut thickness) for all different surface chemistries (Al₂O₃, MgAl₂O₄, 3Al₂O₃·2SiO₂, SiO₂, and TiO₂) possess the same structural properties (cell size and strut thickness). Filters made of 100% of the investigated materials and alumina skeletons coated with the investigated materials were prepared. The coated alumina samples were sintered in one and two steps. The processing route with two sintering steps resulted in improved mechanical properties and comparable shrinkage and strut thickness. The 100% bulk foams possessed different pore sizes due to the differences of the material shrinkage. In this study, a comparison of the experimental investigated properties of the ceramic foam filters and the theoretically calculated values for foam materials derived from the bulk material properties is established.