基于SPEI的渭河流域干旱时空变化特征分析

以标准化降水蒸散指数（SPEI）作为评估指标，基于渭河流域28个气象站点1961—2017年实测降水量和气温数据，采用Mann-Kendall（M-K）趋势检验、经验正交函数以及小波变换等方法分析渭河流域干旱时空变化特征，并研究渭河流域干旱与6种大尺度气候因子之间的相关关系，进一步探讨主要气候因子对流域干旱时空分布特征的潜在影响。研究表明：渭河流域在1961—2017年间整体呈现出变旱的趋势。通过经验正交函数分解，渭河流域干旱分布场主要有3种典型模态类型，分别为全局型、西北—东南反向分布型以及东—西反向分布型；同时，大尺度气候因子南方涛动指数SOI与流域干旱分布场具有更好的相关关系，对该区域内干旱变化有较强的影响。     

缓冲溶液法制备高效的铁基类芬顿催化剂

负载型金属催化剂在水处理中起着重要的作用，浸渍法是制备负载型催化剂的重要方法。为了克服传统浸渍方法的缺点，本文通过使用甘氨酸/盐酸作为缓冲溶液，严格控制pH，获得高分散的活性组分并以此方法制备了铁基类芬顿催化剂。对苯酚催化降解的实验表明，使用缓冲溶液法制备的催化剂比未使用的样品可以更高效地去除苯酚，1h内对苯酚的降解可达89.3%。此外，通过调节浸渍温度、浸渍时间和缓冲溶液的pH等参数来精确控制活性组分的量和催化活性。更重要的是，此催化剂制备方法可以用于其他负载型金属催化剂的制备，比如过硫酸盐催化剂，并取得了良好的催化效果。     

印度河流域气温、降水、蒸发及干旱变化特征

基于印度河流域及周围54个地面气象站气温、降水资料，结合CRU气温和GPCC降水全球格点化陆面再分析资料，通过插值构建了一套0.5°×0.5°分辨率1980—2016年逐月格点数据集。采用Thornthwaite方法计算了潜在蒸散发，基于标准化降水蒸散指数（SPEI），探讨了印度河流域气候变化及干旱演变特征。结果表明：（1）1980—2016年，印度河流域年平均气温以0.30℃·（10 a）^-1的速率呈显著上升趋势，21世纪初增温幅度最大；干季（11月~次年4月）升温速率较快，达0.36℃·（10 a）^-1，湿季（5~10月）增速0.25℃·（10 a）^-1。年降水量呈现少雨—多雨—少雨—多雨年代际振荡。伴随着持续升温，年和各季的潜在蒸发量增加显著。干季干旱频率较多，但湿季干旱强度高，各季干旱频率与降水呈现较一致的年代际波动；干旱的影响面积在干季呈现微弱地增加趋势，湿季却略有减少趋势。（2）空间上，除西北局部，流域其他区域的年和季平均气温、潜在蒸发量增加趋势显著，均达到95%置信水平。其中南部平原和东北山区升温幅度较高，南部平原区潜在蒸发量增加也较大。新德里到喀布尔的东南至西北带状区域的年和湿季降水量，以及喀布尔周围地区的干季降水量呈显著增加趋势。东南平原区和东北局部山区的干季，以及东北和西南局部山区的湿季呈现显著的干旱化态势，需要加强防灾减灾的意识并采取相应措施，以规避干旱增多带来的不利影响。     

Simulation and projection of climate change using CMIP6 Muti-models in the Belt and Road Region

Climate condition over a region is mostly determined by the changes in precipitation, temperature and evaporation as the key climate variables. The countries belong to the Belt and Road region are subjected to face strong changes in future climate. In this paper, we used five global climate models from the latest Sixth Phase of Coupled Model Intercomparison Project (CMIP6) to evaluate future climate changes under seven combined scenarios of the Shared Socioeconomic Pathways and the Representative Concentration Pathways (SSP1-1.9, SSP1-2.6, SSP2-4.5, SSP3-7.0, SSP4-3.4, SSP4-6.0 and SSP5-8.5) across the Belt and Road region. This study focuses on undertaking a climate change assessment in terms of future changes in precipitation, air temperature and actual evaporation for the three distinct periods as near-term period (2021-2040), mid-term period (2041-2060) and long-term period (2081-2100). To discern spatial structure, K?ppen-Geiger Climate Classification method has been used in this study. In relative terms, the results indicate an evidence of increasing tendency in all the studied variables, where significant changes are anticipated mostly in the long-term period. In addition to, though it is projected to increase under all the SSP-RCP scenarios, greater increases will be happened under higher emission scenarios (SSP5-8.5 and SSP3-7.0). For temperature, robust increases in annual mean temperature is found to be 5.2 °C under SSP3-7.0, and highest 7.0 °C under SSP5-8.5 scenario relative to present day. The northern part especially Cold and Polar region will be even more warmer (+6.1 °C) in the long-term (2081-2100) period under SSP5-8.5. Similarly, at the end of the twenty-first century, annual mean precipitation is inclined to increase largely with a rate of 2.1% and 2.8% per decade under SSP3-7.0 and SSP5-8.5 respectively. Spatial distribution demonstrates that the largest precipitation increases are to be pronounced in the Polar and Arid regions. Precipitation is projected to increase with response to increasing warming most of the regions. Finally, the actual evaporation is projected to increase significantly with rate of 20.3% under SSP3-7.0 and greatest 27.0% for SSP5-8.5 by the end of the century. It is important to note that the changes in evaporation respond to global mean temperature rise consistently in terms of similar spatial pattern for all the scenarios where stronger increase found in the Cold and Polar regions. The increase in precipitation is overruled by enhanced evaporation over the region. However, this study reveals that the CMIP6 models can simulate temperature better than precipitation over the Belt and Road region. Findings of this study could be the reliable basis for initiating policies against further climate induced impacts in the regional scale.     

