数据挖掘技术在连锁药店管理中的应用研究

以亳州盖福祥连锁药店为例,利用关联规则对数据库中药品的销售信息进行挖掘及利用NK—means聚类算法对顾客忠诚度进行聚类分析研究,找出影响连锁药店盈利的主要因素,为连锁药店改进营销策略、提高服务质量提供参考依据。     

Influence of caffeine on perception of effort,metabolism and exercise performance following a high-fat meal

Abstract

This study examined the effects of caffeine, co-ingested with a high fat meal, on perceptual and metabolic responses during incremental (Experiment 1) and endurance (Experiment 2) exercise performance. Trained participants performed three constant-load cycling tests at approximately 73% of maximal oxygen uptake ([Vdot]O_2max) for 30 min at 20°C (Experiment 1, n = 8) and to the limit of tolerance at 10°C (Experiment 2, n = 10). The 30 min constant-load exercise in Experiment 1 was followed by incremental exercise (15 W · min^?1) to fatigue. Four hours before the first test, the participants consumed a 90% carbohydrate meal (control trial); in the remaining two tests, the participants consumed a 90% fat meal with (fat + caffeine trial) and without (fat-only trial) caffeine. Caffeine and placebo were randomly assigned and ingested 1 h before exercise. In both experiments, ratings of perceived leg exertion were significantly lower during the fat + caffeine than fat-only trial (Experiment 1: P < 0.001; Experiment 2: P < 0.01). Ratings of perceived breathlessness were significantly lower in Experiment 1 (P < 0.01) and heart rate higher in Experiment 2 (P < 0.001) on the fat + caffeine than fat-only trial. In the two experiments, oxygen uptake, ventilation, blood [glucose], [lactate] and plasma [glycerol] were significantly higher on the fat + caffeine than fat-only trial. In Experiment 2, plasma [free fatty acids], blood [pyruvate] and the [lactate]:[pyruvate] ratio were significantly higher on the fat + caffeine than fat-only trial. Time to exhaustion during incremental exercise (Experiment 1: control: 4.9, s = 1.8 min; fat-only: 5.0, s = 2.2 min; fat + caffeine: 5.0, s = 2.2 min; P > 0.05) and constant-load exercise (Experiment 2: control: 116 (88 – 145) min; fat-only: 122 (96 – 144) min; fat + caffeine: 127 (107 – 176) min; P > 0.05) was not different between the fat-only and fat + caffeine trials. In conclusion, while a number of metabolic responses were increased during exercise after caffeine ingestion, perception of effort was reduced and this may be attributed to the direct stimulatory effect of caffeine on the central nervous system. However, this caffeine-induced reduction in effort perception did not improve exercise performance.     

An exercise protocol that simulates the activity patterns of elite junior squash

Abstract

Squash is a popular racket sport that requires intermittent activity with frequent bursts of near maximal-intensity exercise. Consequently, effective physiological and thermoregulatory responses are important contributors to performance during squash match-play. Controlled field-based simulation protocols have been introduced in a growing number of sports, which allow sports scientists to investigate changes in physiology and the efficacy of various interventions in sport-specific contexts. This study aimed to develop an exercise protocol that simulates the physiological requirements of elite squash match-play. Eight elite junior squash players (age 16.2 ± 0.8 years, height 1.76 ± 0.06 m, body mass 61.3 ± 5.9 kg; mean ± s) completed the following in a randomized order: (1) a squash match against a player of similar standard and (2) a squash-specific incremental exercise protocol (multistage squash test [MST]) followed by the squash simulation protocol (SSP). The multistage squash test was continued for 18.0 ± 1.0 min and elicited near maximal post-MST heart rates, blood lactate concentrations and ratings of perceived exertion (198 ± 9 beats · min^?1, 5.7 ± 1.7 mmol · l^?1 and 18 ± 1, respectively). The SSP was 12.2 min in length compared with mean game length during competitive matches of 10.0 ± 1.6 min (P = 0.27). Peak heart rates were similar during the SSP and match-play (192 ± 11 and 189 ± 6 beats · min^?1, respectively; P = 0.44). Mean exercising heart rates were similar during the SSP (180 ± 8 beats · min^?1) and match-play (179 ± 13 beats · min^?1; P = 0.73). Peak blood lactate concentrations during the SSP and match-play were 3.5 ± 1.5 and 2.4 ± 1.2 mmol · l^?1 (P = 0.07), respectively. Peak ratings of perceived exertion during the SSP and match-play were similar (17 ± 2 and 17 ± 2, respectively; P = 0.64). It was concluded that the SSP closely replicated the demands of squash match-play in elite junior squash players. Furthermore, the SSP provides coaches and scientific support staff with a controlled squash-specific exercise protocol that has potential application in the objective investigation of a range of interventions such as training programmes, nutritional supplements and strategies to maintain core body temperature.     

