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排序方式: 共有458条查询结果,搜索用时 15 毫秒
1.
Rafaelle Spear Ludovic Boytard Renaud Blervaque Maggy Chwastyniak David Hot Jonathan Vanhoutte Bart Staels Yves Lemoine Nicolas Lamblin Fran?ois-René Pruvot Stephan Haulon Philippe Amouyel Florence Pinet 《International journal of molecular sciences》2015,16(5):11276-11293
Abdominal aortic aneurysm (AAA) is an inflammatory disease associated with marked changes in the cellular composition of the aortic wall. This study aims to identify microRNA (miRNA) expression in aneurysmal inflammatory cells isolated by laser microdissection from human tissue samples. The distribution of inflammatory cells (neutrophils, B and T lymphocytes, mast cells) was evaluated in human AAA biopsies. We observed in half of the samples that adventitial tertiary lymphoid organs (ATLOs) with a thickness from 0.5 to 2 mm were located exclusively in the adventitia. Out of the 850 miRNA that were screened by microarray in isolated ATLOs (n = 2), 164 miRNAs were detected in ATLOs. The three miRNAs (miR-15a-3p, miR-30a-5p and miR-489-3p) with the highest expression levels were chosen and their expression quantified by RT-PCR in isolated ATLOs (n = 4), M1 (n = 2) and M2 macrophages (n = 2) and entire aneurysmal biopsies (n = 3). Except for the miR-30a-5p, a similar modulation was found in ATLOs and the two subtypes of macrophages. The modulated miRNAs were then evaluated in the plasma of AAA patients for their potential as AAA biomarkers. Our data emphasize the potential of miR-15a-3p and miR-30a-5p as biomarkers of AAA but also as triggers of ATLO evolution. Further investigations will be required to evaluate their targets in order to better understand AAA pathophysiology. 相似文献
2.
Paul-Baptiste Rubio François Louf Ludovic Chamoin 《International journal for numerical methods in engineering》2019,120(4):447-472
The motivation of this work is to address real-time sequential inference of parameters with a full Bayesian formulation. First, the proper generalized decomposition (PGD) is used to reduce the computational evaluation of the posterior density in the online phase. Second, Transport Map sampling is used to build a deterministic coupling between a reference measure and the posterior measure. The determination of the transport maps involves the solution of a minimization problem. As the PGD model is quasi-analytical and under a variable separation form, the use of gradient and Hessian information speeds up the minimization algorithm. Eventually, uncertainty quantification on outputs of interest of the model can be easily performed due to the global feature of the PGD solution over all coordinate domains. Numerical examples highlight the performance of the method. 相似文献
3.
Demiguel S. Giraudet L. Joulaud L. Decobert J. Blache F. Coupe V. Jorge F. Pagnod-Rossiaux P. Boucherez E. Achouche M. Devaux F. 《Lightwave Technology, Journal of》2002,20(12):2004-2014
The design, fabrication, and performance of double-stage taper photodiodes (DSTPs) are reported. The objective of this work is to develop devices compatible with 40-Gb/s applications. Such devices require high efficiency, ultrawide band, high optical power handling capability, and compatibility with low-cost module fabrication. The integration of mode size converters improves both the coupling efficiency and the responsivity with a large fiber mode diameter. Responsivity of 0.6 A/W and 0.45 A/W are achieved with a 6-/spl mu/m fiber mode diameter and cleaved fiber, respectively, providing relaxed alignment tolerances (/spl plusmn/1.6 /spl mu/m and /spl plusmn/2 /spl mu/m, respectively), compatible with cost-effective packaging techniques. DSTPs also offer a wide bandwidth greater than 40 GHz and transverse-electric/transverse-magnetic polarization dependence lower than 0.2 dB. Furthermore, a DSTP saturation current as high as 11 mA results in optical power handling greater than +10 dBm and a high output voltage of 0.8 V. These capabilities allow the photodiode to drive the decision circuit without the need of a broad-band electrical amplifier. The DSTP devices presented here demonstrate higher responsivities with large fiber mode diameter and better optical power handling capabilities and are compared with classical side-illuminated photodiodes. 相似文献
4.
The coupling of the changes in bacterial quantitative and metabolic aspects during Microcystis aeruginosa bloom conditions together with several environmental parameters was studied in the hypereutrophic Villerest reservoir, France. Bacterial abundance varied from 5.20 to 21.28 × 106 bacteria-mL?1, while bacterial biomass ranged between 75 and 507 μg C mL?1. These results confirmed the highly eutrophic status of the Villerest reservoir. The relative quantitative importance of attached bacteria increased as Microcystis proliferated. Methyl-3H incorporation and D-(U-14C) glucose uptake varied from 8.99 to 60.57 × 106 cells-mL?1, and 0.016 to 1.587 μg CL?1 h?1, respectively. Correlations between several abiotic and biotic parameters showed that phytoplankton regulated bacterial growth by releasing organic carbon which is directly uptaken by heterotrophic bacteria. In the hypolimnion, the sedimentation of decaying algae represented a substantial substrate for bacterial growth. 相似文献
5.
