Safe-by-Design: Stakeholders’ Perceptions and Expectations of How to Deal with Uncertain Risks of Emerging Biotechnologies in the Netherlands

Advanced gene editing techniques such as Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/Cas have increased the pace of developments in the field of industrial biotechnology. Such techniques imply new possibilities when working with living organisms, possibly leading to uncertain risks. In the Netherlands, current policy fails to address these uncertain risks because risk classification is determined process-wise (i.e., genetically modified organism [GMO] and non-GMO), there is a strong focus on quantifiable risks, and the linearity within current governance (science–policy–society) hinders iterative communication between stakeholders, leaving limited room to anticipate uncertainties at an early stage of development. A suggested concept to overcome these shortcomings is the Safe-by-Design (SbD) approach, which, theoretically, allows stakeholders to iteratively incorporate safety measures throughout a technology's development process, creating a dynamic environment for the anticipation of uncertain risks. Although this concept originates from chemical engineering and is already widely applied in nanotechnology, for the field of biotechnology, there is no agreed upon definition yet. To explore the possibilities of SbD for future governance of biotechnology, we should gain insight in how various stakeholders perceive notions of risk, safety, and inherent safety, and what this implies for the applicability of SbD for risk governance concerning industrial biotechnology. Our empirical research reveals three main themes: (1) diverging expectations with regard to safety and risks, and to establish an acceptable level of risk; (2) different applications of SbD and inherent safety, namely, product- and process-wise; and (3) unclarity in allocating responsibilities to stakeholders in the development process of a biotechnology and within society.     

Urban and peri-urban agriculture and its implication on food and nutrition insecurity in northern Ghana: a socio-spatial analysis along the urban–rural continuum

Food and nutrition insecurity remains a challenge in sub-Saharan Africa. Several studies have examined food and nutrition insecurity in urban or rural areas but have not captured the whole continuum. Between November and December 2013, 240 households were surveyed along the urban–rural continuum in Northern Ghana. The study objective was to understand the socio-spatial dynamics of household food and nutrition insecurity and to investigate the role played by urban, peri-urban and rural agriculture. The study found that there was more involvement in agriculture in rural areas compared to peri-urban areas and urban areas. Households from urban areas were more food insecure (HFIAS >?11) compared to their counterparts in peri-urban and the rural areas. Stunting increased by 3.4 times (p?=?0.048) among households located in the peri-urban area. Wasting was reduced by 0.16 times among household that produced staple food or vegetables (p?=?0.011). Overweight was reduced by 0.04 times among households that produced livestock (p?=?0.031). The results reveal a socio-spatial dimension of food and nutrition insecurity that is related to agricultural activities.     

Promoting work ability and well-being in hospital nursing: the interplay of age, job control, and successful ageing strategies

Previous research shows that work ability of nurses decreases with age. In our study we therefore addressed the following questions: Do successful ageing strategies at work in terms of selection, optimization, and compensation (SOC) support the work ability of nurses? Does SOC mediate the relationship between job control (i.e., decision opportunities at work) and work ability? Does the mediation differ between age-groups? 438 nurses (Age Range 21-63 years) completed a questionnaire in the course of an employee survey. Results show that SOC is positively related with work ability. The positive effect of job control on work ability is significantly mediated by SOC. There are stronger mediating effects for elder nurses than for younger nurses. Results indicate that the interplay of job control and SOC at work helps to maintain the work ability of nurses in nursing care.     

Ethnic segregation in context: Social discrimination among native Dutch pupils and their ethnic minority classmates

Social discrimination, defined as the relative preference for intra-ethnic over inter-ethnic relationships, was studied in pupils’ networks in Dutch secondary school classes. While native Dutch pupils (ethnic majority members) mainly named fellow majority members, ethnic minority members reported ties with as many majority as minority members. Considering the ethnic composition of the classroom, however, majority members discriminated less than minorities. No strong effect of classroom ethnic composition on social discrimination was found, whereas neighborhood composition was shown to clearly influence social discrimination: ethnic minority members were more, and majority members less inclined to discriminate in neighborhoods with more ethnic presence.     

The Workers' Compensation System in Victoria: Who Takes the Blame?

Four years after its inception, Workcare, the Victorian Government's new workers' compensation scheme, has failed to live up to its promise. Recent reforms have concentrated on identifying groups responsible for the ‘rorts’ and cost ‘blowouts’ of the scheme. It is argued that although this sort of intervention might make economic sense, it continues a tradition of scapegoating individual workers rather than trying to analyse the complex workings of such schemes. Several of the assumptions underlying Workcare (and similar systems) are discussed in order to demonstrate the potential for failure in any benefits delivery system based on status rather than need.     

Stress Hormone Changes and Marital Conflict: Spouses’ Relative Power Makes a Difference

We investigated the impact of relative marital power on 72 newlywed couples’ endocrinological responses to marital conflict. Marital power was determined by comparing spouses’ reports of dependent love for one another. Less powerful spouses displayed elevated adrenocorticotropic hormone (ACTH) responses to a conflict discussion. Shared power appeared to have a beneficial effect on wives’ but not husbands’ ACTH responses. Spouses’ cortisol levels declined over time, except for wives who were less powerful and for husbands who shared power with their wives. Conflict behaviors did not differ as a function of this marital power index. These data suggest that relative levels of general emotional power in relationships may play an important role in spouses’ physiological responses to marital conflict.     

Leveraging middle managers’ brokerage for corporate entrepreneurship: The role of multilevel social capital configurations

Building on recent efforts to bring a socio-political perspective to social capital research, we develop and test a multilevel framework that explains why middle managers who occupy brokerage positions differ in their ability and willingness to engage in entrepreneurial behavior. More specifically, we provide a contextualized understanding of the links among middle managers' brokerage, their political-support ties, and their personal initiative. Results derived from data on 383 middle managers and 72 top managers in 34 business units indicate that political-support ties with top managers strengthen the relationship between middle managers’ brokerage and personal initiative. However, this positive effect depends on the social capital resources available in the focal business unit. It is attenuated in business units with a supportive and trusting social context and amplified in business units with high levels of internal connectedness. By uncovering these incompatibilities and complementarities, our study demonstrates the value of accounting for different social capital configurations and the interplay of their inherent social capital resources when examining the effects of brokerage on corporate entrepreneurship.     

A theory and verities of market place behaviour

This study questions traditional notions of competitive economic behaviour from a theoretical perspective of social psychology and systems theory. Inter alia these approaches suggest, firstly, that economic relationships are simply an aspect of broader social relationships and are likely to be characterised by cooperation rather than competitiveness and the likelihood of conflict. Secondly, it is suggested that the conditions required for market participants to he “fully informed” would not he evident because of the potential instability of such a communications network or system.These broad hypotheses are examined by measuring aspects of communications and business behaviour in a wholesale agricultural market. The data. which are analysed by network and correlational procedures, support the hypotheses.