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排序方式: 共有234条查询结果,搜索用时 31 毫秒
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Stefano J. Mandriota Mirna Tenan Adeline Nicolle Julia D. Jankowska Paolo Ferrari Jean-Christophe Tille Mary-Anne Durin Catherine M. Green Sebastien Tabruyn Daniela Moralli Andr-Pascal Sappino 《International journal of molecular sciences》2020,21(23)
Genomic instability is generally considered as a hallmark of tumorigenesis and a prerequisite condition for malignant transformation. Aluminium salts are suspected environmental carcinogens that transform mammary epithelial cells in vitro through unknown mechanisms. We report here that long-term culture in the presence of aluminium chloride (AlCl3) enables HC11 normal mouse mammary epithelial cells to form tumours and metastases when injected into the syngeneic and immunocompetent BALB/cByJ strain. We demonstrate that AlCl3 rapidly increases chromosomal structural abnormalities in mammary epithelial cells, while we failed to detect direct modulation of specific mRNA pathways. Our observations provide evidence that clastogenic activity—a well-recognized inducer of genomic instability—might account in part for the transforming abilities of aluminium in mammary epithelial cells. 相似文献
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Xin Zhong Luojing Xiang Sebastien Royer Sabine Valange Joel Barrault Hui Zhang 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2011,86(7):970-977
BACKGROUND: A mesoporous alumina supported nanosized Fe2O3 was prepared through an original synthesis procedure and used as a heterogeneous catalyst for the Fenton process degradation of the model azo dye C.I. Acid Orange 7 enhanced by ultrasound irradiation (US/Fe2O3‐Al2O3‐meso/H2O2 system). The effect of various operating conditions was investigated, namely hydrogen peroxide concentration, initial pH, ultrasonic power and catalyst loading. RESULTS: The results indicated that the degradation of C.I. Acid Orange 7 followed a pseudo‐first‐order kinetic model. There exists an optimal hydrogen peroxide concentration, initial pH, ultrasonic power and catalyst loading for decolorization. The aggregate size of the spent catalyst was reduced after dispersion in water by ultrasonic irradiation. A very low level of iron leaching was observed ranging from < 0.1 to 0.23 mg L?1. The intermediate products of C.I. Acid Orange 7 degradation were identified using gas chromatography–mass spectrometry (GC‐MS). CONCLUSION: The optimal conditions for efficient C.I. Acid Orange 7 degradation were pH close to 3, hydrogen peroxide concentration 4 mmol L?1, catalyst loading 0.3 g L?1, and ultrasonic power 80 W. Copyright © 2011 Society of Chemical Industry 相似文献
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Sebastien Narses Faten Sadaka Claire‐Hélène Brachais Jean‐Pierre Couvercelle 《应用聚合物科学杂志》2013,129(5):2891-2904
The coloration of different polymer films (from commodity and packaging films to performance films) by contact with various food coloring substances was evaluated. For this purpose, both solubility parameters as a prediction tool, and immersion experiments for time range between 24 and 1000 h were established. The two predicting tools are the Hoy and Hoftyzer‐Van Krevelen (HVK) methods. For PE and PP, HVK's method is preferred for predicting coloration. Neither of the HVK's and Hoy's methods was able to establish a coloration prediction for PET while both methods could predict the staining of PEEK. The coloration of partially and fully fluorinated polymers is well predicted by the Hoy's method. The behavior of PP/PA and PP/PA/PP multilayer films was also studied. Crystallinity degree of polymers, temperature and concentration of coloring molecules are also important parameters, which are not taken into account in solubility theories. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013 相似文献
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Céline Moulin Alain Glière Daniel Barbier Sebastien Joucla Blaise Yvert Pascal Mailley Régis Guillemaud 《IEEE transactions on bio-medical engineering》2008,55(2):683-692
A transient finite-element model has been developed to simulate an extracellular action potential recording in a tissue slice by a planar microelectrode array. The thin-film approximation of the active neuron membrane allows the simulation within single finite-element software of the intracellular and extracellular potential fields. In comparison with a compartmental neuron model, it is shown that the thin-film approximation-based model is able to properly represent the neuron bioelectrical behavior in terms of transmembrane current and potential. Moreover, the model is able to simulate extracellular action potential recordings with properties similar to those observed in biological experiments. It is demonstrated that an ideal measurement system model can be used to represent the recording microelectrode, provided that the electronic recording system adapts to the electrode-tissue interface impedance. By comparing it with a point source approximated neuron, it is also shown that the neuron three-dimensional volume should be taken into account to simulate the extracellular action potential recording. Finally, the influence of the electrode size on the signal amplitude is evaluated. This parameter, together with the microelectrode noise, should be taken into account in order to optimize future microelectrode designs in terms of the signal-to-noise ratio. 相似文献
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Stephan Schöttl Richard Rusby Henri Godfrin Matthias Meschke Valérie Goudon Sebastien Triqueneaux Andrea Peruzzi Martin J. de Groot Reyer Jochemsen Wim Bosch Yves Hermier Laurent Pitre Céline Rives Bernd Fellmuth Jost Engert 《Journal of Low Temperature Physics》2005,138(3-4):941-946
No Heading Recently, a superconductive reference device, SRD1000, with ten reference materials has been developed to enable simplified in situ calibration of interpolating thermometers. We report on the evaluation of SRD1000 prototypes at various laboratories. The devices were built and tested by HDL and KOL, calibrated at NMi-VSL and then distributed to other partners where they were re-calibrated against the local realisations of the PLTS-2000 or laboratory scales. As a result, we obtained data on the superconductive transition temperatures, widths and shapes for four different devices. Reproducibility, sharpness of the transitions, supercooling and sensitivity to magnetic fields are evaluated. This leads to estimates of the uncertainty in determination of the transition midpoint and temperature.PACS numbers: 07.20.Dt, 07.20.Mc, 74.62.–c, 74.70.Ad 相似文献