Right-left digit ratio (2D:4D) and maximal oxygen uptake

A low digit ratio (2D:4D) and low 2D:4D in the right compared with the left hand (right-left 2D:4D) are thought to be determined by high in utero concentrations of testosterone, and are related to "masculine" traits such as aggression and performance in sports like running and rugby. Low right-left 2D:4D is also related to sensitivity to testosterone as measured by the number of cytosine-adenine-guanine triplet repeats in exon 1 of the androgen receptor gene. Here we show that low right-left 2D:4D is associated with high maximal oxygen uptake (VO2(max)), high velocity at VO2(max), and high maximum lactate concentration in a sample of teenage boys. We suggest that low right-left 2D:4D is linked to performance in some sports because it is a proxy of high sensitivity to prenatal and maybe also circulating testosterone and high VO2(max).     

Digit ratio (2D:4D) and performance in elite rugby players

The relative length of the second and fourth digits (2D:4D) is a putative marker for prenatal testosterone. Low 2D:4D has been reported to correlate with high performance in sport in general. Here, for the first time, we examine the relationship between 2D:4D and performance in elite rugby players. The 44 players (28 forwards, 16 backs) were drawn from the Ospreys Rugby Union Club and 44 age-matched controls. The measures of performance comprised age-adjusted number of international performances (caps) for Wales, a comparison of coaches' first-choice League team with others, and the number of tries scored by backs in club matches. Compared with controls, players were larger and had lower 2D:4D for the right and left hand. With regard to number of caps, players with low 2D:4D in their right hand and low right 2D:4D compared with their left (right?-?left 2D:4D difference) had high numbers of caps. First-choice players did not differ significantly from second-choice players in their 2D:4D but they did have a lower right?-?left 2D:4D difference than second-choice players. Low right 2D:4D and low right?-?left 2D:4D difference were significantly linked with large numbers of tries. We conclude that low right 2D:4D and low right?-?left 2D:4D difference are predictors of high rugby performance.     

A combined insulin reduction and carbohydrate feeding strategy 30 min before running best preserves blood glucose concentration after exercise through improved fuel oxidation in type 1 diabetes mellitus

In this study, we examined the glycaemic and fuel oxidation responses to alterations in the timing of a low glycaemic index carbohydrate and 75% reduced insulin dose, prior to running, in type 1 diabetes individuals. After carbohydrate (75 g isomaltulose) and insulin administration, the seven participants rested for 30 min, 60 min, 90 min or 120 min (conditions 30MIN, 60MIN, 90MIN, and 120MIN, respectively) before completing 45 min of running at 70% peak oxygen uptake. Carbohydrate and lipid oxidation rates were monitored during exercise and blood glucose and insulin were measured before and for 3 h after exercise. Data were analysed using repeated-measures analysis of variance. Pre-exercise blood glucose concentrations were lower for 30MIN compared with 120MIN (P < 0.05), but insulin concentrations were similar. Exercising carbohydrate and lipid oxidation rates were lower and greater, respectively, for 30MIN compared with 120MIN (P < 0.05). The drop in blood glucose during exercise was less for 30MIN (3.7 mmol · l(-1), s(x) = 0.4) compared with 120MIN (6.4 mmol · l(-1), s(x) = 0.3) (P = 0.02). For 60 min post-exercise, blood glucose concentrations were higher for 30MIN compared with 120MIN (P < 0.05). There were no cases of hypoglycaemia in the 30MIN condition, one case in the 60MIN condition, two in the 90MIN condition, and five in the 120MIN condition. In conclusion, a low glycaemic index carbohydrate and reduced insulin dose administered 30 min before running improves pre- and post-exercise blood glucose responses in type 1 diabetes.     

