固真方对老年大鼠肝脏c－myc、c－fos、p53表达的影响

为了进一步探讨固真方延理衰老的分子机理，本文用斑点杂交技术研究了固真方对大鼠肝组织与增殖密切相关的基因──原癌基因（ｃ－ｍｙｃ、ｃ－ｆｏｓ）和抗癌基因ｐ５３表达的影响。结果显示：ａ．ｃ－ｍｙｃ、ｃ－ｆｏｓ的表达老年对照组较青年对照组明显降低（Ｐ＜０．０１）．而老年用药组较老年对照组明显增高（Ｐ＜０．０１）。ｂ．ｐ５３的表达老年对照组与青年对照组及老年用药组与老年对照组之间的变化无统计学意义。     

Association of Haemophilus influenzae infection with environmental and climatic factors in Suzhou,China北大核心CSCD

Objective To investigate the epidemiological characteristics of respiratory Haemophilus influenzae (HI) infection in children in Suzhou, China and its association with climatic factors and air pollutants. Methods The data on air pollutants and climatic factors in Suzhou from January 2016 to December 2019 were collected. Respiratory secretions were collected from 7 940 children with acute respiratory infection who were hospitalized during this period, and bacterial culture results were analyzed for the detection of HI. A stepwise regression analysis was used to investigate the association of HI detection rate with air pollutants (PM2.5, PM10, NO2, SO2, CO, and O3) and climatic factors (monthly mean temperature, monthly mean humidity, monthly total rainfall, monthly total sunshine duration, and monthly mean wind speed). Results In 2016-2019, the 4-year overall detection rate of HI was 9.26% (735/7 940) among the children in Suzhou. The children aged <1 year and 1-<3 years had a significantly higher HI detection rate than those aged ≥3 years (P <0.01). The detection rate of HI in spring was significantly higher than that in the other three seasons, and the detection rate of HI in autumn was significantly lower than that in the other three seasons (P<0.001). The multiple linear regression analysis showed that PM10 and monthly mean wind speed were independent risk factors for the detection rate of HI: the detection rate of HI was increased by 0.86% for every 10 µg/m3 increase in the concentration of PM10 and was increased by 5.64% for every 1 m/s increase in monthly mean wind speed. Air pollutants and climatic factors had a lag effect on the detection rate of HI. Conclusions HI is an important pathogen for acute respiratory infection in children in Suzhou and is prevalent in spring. PM10 and monthly mean wind speed are independent risk factors for the detection rate of HI. © 2022 Xiangya Hospital of CSU. All rights reserved.     

在中国人中检出HLA-B15的一个新分解物SH7

使用第 9届国际组织相容性专题讨论会血清,在中国人中发现 B15的一个新反应格局,我们暂称为 SH7。在18个家庭中,有4个家庭带有 SH7并在孩子中表现出分离。来自中国人群的血清 460以及第 9届会议血清 9w179、9w180、9w277、9w278 含有 Bw62和 SH7。SH7似乎是介于Bw35和B15之间的中间抗原,它能够与Bw62、Bw35以及Bw53区别,并在它们存在时被检出。结果证明了B15是一个远比现在分解为Bw62和Bw63更为复杂的复合体。     

口服曲马多用于甲状腺手术超前镇痛对麻醉效果的影响

目的观察口服曲马多缓释片用于甲状腺次全切除手术超前镇痛对麻醉效果的影响。方法采用随机、双盲、空白对照的研究方法，择期行甲状腺次全切除手术患者160例，随机分为实验组（A组）和对照组（B组洛80例。实验组术前2h口服曲马多缓释片100mg和胃复安10mg；对照组则在相同时间点仅口服胃复安10mg。观察两组病人术中镇痛效果、病人神志、血压和心率变化。结果术毕视觉模拟评分实验组镇痛效果和对照组并没有显著性差异（P〉0．05），而术后恶心发生率实验组明显高于对照组（P〈0．05）。结论口服曲马多缓释片用于甲状腺次全切除手术进行超前镇痛，并不能有效增强术中的麻醉效果，而且具有一定的副作用。     

补肾益精等不同治法对老年大鼠肝还原型谷胱甘肽、过氧化脂质的影响

补肾益精的固真方在临床应用证实具有良好的延缓衰老作用,动物实验提示能提高防御酶——超氧化物歧化酶(SOD),降低 LPO,本文试图进一步观察对机体的防御物质 CTSH 的影响,并且比较补肾益精等不同治法对防御物质及自由基生成的影响。1 材料与方法1.1 实验动物分组与给药方法:本实验选用雄性SD 大鼠106只。由本院实验动物中心提供,随机分为8个组:(1)老年对照组:28月龄16只,正常饮水及饲料;(2)青年对照组:4月龄20只,正常饮水及饲     

与HLA-A2纯合子细胞反应的一组血清

在6名经产妇献血员血清中,发现一个起共同反应的HLA抗体,被称为抗SH1。该抗体与大约19％的表现型为A2的细胞反应,通过血清学和遗传学分析表明,抗SH1实际检出的是HLA-A2纯合子细胞。     

培训农村药学技术人员近五百名

近日，北京市药品监督管理局平谷分局制定了“出查书制度”和“服务质量追踪制度”。这两项制度规范了监管各个环节，改革了监管随意性的管理模式。     

卡孕栓及宫术宁胶棒用于人工流产术的临床观察

目的探讨卡孕栓及宫术宁胶棒在早期妊娠人工流产术中的扩张宫颈效果及镇痛作用。方法将240例人工流产者随机分为A组（120例）和B组（120例）。结果 A组术前1 h阴道后穹窿放置卡孕栓1 mg。B组术前宫颈管应用宫术宁胶棒,观察两组人工流产术中的宫颈松弛程度、镇痛效果。A组和B组宫颈松弛总有效率分别为87.50%和76.67%,镇痛总有效率分别为77.50%和65.00%,两组间差异有统计学意义（P〈0.05）。卡孕栓用于早期妊娠人工流产宫颈扩张效果和镇痛作用均高于宫术宁胶棒,且临床使用安全方便,值得推广。