Pressurized IntraPeritoneal Aerosol Chemotherapy with one minute of electrostatic precipitation (ePIPAC) is feasible,but the histological tumor response in peritoneal metastasis is insufficient

IntroductionElectrostatic precipitation Pressurized IntraPeritoneal Aerosol Chemotherapy (ePIPAC) has shown superior penetration depth and tissue uptake compared to standard PIPAC. We investigated the feasibility and objective tumor response to ePIPAC with 1 min of precipitation in patients with peritoneal metastasis (PM).Materials and methodsPatients with PM from various abdominal cancers were included in an amendment to the ongoing prospective PIPAC-OPC2 trial. Colorectal and appendiceal PM were treated with oxaliplatin, patients with PM from other primaries were treated with a combination of cisplatin and doxorubicin. Three ePIPAC procedures were planned in each patient including repeated peritoneal biopsies for response evaluation. After emission to the peritoneal cavity, the aerosolized chemotherapeutics were precipitated for 1 min followed by immediate exsufflation and abdominal closure. Histological regression from the first to the third ePIPAC was evaluated according to the Peritoneal Regression Grading Score (PRGS) and compared to data from the PIPAC-OPC1 trial. Complications and toxicities were recorded according to Dindo-Clavien and CTCAE.ResultsSixty-five ePIPAC procedures were performed in 33 patients (median 2, range 1–6). Ten patients were eligible for response evaluation based on biopsies from the first and third ePIPAC procedure. Four patients had disease progression, four patients had regressive disease, and two patients had stable disease according to PRGS. No life threatening adverse reactions and no mortality was observed following ePIPAC.ConclusionOne minute ePIPAC was feasible and safe, but the histological tumor response was insufficient compared to standard PIPAC directed therapy with 30 min passive diffusion time.     

Preparation of molecularly imprinted fluorescence sensor based on carbon quantum dots via precipitation polymerization for fluorescence detection of tetracycline

A facile and effective method was proposed to prepare the molecularly imprinted fluorescence sensor with carbon quantum dots, which were modified vinyl groups by acrylic acid on the surface. The obtained fluorescence composite material was investigated by transmission electron microscope and Fourier transform infrared spectra. After the experimental conditions were optimized, a linear range of 1.0–60 μmol L⁻¹ was obtained and the detection limit was 0.17 μmol L⁻¹. The novel fluorescence sensor can be successfully used to detect tetracycline in real samples. This study provides a convenient strategy for selective recognition and rapid detection of tetracycline in the complex environment.     

氮对镀锡钢板的强化作用

通过物理化学相分析研究了3种不同氮含量镀锡板中固溶氮、化合氮的含量,结合相关理论计算了镀锡板中氮的固溶强化和析出强化对强度的贡献。结果表明:随着总氮含量从0.0021%提高到0.0103%,钢中化合氮含量下降10.1%,但是AlN析出相中的氮的含量上升10.7%。氮在提高镀锡板强度方面发挥重要作用,钢中总氮含量提高0.0082%,其对屈服强度的贡献值提升约30 MPa。     

载As2O3 pH敏感钙砷复合物脂质体的制备及体外评价

目的 制备pH敏感释药的As₂O₃脂质体，并进行体外评价。方法 采用薄膜分散法制备含钙离子脂质体，然后用离子沉淀法孵育制备钙砷复合物脂质体（CaAs-LP）。测定CaAs-LP的粒径、Zeta电位及多分散系数（PDI）；透射电子显微镜观察脂质体的形态；电感耦合等离子体发射光谱仪测定纳米药物的载药量与包封率；透析袋法考察其体外释药特性。噻唑蓝（MTT）法考察未载药脂质体及CaAs-LP对人源性乳腺癌MCF-7细胞、人源性脑胶质瘤U87细胞和人源性肝癌HepG2细胞的毒性；共聚焦显微镜考察U87细胞对CaAs-LP的摄取效率。结果 制备的CaAs-LP呈规整类球型，粒径约为（117.16±1.94）nm，包封率和载药量分别为（74.31±2.11）%、（8.31±0.13）%。体外释放研究表明，CaAs-LP具有明显的缓释以及pH响应释药特征。未载药的脂质体在MCF-7、U87、HepG2和L02细胞中的生物相容性良好；CaAs-LP抑制肿瘤细胞生长的作用较原药有所上升，半数抑制浓度（IC₅₀）值分别为11.91、4.90、19.41、27.59 μmol/L。细胞摄取研究表明肝癌细胞对脂质体具有良好的摄取。结论 CaAs-LP具备显著的缓释以及pH响应释药的特性，在肿瘤治疗方面具有较好的应用前景。     

酸性废水中As(Ⅲ)、Cu(Ⅱ)与铁粉的反应行为

在Fe-As(Ⅲ)-Cu(Ⅱ)-H₂O体系中, 研究了酸性废水中As(Ⅲ)、Cu(Ⅱ)与金属铁粉的反应行为, 考察了反应过程中As在气、液、固三相中的分配比。结果表明, As(Ⅲ)和Cu(Ⅱ)离子被Fe还原为单质As和Cu后, As、Cu进一步结合成Cu₅As₂等金属间化合物, 从而促进As(Ⅲ)沉淀反应的发生, 且无AsH3生成。在反应时间40min、铁粉过量系数1.2、溶液初始pH=0.0、温度40 ℃、Cu/As摩尔比1.0条件下, As在气、液、固三相中的分配比分别为0、20.7%和79.3%, 沉砷率为79.3%。