Influence of caffeine on perception of effort, metabolism and exercise performance following a high-fat meal

This study examined the effects of caffeine, co-ingested with a high fat meal, on perceptual and metabolic responses during incremental (Experiment 1) and endurance (Experiment 2) exercise performance. Trained participants performed three constant-load cycling tests at approximately 73% of maximal oxygen uptake (VO2max) for 30 min at 20 degrees C (Experiment 1, n = 8) and to the limit of tolerance at 10 degrees C (Experiment 2, n = 10). The 30 min constant-load exercise in Experiment 1 was followed by incremental exercise (15 W . min-1) to fatigue. Four hours before the first test, the participants consumed a 90% carbohydrate meal (control trial); in the remaining two tests, the participants consumed a 90% fat meal with (fat + caffeine trial) and without (fat-only trial) caffeine. Caffeine and placebo were randomly assigned and ingested 1 h before exercise. In both experiments, ratings of perceived leg exertion were significantly lower during the fat + caffeine than fat-only trial (Experiment 1: P < 0.001; Experiment 2: P < 0.01). Ratings of perceived breathlessness were significantly lower in Experiment 1 (P < 0.01) and heart rate higher in Experiment 2 (P < 0.001) on the fat + caffeine than fat-only trial. In the two experiments, oxygen uptake, ventilation, blood [glucose], [lactate] and plasma [glycerol] were significantly higher on the fat + caffeine than fat-only trial. In Experiment 2, plasma [free fatty acids], blood [pyruvate] and the [lactate]:[pyruvate] ratio were significantly higher on the fat + caffeine than fat-only trial. Time to exhaustion during incremental exercise (Experiment 1: control: 4.9, s = 1.8 min; fat-only: 5.0, s = 2.2 min; fat + caffeine: 5.0, s = 2.2 min; P > 0.05) and constant-load exercise (Experiment 2: control: 116 (88 - 145) min; fat-only: 122 (96 - 144) min; fat + caffeine: 127 (107 - 176) min; P > 0.05) was not different between the fat-only and fat + caffeine trials. In conclusion, while a number of metabolic responses were increased during exercise after caffeine ingestion, perception of effort was reduced and this may be attributed to the direct stimulatory effect of caffeine on the central nervous system. However, this caffeine-induced reduction in effort perception did not improve exercise performance.     