M. Safar D. Bertrand P. Robert M. F. Devaux C. Genot 《Journal of the American Oil Chemists' Society》1994,71(4):371-377
The combination of attenuated total reflectance (ATR) and mid-infrared spectroscopy (MIRS) with statistical multidimensional
techniques made it possible to extract relevant information from MIR spectra of lipid-rich food products. Wavenumber assignments
for typical functional groups in fatty acids were made for standard fatty acids: Absorption bands around 1745 cm−1, 2853 cm−1, 2954 cm−1, 3005 cm−1, 966 cm−1, 3450 cm−1 and 1640 cm−1 are due to absorption of the carbonyl group, C−H stretch, =CH double bonds of lipids and O−H of lipids, respectively. In
lipid-rich food products, some bands are modified. Water strongly absorbs in the region of 3600–3000 cm−1 and at 1650 cm−1 in butters and margarines, allowing one to rapidly differentiate the foods as function of their water content. Principal
component analysis was used to emphasize the differences between spectra and to rapidly classify 27 commercial samples of
oils, butters and margarines. As the MIR spectra contain information about carbonyl groups and double bonds, the foods were
classified with ATR-MIR, in agreement with their degree of esterification and their degree of unsaturation as determined from
gas-liquid chromatography analysis. However, it was difficult to differentiate the studied food products in terms of their
average chainlength. 相似文献
6.
F. Devaux N. Souli A. Ougazzaden F. Huet M. Carre 《Photonics Technology Letters, IEEE》1996,8(2):218-220
We report on a tandem of electroabsorption modulators integrated with an amplifier by the identical active layer (IAL) approach. A 14 dB fiber-to-fiber is obtained by the use of constant As-P ratio MQW active layer and operation at 10 Gb/s is demonstrated. A record modulator saturation power of 35 mW is also reported. 相似文献
7.
Color quantitation through image processing in dermatology 总被引:1,自引:0,他引:1
Classical color models and their applications to computer vision are reviewed. The performances of color quantitation from digitized images are compared with those derived from a chromameter. The color quantitation obtained from either digitized color slides or directly digitized images is proved to be more efficient than the conventional visual assessment of observers. A methodology is proposed for determining the specific color indices which are needed in dermatology. An application of this methodology is developed for designing a blanching quantitation index in order to replace the visual assessment during McKenzie tests. 相似文献
8.
Polylactide (PLA) has been melt spun to produce multifilament continuous yarns. The thermal characteristics of PLA filaments have been investigated using modulated differential scanning calorimetry (MDSC). With MDSC, it is possible to separate the different thermal events and to analyze them more precisely. The influence of hot drawing on thermal properties of PLA filaments has been studied. Hot drawing promotes an increase of glass transition temperature (Tg) and a decrease of heat capacity. The cold crystallization spreads on a larger range of temperature and the peak occurs at a lower temperature. The initial degrees of cristallinity of PLA filaments have been calculated thanks to the reversing and non reversing curves of MDSC. Tensile properties of PLA filaments are also investigated. 相似文献
9.
The dynamic and partial reconfiguration of FPGAs enables the dynamic placement of applicatives tasks in reconfigurable zones. However, the dynamic management of the tasks impacts the communications since they are not present in the FPGA during all computation time. So, the task manager should ensure the allocation of each new task and their interconnection which is performed by a flexible interconnection network. In this article, various interconnection networks are studied. Each architecture is evaluated with respect to its suitability for the paradigm of the dynamic and partial reconfiguration in FPGA implementations. This study leads us to propose the OCEAN network that supports the communication constraints into the context of dynamic reconfigurations. Thanks to a generic platform allowing in situ characterizations of network performances, fair comparisons of various Networks-On-Chip can be realized. The FPGA and ASICs implementations of the OCEAN network are also discussed. 相似文献
10.
Amphiphilic block copolymers have been investigated for their utilization in emulsion polymerization of butyl methacrylate. Special attention has been paid to the adsorption mechanism of the block copolymers from systematic measurements of equilibrium adsorption isotherms. A series of well-defined water-soluble amphiphilic block copolymers, composed of poly(butyl methacrylate) and poly(sodium methacrylate) blocks, were synthesized by anionic polymerization of butyl methacrylate and tert-butyl methacrylate followed by the thermal deprotection of the tert-butyl ester groups and final hydrolysis. The number density of emulsion polymer particles NP varied as [copolymer]α, α lying between 0.44 and 0.73 according to the hydrophilic content of the copolymers. In contrast with SDS taken as a reference emulsifier, the adsorption of the copolymers was very strong and this provided quite an efficient stabilization of the polymer particles during emulsion polymerization, even at low concentrations (<10−4 mol L−1) and low coverages (<10% of the interfacial area). 相似文献