An exercise protocol that simulates the activity patterns of elite junior squash

Squash is a popular racket sport that requires intermittent activity with frequent bursts of near maximal-intensity exercise. Consequently, effective physiological and thermoregulatory responses are important contributors to performance during squash match-play. Controlled field-based simulation protocols have been introduced in a growing number of sports, which allow sports scientists to investigate changes in physiology and the efficacy of various interventions in sport-specific contexts. This study aimed to develop an exercise protocol that simulates the physiological requirements of elite squash match-play. Eight elite junior squash players (age 16.2+/-0.8 years, height 1.76+/-0.06 m, body mass 61.3+/-5.9 kg; mean+/-s) completed the following in a randomized order: (1) a squash match against a player of similar standard and (2) a squash-specific incremental exercise protocol (multistage squash test [MST]) followed by the squash simulation protocol (SSP). The multistage squash test was continued for 18.0+/-1.0 min and elicited near maximal post-MST heart rates, blood lactate concentrations and ratings of perceived exertion (198+/-9 beats.min-1, 5.7+/-1.7 mmol.l-1 and 18+/-1, respectively). The SSP was 12.2 min in length compared with mean game length during competitive matches of 10.0+/-1.6 min (P=0.27). Peak heart rates were similar during the SSP and match-play (192+/-11 and 189+/-6 beats.min-1, respectively; P=0.44). Mean exercising heart rates were similar during the SSP (180+/-8 beats.min-1) and match-play (179+/-13 beats.min-1; P=0.73). Peak blood lactate concentrations during the SSP and match-play were 3.5+/-1.5 and 2.4+/-1.2 mmol.l-1 (P=0.07), respectively. Peak ratings of perceived exertion during the SSP and match-play were similar (17+/-2 and 17+/-2, respectively; P=0.64). It was concluded that the SSP closely replicated the demands of squash match-play in elite junior squash players. Furthermore, the SSP provides coaches and scientific support staff with a controlled squash-specific exercise protocol that has potential application in the objective investigation of a range of interventions such as training programmes, nutritional supplements and strategies to maintain core body temperature.     

The physical demands of professional soccer goalkeepers throughout a week-long competitive microcycle and transiently throughout match-play

ABSTRACT

The physical demands of English Premier League soccer goalkeepers were quantified during training and match-play in a two-part study. Goalkeeper-specific micromechanical electrical systems (MEMS) devices, profiled training and match-day activities throughout one competitive week (n=8; part A). Changes in MEMS-derived outputs were also profiled throughout match-play (100 matches; n=8, 18±14 observations per goalkeeper; part B). In part A, goalkeeping-training elicited the most dives (51±11) versus all activities (all p≤0.030) except shooting-training (p=0.069). Small-sided games elicited the fewest (5±3) dives (all p≤0.012). High-speed distance covered in match (103±72 m) was similar to goalkeeping-training (p=0.484), while exceeding shooting-training, small-sided games, pre-match shooting, and pre-match warm-up (all p=0.012). Most changes of direction (34±12) and explosive efforts (70±18) occurred during goalkeeping-training, with values exceeding match (both p=0.012). In part B, between-half reductions in total distance, but increased high-speed changes of direction and explosive efforts, occurred (both p≤0.05). Excluding the number of high jumps, all variables differed from 0-15-min during at least one match epoch, with more dives (1.3±1.4 vs 1.0±1.1) and explosive efforts (2.5±2.4 vs 2.0±1.8) performed between 75-90-min versus 0-15-min (all p<0.05). These data highlight the differing physical demands of various activities performed by professional soccer goalkeepers throughout a competitive week.     

Right–left digit ratio (2D:4D) predicts free testosterone levels associated with a physical challenge

Abstract

There is evidence that the digit ratio (2D:4D) is a negative correlate of prenatal levels of testosterone, but there is no association between 2D:4D and the circulating levels of both total and free testosterone. Sports provide a physical challenge and participants often show increased levels of free testosterone immediately preceding and during competition. We tested this hypothesis of a link between 2D:4D and testosterone under challenge in 79 professional rugby players using the following procedures; (i) 25 players were physically challenged using a repeated sprint agility test, and saliva samples were assayed for testosterone immediately preceding the repeated sprint agility test (time 1) and 5 minutes (time 2) and 20 minutes after completion of the repeated sprint ability (time 3); (ii) 54 players were also tested for salivary testosterone in an unchallenged condition. We found that right-left 2D:4D was significantly and negatively related to testosterone concentrations at times 1, 2 and 3 following the repeated sprint agility test (P < 0.05) and there was no association between the 2D:4D and basal testosterone levels in the unchallenged group. We suggest that low right–left 2D:4D is a predictive marker of free testosterone responsiveness when trained men are physically challenged, and that this association is programmed by the action of prenatal testosterone.